Nanotechnology‐Enabled Closed Loop Insulin Delivery Device: In Vitro and In Vivo Evaluation of Glucose‐Regulated Insulin Release for Diabetes Control

Recently, a new multifunctional, bio‐inorganic nanocomposite membrane with the ability to self‐regulate the release of insulin in response to blood glucose (BG) levels was reported. Herein, the application of this material as part of a small, implantable, closed‐loop insulin delivery device designed to continuously monitor BG concentrations and regulate insulin release is proposed. The insulin delivery device consists of a nanocomposite glucose‐responsive plug covalently bound to an insulin reservoir made of surface‐modified silicone. The plug is prepared with crosslinked bovine serum albumin (BSA) and enzymes (glucose oxidase (GOx) and catalase (CAT)), pH‐responsive hydrogel nanoparticles, and multifunctional MnO₂ nanoparticles. The plug functions both as a glucose sensor and controlled delivery unit to release higher rates of insulin from the reservoir in response to hyperglycemic BG levels and basal insulin rates at normal BG concentration. The surfaces of the device are modified by silanization followed by PEGylation to ensure its safety and biocompatibility and the stability of encased insulin. Our results show that insulin release can be modulated in vitro in response to glucose concentrations. In vivo experiments show that the glycemia of diabetic rats can be controlled with implantation of the prototype device. The glucose‐responsiveness of the device is also demonstrated by rapid drop in BG level after challenging diabetic rats with bolus injection of glucose solution. In addition, it is demonstrated that surface PEGylation of the device is necessary for reducing the immune response of the host to the implanted foreign object and maintaining insulin stability and bioactivity. With this molecular architecture and the bio‐inorganic nanocomposite plug, the device has the ability to maintain normal BG levels in diabetic rats.     

互联网数据业务安全防护措施

随着互联网数据业务的快速发展,行业需求潜力巨大,互联网数据业务市场对于中国移动的未来发展具有重要影响,但数据业务营销过程中越来越多的安全威胁被引入,依托信息技术平台运行的业务信息、客户信息等面临的风险日益加大,提升数据业务系统的安全风险防护能力势在必行.     

基于EM78P419N单片机的消毒烘干机的设计

为了改善传统烘干机烘手时间长、易交叉感染、可靠性低等问题,进行了消毒干手机的设计。该设计利用红外技术检测信号,再将光信号转换成电信号送入EM78P419N单片机,通过单片机的处理后,启动电磁阀和滴水泵进行消毒。定时完成后,启动加热器和风扇进行烘干。整个过程完全自动控制,避免了交叉感染,手伸即喷,手离即停。同时,研制出的样品具有成本低、体积小、可靠性高、干手时间短等优点,在各类人员聚集或流动的场所应用广泛。     

TS20XS系列DSP程序优化设计方法及应用

TS20XS系列DSP是一款高性能数字信号处理器＾［7］。由于在实际工程中对算法的实时性要求越来越高,所以要合理使用DSP的硬件资源和编程语言,进而减少指令的执行周期,提高算法的运行效率。．本文分别从TS20XS系列DSP两组寄存器组的使用、IF—DO—ELsE指令的使用、系数存储单元的合理分配、指令间延时的减少、双整型逻辑运算单元的综合运用这几方面探讨了DSP程序的优化设计方法,并结合实例给出优化设计结果。     

基于多源信息和改进证据理论的空战攻击决策

针对证据理论不能有效地处理带冲突证据信息的缺点,结合已有的证据理论改进算法研究了一种新的多源信息融合策略并应用于多机协同空战决策。根据不同的前提条件采用不同的融合规则,并在融合过程中引入可靠性度量,以反映具体证据的信任度。同时采用闭世界和开世界的观点,区别两种不同部分冲突信息的分配并考虑融合的顺序,提高冲突证据的融合效率。仿真结果表明所研究的融合策略能够得到较好的空战攻击决策结果。     

蓄电池循环寿命测试系统设计分析

随着科技的发展及工业现代化,环境污染是当前国际性问题。蓄电池是人类研制出的性能优异的储能设备,还有IT产品的大量应用。市场上对蓄电的需求量越来越大。而每个厂家的产品质量不同,需要对电池的循环寿命进行检测。本课题设计了基于TMS320F2812的DSP芯片为控制中心,由高性能的A/D转换器TLC2543和D/A转换器MAX538等构成的蓄电池循环寿命检测系统。同时易于计算机相连,形成一个自动的检测网络。而且按相关的标准进行放电,研究发现取得了很好的效果。     

四站无解及模糊问题的增站处理方法

针对无源时差定位系统中存在系统误差和偶然误差而产生的定位模糊和无解的问题,在研究以伪逆法作为求解方法的四站定位基础上,依据不同布站形式其定位结果不同的事实,采用增加一个测量站的方法进行求解定位。对5个接收站接收到的目标信息时间差,采用主站循环的方式分别进行解算,对解算结果进行相关性分析、模糊值剔除,并对小于5个的正确解算值进行融合处理,最终得到目标的位置信息。通过对真实数据加上随机误差进行仿真试验验证,结果表明,该方法能够解决四站无解及定位模糊问题,同时提高了对目标辐射源的定位精度,并十分适用于工程实现。     

Hybrid Linear Closed‐Form Solution in Wireless Localization

In wireless localization, several linear closed‐form solution (LCS) methods have been investigated as a direct result of the drawbacks that plague the existing iterative methods, such as the local minimum problem and heavy computational burden. Among the known LCS methods, both the direct solution method and the difference of squared range measurements method are considered in this paper. These LCS methods do not have any of the aforementioned problems that occur in the existing iterative methods. However, each LCS method does have its own individual error property. In this paper, a hybrid LCS method is presented to reduce these errors. The hybrid LCS method integrates the two aforementioned LCS methods by using two check points that give important information on the probability of occurrence of each LCS's individual error. The results of several Monte Carlo simulations show that the proposed method has a good performance. The solutions provided by the proposed method are accurate and reliable. The solutions do not have serious errors such as those that occur in the conventional standalone LCS and iterative methods.     

基于寿命周期成本管理的输变电设备状态检修方法分析

文章对输变电寿命周期成本管理内涵进行分析,并基于寿命周期成本管理对输变电设备状态检修方法进行研究,最后结合实例进一步了解和掌握检修方法,旨在为输变电状态检修提供更多支持.     

黄河下游断流初步分析及缓解对策

进入９０年代以来，黄河下游河道连续发生断流，且有初始时间提前、时段延长、河段向上延伸的趋势。黄河断流给下游及沿黄地区带来不利影响，对黄河下游防洪和生态环境也造成威胁。要避免和缓解断流发生，必须大力开展节约用水，实现国务院批准的分水方案以法管水；在枯水年、枯水季节对水资源实行统一调度；积极兴建干流调蓄工程，提高黄河水资源利用的整体效益。