Bone Marrow-Mesenchymal Stromal Cell Secretome as Conditioned Medium Relieves Experimental Skeletal Muscle Damage Induced by Ex Vivo Eccentric Contraction

Bone marrow-mesenchymal stem/stromal cells (MSCs) may offer promise for skeletal muscle repair/regeneration. Growing evidence suggests that the mechanisms underpinning the beneficial effects of such cells in muscle tissue reside in their ability to secrete bioactive molecules (secretome) with multiple actions. Hence, we examined the effects of MSC secretome as conditioned medium (MSC-CM) on ex vivo murine extensor digitorum longus muscle injured by forced eccentric contraction (EC). By combining morphological (light and confocal laser scanning microscopies) and electrophysiological analyses we demonstrated the capability of MSC-CM to attenuate EC-induced tissue structural damages and sarcolemnic functional properties’ modifications. MSC-CM was effective in protecting myofibers from apoptosis, as suggested by a reduced expression of pro-apoptotic markers, cytochrome c and activated caspase-3, along with an increase in the expression of pro-survival AKT factor. Notably, MSC-CM also reduced the EC-induced tissue redistribution and extension of telocytes/CD34⁺ stromal cells, distinctive cells proposed to play a “nursing” role for the muscle resident myogenic satellite cells (SCs), regarded as the main players of regeneration. Moreover, it affected SC functionality likely contributing to replenishment of the SC reservoir. This study provides the necessary groundwork for further investigation of the effects of MSC secretome in the setting of skeletal muscle injury and regenerative medicine.     

无伸缩缝混凝土防渗衬砌渠道跳仓浇筑施工技术

现浇混凝土防渗渠道普遍采用设置伸缩缝的方法防止混凝土产生裂缝,而伸缩缝的止水易因老化和长草等遭受破坏,导致渠道渗漏。针对上述弊端提出了无伸缩缝混凝土防渗衬砌渠道的隔板跳仓浇筑施工技术。经过在多个大中型灌区节水项目中推广应用,总结出该施工技术的操作步骤和技术要点,包括基面处理措施,浇筑方法,操作要点,浇筑,振捣、抹面等的质量要求及适用范围。多年的运行实践表明,该技术可明显节约投资、缩短工期、延长使用寿命、有效改善防渗效果,且施工简便、工程质量易于保证等。     

关于狭义相对论中时空问题的讨论

狭义相对论明确指出同时性、时间和空间的测量是相对的,与物体的运动状态或与参考系的选取密切相关,并以此建立了相对论时空观.基于狭义相对论中时空概念的关联分析,讨论了解决时空问题的思路和方法,指出了＂同时性的相对性＂是理解和认识相对论时空观的基础,有利于解决大学物理教学的重难点问题.     

PET/PTT复合纤维的卷曲性能与形态结构

以POY-DT和FDY工艺获得的不同规格、本色和有色PET/PTT复合纤维为研究对象,考察了纤维规格、工艺路线和色母粒对PET/PTT复合纤维的卷缩性能的影响,表征了复合纤维的轴向形态结构与断面结构,研究了纤维力学性能.结果表明,PET/PTT复合纤维的卷曲性能随着线密度的增加而升高,在130 dtex附近达到峰值;本...     

利用多点互相关值均值的实时声源定位算法

基于可控响应功率的麦克风阵列声源定位算法在噪声和混响环境中具有较好的鲁棒性,但是利用网格搜索方法寻找可控响应功率的最大值计算复杂度很高。故提出一种新的实时声源定位算法,使用网格中多互相关值均值代替单点的可控响应功率值作为代价函数,通过多级区域收缩方法实现了代价函数最大值的空间搜索,并给出一种不显著增加计算量的互相关值求和范围的计算方式。由于利用了网格中更多的空间采样信息,因此可以使用更大尺度的搜索网格,从而降低了整个搜索过程的计算复杂度。     

Influence of seismic input on response of Baihetan arch dam

The dynamic responses of the arch dam including dam-foundation-storage capacity of water system, using two different earthquake input models, i.e. viscous-spring artificial boundary （AB） condition and massless foundation （MF）, were studied and analyzed for the 269 m high Baihetan arch dam under construction in China. By using different input models, the stress and opening of contraction joints （OCJs） of arch dam under strong shock were taken into consideration. The results show that the earthquake input models have slight influence on the responses including earthquake stresses and openings of contraction joints in different extents.     

Al3Ti/ZL101原位复合材料的铸造性能研究

测试了Al3Ti/ZL101原位复合材料的流动性、线收缩率、热裂倾向及铸造应力，分析了影响铸造性能的各种因素。结果表明：Al3Ti/ZL101原位复合材料的热裂抗力较基体材料大、线收缩率较基体材料小、铸造应力略大于基体材料；在780℃以下，Al3Ti/ZL101原位复合材料的流动性优于基体材料。对Al3Ti/ZL101原位复合材料采用同基体材料相同的铸造工艺即能满足生产要求。     

新型水平连铸智能控制系统的研究

介绍一种小棒径铸铁型材牵引控制系统，系统采用直流调速器、PLC和触摸屏技术，使控制系统能够实现正向拉拔、反向推入及快速制动等拉坯工艺，成功地拉出φ30mm以下的铸铁型材，填补该行业的国内空白。     

Effect of copper addition on the thermal contraction of indium melt clusters

The structure of In-1%Cu and In-5%Cu (mass fraction) alloy melts were studied at different temperatures above liquidus by using a high-temperature X-ray diffractometer and were compared with that of pure In melt. Experimental results show that with the addition of 1% Cu or 5% Cu, the thermal contraction phenomenon of atom clusters occurs in melts with the temperature increasing like pure In melt. With the addition of 1% Cu, the thermal contraction of atom clusters increases and the contraction is not homogeneous in the whole measurement temperature range. The sudden change and noticeable contraction can be found in the range of 280-390℃. The temperature range of the sudden change is lower than that of pure In melt. With the addition of 5% Cu, the thermal contraction of atom clusters decreases and the contraction is not consistent in the whole measurement temperature range. The anomalous change can be measured at about 600 ℃. At the same superheating temperature, the nearest interatomic distance r1 of     

小型球铁件的收缩特点及其补缩工艺

根据国内外有关研究结果，阐述了球墨铸铁件冷却凝固过程中的体积变化规律，建立了球墨铸铁的收缩和膨胀模型，用以分析球墨铸铁小件的缩孔缩松形成机理。以轮毂铸件为例提出了防止缩孔缩松缺陷的工艺措施。