The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype–phenotype maps

Biological information is stored in DNA, RNA and protein sequences, which can be understood as genotypes that are translated into phenotypes. The properties of genotype–phenotype (GP) maps have been studied in great detail for RNA secondary structure. These include a highly biased distribution of genotypes per phenotype, negative correlation of genotypic robustness and evolvability, positive correlation of phenotypic robustness and evolvability, shape-space covering, and a roughly logarithmic scaling of phenotypic robustness with phenotypic frequency. More recently similar properties have been discovered in other GP maps, suggesting that they may be fundamental to biological GP maps, in general, rather than specific to the RNA secondary structure map. Here we propose that the above properties arise from the fundamental organization of biological information into ‘constrained'' and ‘unconstrained'' sequences, in the broadest possible sense. As ‘constrained'' we describe sequences that affect the phenotype more immediately, and are therefore more sensitive to mutations, such as, e.g. protein-coding DNA or the stems in RNA secondary structure. ‘Unconstrained'' sequences, on the other hand, can mutate more freely without affecting the phenotype, such as, e.g. intronic or intergenic DNA or the loops in RNA secondary structure. To test our hypothesis we consider a highly simplified GP map that has genotypes with ‘coding'' and ‘non-coding'' parts. We term this the Fibonacci GP map, as it is equivalent to the Fibonacci code in information theory. Despite its simplicity the Fibonacci GP map exhibits all the above properties of much more complex and biologically realistic GP maps. These properties are therefore likely to be fundamental to many biological GP maps.     

FeOOH–CoS composite catalyst with high catalytic performances for oxygen evolution reaction at high current density

Water electrolysis is an efficient approach for high-purity hydrogen production. However, the anodic sluggish oxygen evolution reaction (OER) always needs high overpotential and thus brings about superfluous electricity cost of water electrolysis. Therefore, exploiting highly efficient OER electrocatalysts with small overpotential especially at high current density will undoubtedly boost the development of industrial water electrolysis. Herein, we used a simple hydrothermal method to prepare a novel FeOOH–CoS nanocomposite on nickel foam (NF). The as-prepared FeOOH–CoS/NF catalyst displays an excellent OER performance with extremely low overpotentials of 306 and 329 mV at 500 and 1000 mA cm⁻² in 1.0 M KOH, respectively. In addition, the FeOOH–CoS/NF catalyst can maintain excellent catalytic stability for more than 50 h, and the OER catalytic activity shows almost no attenuation no matter after 1000 repeated CV cycles or 50 h of stability test. The high catalytic activity and stability have exceeded most non-noble metal electrocatalysts reported in literature, which makes the FeOOH–CoS/NF composite catalyst have promising applications in the industrial water electrolysis.     

基于进化算法的常减压装置模拟

提出了基于优选优生进化算法（Select—best and prepotency evolution algorithm，SPEA）的常减压装置模拟方法。以各塔的温度分布为目标，基于生产过程和分析数据，采用SPEA确定各塔板Murphree效率，从而精确描述各塔板平衡偏离程度。在实际应用中，获得具有良好精度的常减压装置模型。系统分析了SPEA算法的关键参数——优选领域大小与计算复杂性及寻优性能之间的关系，结果显示其取值为群体规模的10％最为合适。     

H.264/AVC技术进展及其务实发展策略思考

结合NGN及3G演进的固定、移动视频业务实际需求状况，论述H．264／AVC的重要技术进展及其务实发展策略。     

Antenna-array pattern nulling using a differential evolution algorithm

A new method based on the differential evolution (DE) algorithm is proposed for antenna-array pattern synthesis with prescribed nulls. The array excitation amplitudes are the only controlling parameters, and the objectives are to synthesize array patterns with nulls imposed on directions of interferences while keeping the sidelobe levels (SLLs) below prescribed levels. Many factors such as the excitation dynamic range ratio, null depth level, null width, and SLLs are taken into account in the synthesis. Simulation results of several typical problems are compared with published results to illustrate the effectiveness of the proposed method. © 2003 Wiley Periodicals, Inc. Int J RF and Microwave CAE 14: 57–63, 2004.     

水量还原方法及合理性检查

文中详细地阐述了取河水、井水、水库水、跨流城引(排)水等不同情况进行还原的具体方法步骤。并对水量还原成果提出合理性检查措施。     

中扬子及邻区层序地层与原型盆地演化

中扬子及邻区原型盆地可划分为 9个大层序,其中,1～6大层序由中、古生代海相地层组成;第 7大层序为早、中侏罗纪的陆相沉积;第 8大层序为晚侏罗世的前渊沉积;第 9层序为晚白垩世至第三纪的伸展盆地。震旦纪,中部地区为台地相环境,向南为浅海陆棚环境,向北以陆表海为主;寒武纪至早奥陶世为典型的大陆边缘盆地;中、晚奥陶世至志留纪为裂谷盆地发展阶段;泥盆纪至石炭纪该区发生广泛海侵,与华南海域和太平洋海域多处相连;二叠纪至早、中三叠世为原型盆地的重要转型时期,随着分隔秦岭微板块与扬子板块的勉略古洋盆向东打开,扬子北缘由前期的区域性隆起转变为向北加深的大陆边缘盆地;晚三叠世经历了两次幕式旋回,巴东组沉积时期盆地沉降缓慢,九里岗组沉积时期则较快;早、中侏罗世原型盆地早幕 (早侏罗世)沉积缓慢,晚幕 (中侏罗世)快速沉降,以水下沉积作用为主;晚侏罗世可划分为两大构造演化阶段,早期构造活动相对平静,晚期强烈;晚白垩世至老第三纪,盆地范围缩小,以湖泊、河流体系为主。由此,中扬子及邻区在地质历史时期经历了 4种不同性质的原型盆地,具有幕式充填特征。     

韩江三角洲海岸变迁遥感调查研究

利用1:10万TM影像，对广东东部韩江三角洲地区的海岸变迁及河道演变进行了调查研究。划分了不同时期的海岸界线和古河道遗迹，提出韩江三角洲的形成是河流动力和海洋动力共同作用的结果，对研究历史海平面变化及环境演变具重要意义。     

准噶尔盆地侏罗系储集层的基本特征及其主控因素分析

从描述储集层基本特征、分析储集层性质的主控因素、建立储集层成因模式和评价、预测储集层性质这 4个层次 ,研究准噶尔盆地重点勘探目标区的侏罗系储集层。系统总结侏罗系储集层岩石学特征 ,认为成岩压实作用强弱是控制储集层性质的关键因素 ;指出相对优质储集层均为剩余原生粒间孔隙型储集层 ,溶蚀作用对渗透率贡献小 ;非煤系储集层的孔隙保存条件明显比煤系储集层好 ,这是三工河组、头屯河组和吐谷鲁群的物性普遍优于八道湾组和西山窑组的原因。在确定储集层性质的控制因素和控制机理基础上 ,建立了煤系和非煤系两大类储集层的成因 演化模型。在上述研究的基础上 ,分地区、分层位评价了储集层 ,并预测了不同渗透率储集层的深度界线及相对优质储集层的平面分布。图 6参 10     

构造作用对油气生成和运聚的影响

有机质从埋藏开始，就处于极其复杂的地球物理化学场中，环境提的能量，一是热量，二是机械能，机械能，主要是通过机械力作用传递给系统的，另外还以机械波的形式赋予系统一定的机械能。当发生断褶构造运动时，机械力对油气运移的影响尤为突出，它经能量的迁移转化，促成了包括机械力降解和地应力驱动等一系列的连锁反应，制造了一次次高效的成油（生运）事件，本文以突变论为着眼点，按照改造控制建造的思路，大胆提出构造运动制造生排烃事件，成就含油气系统的假说。