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排序方式: 共有4413条查询结果,搜索用时 15 毫秒
71.
提出和实现了一种面向HDL描述基于路径覆盖的模拟矢量自动生成方法,该方法在约束生成时只考虑控制语句的条件表达式,可有效避免生成冗余约束;利用扩展的决策图模型解决了中间信号到初始输入的传播问题和信号依赖关系问题,以及处理各种HDL描述风格的问题;采用约束逻辑编程方法解决了由位、位向量和整型变量组成的约束系统的统一处理问题,实验结果表明该方法能加快模拟矢量生成速度,提高路径覆盖率.生成的模拟矢量也能用于低层次设计验证和故障模拟,加快了设计进度,将该方法的原型系统用于一个32位微处理器核RTL级验证,发现了RTL级设计描述中的错误. 相似文献
72.
采用矢量细分的异步电动机直接转矩控制系统 总被引:13,自引:0,他引:13
介绍了一种采用矢量细分和SVPWM调制的直接转矩控制方法,实现对电机转矩的控制。将该控制方法应用到异步电动机调速系统,通过系统仿真实验验证,该控制方法的输出转矩脉动小、电流谐波低、开关频率固定,调速系统有着良好的动态性能和调速精度。 相似文献
73.
统计不相关最佳鉴别矢量集的本质研究 总被引:6,自引:0,他引:6
对统计不相关最佳鉴别矢量集的本质进行研究,在基于总体散布矩阵特征分解的基础上,构造了一种白化变换,使得变换后的样本空间中的总体散布矩阵为单位矩阵,这样使得传统的最佳鉴别矢量集算法得到的均是具有统计不相关的最佳鉴别矢量集,从而揭示了统计不相关最佳鉴别变换的本质——白化变换加普通的线性鉴别变换。该方法的最大优点在于所获得的最优鉴别矢量同时具有正交性和统计不相关性。该方法对代数特征抽取具有普遍适用性。用ORL人脸数据库的数值实验,验证了该方法的有效性。 相似文献
74.
火炬树叶的抗氧化性及其与Vc协同作用的研究 总被引:3,自引:0,他引:3
赵爱云 《青岛大学学报(工程技术版)》2004,19(2):30-32
为研究火炬树叶的抗氧化性及其与Vc、柠檬酸的协同作用,本文以猪油为底物,采用高温诱导使其发生脂质过氧化反应,测定体系的过氧化值,结果表明:火炬树叶甲醇提取物可有效延缓猪油脂质过氧化反应,适量加入Vc可提高其抗氧化性。 相似文献
75.
In this study, the PEGylated nanostructured lipid carriers (PEG-NLC) were constructed for the intravenous delivery of 17-allylamino-17-demethoxygeldanamycin (17AAG). 17AAG-PEG-NLC was successfully prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature using a mixture of glycerol monostearate and PEG2000-stearate as solid lipids, and medium-chain triglyceride as the liquid lipid. The results revealed that the morphology of the NLC was spheroidal. The particle size, zeta potential and entrapment efficiency for 17AAG-PEG-NLC were observed as 189.4?nm, ?20.2 mV and 83.42%, respectively. X-ray diffraction analysis revealed that 17AAG existed as amorphous structures in the nanoparticles. In the in vitro release study, the 17AAG from 17AAG-PEG-NLC exhibited a biphasic release pattern with burst release initially and sustained release afterwards. In addition, 17AAG-PEG-NLC showed a significantly higher in vitro antitumor efficacy and longer retention time in vivo than 17AAG solution. These results indicated that 17AAG-PEG-NLC may offer a promising alternative to the current 17AAG formulations for the treatment of solid tumors. 相似文献
76.
Lipolysis and lipid oxidation caused by Staphylococcus xylosus 135 and Saccharomyces cerevisiae 31 isolated from Suan yu,a traditional Chinese low‐salt fermented fish 下载免费PDF全文
Pei Gao Weixin Wang Wenshui Xia Yanshun Xu Qixing Jiang 《International Journal of Food Science & Technology》2016,51(2):419-426
The aim of this study was to investigate the lipolysis and lipid oxidation of Staphylococcus xylosus 135 and Saccharomyces cerevisiae 31 in Suan yu. Suan yu were made inoculated with and without two strains at different stages, and model systems of emulsions were also established. Lipolysis and lipid oxidation were evaluated by determining the changes in free fatty acid (FFA) content and composition, conjugated diene (CD) value and thiobarbituric acid reactive substances (TBARS) value. The total FFA of the sample without cultures increased from 476.61 mg/100 g fat to 1413.89 mg/100 g fat after 5 weeks fermentation, while those of samples with cultures declined to 258.98 and 452.89 mg/100 g fat, respectively. On the other hand, CD and TBARS values of samples with inoculation markedly increased. In the model system, higher FFA, CD and TBARS values for the samples added with CFE were observed. This study showed that Staphylococcus xylosus 135 and Saccharomyces cerevisiae 31 made a significant contribution to lipolysis and lipid oxidation during the processing of Suan yu. 相似文献
77.
The objective of the present investigation was to improve the skin deposition and retention of metronidazole (MTZ) in rosacea therapy by incorporating it into nanostructured lipid carriers (NLCs). The main challenge in this endeavor was the partial hydrophilicity of MTZ, which mandated careful selection of excipients, including solid and liquid lipids, surfactants, and their ratios in combination. NLCs were produced by the phase inversion temperature method and finally converted into a gel for topical application. The prepared nanoparticles were evaluated for their particle size, zeta potential, entrapment efficiency, solid-state characteristics, surface morphology, in vitro drug release, and permeation through excised skin. The gel was additionally characterized for its pH, drug content, viscosity, and spreadability. The prepared nanoparticles were spherical in shape and of size less than 300?nm. Incorporation of judiciously chosen excipients made possible a relatively high entrapment efficiency of almost 40%. The drug release was found to be biphasic, with an initial burst release followed by sustained release up to 8?hours. In comparison to the plain drug gel, which had a tissue deposition of 11.23%, the NLC gel showed a much superior and desirable deposition of 26.41%. The lipophilic nature of the carrier, its size, and property of occlusion enabled greater amounts of drug to enter and be retained in the skin, simultaneously minimizing permeation through the skin, i.e. systemic exposure. The results of the study suggest that NLCs of anti-rosacea drugs have the potential to be used in the therapy of rosacea. 相似文献
78.
《Drug development and industrial pharmacy》2013,39(4):439-448
Background: As a promising anticancer drug, severe side-effects of current clinical formulations for paclitaxel have restricted its use, developing a better technical-economical formulation for paclitaxel delivery is needed. Method: In this study, the compound of folate-poly(ethylene glycol) (PEG)-phosphatidylethanolamine was synthesized and characterized with Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The solid-liquid lipid nanoparticle (SLLN) for paclitaxel modified with folate and poly(ethylene glycol) (folate-PEG-SLLN) was prepared and characterized. Morphology of folate-PEG-SLLN was examined by transmission electron microscopy. The particle size and zeta potential were performed by Zetapals. Encapsulation efficiency was analyzed by HPLC. The in vitro drug release of paclitaxel was investigated via membrane dialysis. The in vivo pharmacokinetics was measured with male Sprague-Dawley rats. Treatment efficiency was investigated with the mouse with sarcoma180 ascites tumor. Results: Paclitaxel loaded on the newly designed binary SLLN showed a longer and sustained in vitro releasing property. More importantly, S180 tumor-bearing mice treated with paclitaxel-loaded SLLN exhibited higher tumor inhibition rate, comparing with animals administered with paclitaxel injection alone (45.3% and 37.3%, respectively). Conclusion: The newly developed paclitaxel delivery system may have improved in vivo antitumor activity. The results demonstrated a great interest to use folate-mediated SLLN as a prospective drug delivery system for paclitaxel. 相似文献
79.
Jun-Hee Jang Han-Gon Choi Jung Hoon Sung 《Drug development and industrial pharmacy》2013,39(3):363-368
To develop 2-(allylthio)pyrazine (2-AP)-loaded lipid emulsion for parenteral administration, various lipid emulsions were prepared with soybean oil, lecithin, and other carriers using homogenization method, and their physical stabilities were investigated by measuring their droplet sizes. The pharmacokinetics and tissue distribution of 2-AP in lipid emulsion after intravenous administration to rats were evaluated compared with 2-AP in solution. 2-AP was lipophilic, sparingly water-soluble, and unstable in aqueous medium. The 2-AP-loaded lipid emulsion composed of 1% of 2-AP, 4% of soybean oil, 4% of lecithin, and 91% of water was physically and chemically stable for at least 8 weeks. It gave significantly faster clearance of 2-AP and higher affinity to the organs, especially the liver, compared with the 2-AP in solution, suggesting that it could selectively deliver 2-AP to the liver. Thus, the lipid emulsion with soybean oil and lecithin could be used as a potential dosage form with the liver-targeting property and enhanced stability of sparingly water-soluble 2-AP. 相似文献
80.