Early Lipid Raft-Related Changes: Interplay between Unilateral Denervation and Hindlimb Suspension

Muscle disuse and denervation leads to muscle atrophy, but underlying mechanisms can be different. Previously, we have found ceramide (Cer) accumulation and lipid raft disruption after acute hindlimb suspension (HS), a model of muscle disuse. Herein, using biochemical and fluorescent approaches the influence of unilateral denervation itself and in combination with short-term HS on membrane-related parameters of rat soleus muscle was studied. Denervation increased immunoexpression of sphingomyelinase and Cer in plasmalemmal regions, but decreased Cer content in the raft fraction and enhanced lipid raft integrity. Preliminary denervation suppressed (1) HS-induced Cer accumulation in plasmalemmal regions, shown for both nonraft and raft-fractions; (2) HS-mediated decrease in lipid raft integrity. Similar to denervation, inhibition of the sciatic nerve afferents with capsaicin itself increased Cer plasmalemmal immunoexpression, but attenuated the membrane-related effects of HS. Finally, both denervation and capsaicin treatment increased immunoexpression of proapoptotic protein Bax and inhibited HS-driven increase in antiapoptotic protein Bcl-2. Thus, denervation can increase lipid raft formation and attenuate HS-induced alterations probably due to decrease of Cer levels in the raft fraction. The effects of denervation could be at least partially caused by the loss of afferentation. The study points to the importance of motor and afferent inputs in control of Cer distribution and thereby stability of lipid rafts in the junctional and extrajunctional membranes of the muscle.     

The Complex and Critical Role of Glycine 12 (G12) in Beta-Connexins of Human Skin

Glycine is an amino acid with unique properties because its side chain is composed of a single hydrogen atom. It confers conformational flexibility to proteins and conserved glycines are often indicative of protein domains involving tight turns or bends. All six beta-type connexins expressed in human epidermis (Cx26, Cx30, Cx30.3, Cx31, Cx31.1 and Cx32) contain a glycine at position 12 (G12). G12 is located about halfway through the cytoplasmic amino terminus and substitutions alter connexin function in a variety of ways, in some cases altering protein interactions and leading to cell death. There is also evidence that alteration of G12 changes the structure of the amino terminus in connexin- and amino acid- specific ways. This review integrates structural, functional and physiological information about the role of G12 in connexins, focusing on beta-connexins expressed in human epidermis. The importance of G12 substitutions in these beta-connexins is revealed in two hereditary skin disorders, keratitis ichthyosis and erythrokeratodermia variabilis, both of which result from missense mutations affecting G12.     

基于信息间隙决策理论的储能电站鲁棒优化配置

储能电站在转移电力需求、平抑可再生能源和负荷波动等方面发挥着重要的作用,储能电站容量优化配置是其在规划建设过程中所需要解决的关键问题。文中提出一种基于信息间隙决策理论（IGDT）的双层鲁棒优化配置模型,为解决系统在运行过程中的不确定参数带来的负面影响,模型下层搭建以经济性为目标的储能电站日前鲁棒优化运行模型;模型上层引入IGDT将经济性和鲁棒性相结合,在一定的预期目标下最大化系统能够承受的波动性,使用Benders分解法求解模型,并以IEEE 33节点配电网系统验证方案有效性,结果表明所提方案可以兼顾经济性与鲁棒性,为储能规划提供参考依据。     

Development of ultra-narrow gap welding with constrained arc by flux band

0 IntroductionThe merits of narrow gap welding (NGW) such ashigh productivity and quantity, minimal distortion, highcost-effectiveness, and all position capability are wellknown. The narrower the gap, the more significant the a-bove merits. Moreover, while an ultra-narrowgap welding(UNGW) process with less than 5 mm gap width is used,its some advantages are very useful for preventing thestress corrosion crack in austenitic steel piping, and forwelding some update steels. For example, in aus…     

水压环形缝隙泄漏量的试验研究

在水压系统环形缝隙泄漏试验基础上，对圆柱形配合状态下的缝隙泄漏量进行了理论和试验对比研究，分析了两者的变化规律。得出的结果可以为水压元件的设计提供试验依据。     

接触器特征参数测试仪

本文详细介绍了微机型接触器特征参数测试仪工作原理，软硬件及调试、运行和故障处理。     

3300mm轧机辊缝位置控制系统的研制

介绍3300mm中厚板可逆热轧机辊缝调整机构的组成,设计了3300mm轧机辊缝位置控制系统控制方案,给出了该方案中压下电机调速系统的设计过程,最终依据设计方案研制了辊缝控制系统,并在实际生产中运行使用。现场运行结果表明,用有准备切换逻辑无环流控制系统控制压下电机的辊缝位置,性能稳定,定位迅速,控制精度达到±0.3mm。宝钛集团使用该设备生产的钛及钛合金中厚板、镍板、锆及锆合金板等质量达到国际同类产品的先进水平。     

电火花加工与加工中心的集成

提出了一种新的复合型机床——在加工中心上进行电火花加工的机床，研究了电火花加工与加工中心集成所存在的主要技术要求，提出并设计了伺服控制系统，介绍了伺服控制系统的原理。为验证这个想法的合理性，在普通的铣床上进行了模拟集成试验并进行了分析与评价。     

一种检测电火花加工间隙状态的柔性方法

介绍了一种在数控电火花加工脉冲电源中实现间隙状态检测的柔性方法，具有阈值设置柔性、状态识别准确的特点，巧妙地用一个稳压二极管的钳位作用提高了间隙状态识别的精度，非常适合需经常改变加工参数的加工实验使用。     

用直接纺丝法制芳纶短纤维

研究了直接纺丝制取芳纶短纤维的新方法。讨论了纤维长度、直径及力学性能与纺丝条件的关系。发现影响纤维长度的主要因素是空气层高度和喷丝速度,影响纤维直径的主要因素为喷口直径及喷丝速度。此外,还用PPTA短纤维制成了均匀的PPTA"浆粕"纤维。