用PIXE方法研究骨折家兔骨骼微量元素的变化

用质子激发X荧光分析法测定48只家兔在挠骨骨折愈合过程中骨骼中多种微量元素含量的变化。结果表明，Fe和Sr分别呈鼓凸形和下凹形规律性变化，故Fe和Sr含量的变化可作为骨折愈合过程的指示剂。在骨折愈合过程中发现骨骼和血液中元素钙的相对含量保持不变，故无法为西医用补充钙来治疗骨折的疗法提供依据，但我们的研究结果却表明中医补充微量元素治疗骨折的疗法是有道理的。     

架空乘人装置用隔爆兼本安型控制箱的研制

针对采用继电器控制方式控制架空乘人装置存在维护困难、工作效率低、安全性能差等问题,提出了一种基于PLC控制的架空乘人装置用控制箱的研制方案,介绍了该控制箱的硬件、软件设计及功能特点。该控制箱采用PLC作为控制核心、MT6070I系列触摸屏作为人机界面,实现了架空乘人装置及时停车、急停闭锁、状态及时显示、保护等功能。实际应用表明,该控制箱运行稳定,实现了全自动无人值守运行,提高了架空乘人装置的安全性和可靠性。     

基于嵌入式技术的带式输送机控制系统

针对基于PLC的带式输送机控制系统存在体积大、PLC程序更改不方便、成本高等问题,提出了一种基于嵌入式技术的带式输送机控制系统的设计方案;详细介绍了该系统中嵌入式本质安全控制机、控制驱动器、远程I/O模块的硬件及软件设计。实际应用表明,该系统解决了基于PLC的带式输送机控制系统存在的问题,具有较好的稳定性、灵活性和友好性。     

防爆变频器在煤矿应用中的关键技术

分析了防爆变频器在煤矿井下使用过程中存在的电压等级、散热、电磁兼容性、逆变器转换效率等问题,详细介绍了解决这些问题的方法,即通过采用隔爆兼本质安全型技术和热管散热技术解决变频器的防爆和散热问题,使防爆变频器具有性能高、功能强、噪音低等特点;通过改变变频器的电路拓扑结构、改进控制策略等技术手段解决变频器的电磁兼容性和能耗问题,使防爆变频器满足煤矿生产的现代化要求。     

矿用隔爆兼本安型计算机信号隔离器设计

针对煤矿井下电气设备要求本质安全的特点,设计了一种矿用隔爆兼本安型计算机信号隔离器,主要介绍了该隔离器的硬件电路设计。该隔离器主要用于矿井中本质安全型计算机主机与外部输入输出设备的连接,能够实时地传送键盘输入的数据,具有良好的信号隔离功能和抗干扰性能。     

矿用隔爆兼本质安全型不间断直流稳压电源的设计

基于本质安全型电源的原理及特点,提出了一种矿用隔爆兼本质安全型不间断直流稳压电源的设计方案,详细介绍了该电源主要电路的设计。该电源采用LM317可调稳压芯片实现稳压功能,具有使用方便、电路简单、变换效率高、成本低等优点。测试结果表明,该电源达到了本安标准,满足了安全型电气设备的需求。     

煤矿井下采掘设备隔爆兼本安型电气控制箱的本安设计

针对煤矿井下采掘设备防爆兼本安型电气控制箱内本安电路与非本安电路并存、非本安电路的能量可能会窜入本安电路而影响本安电路防爆及本安性能的问题,从结构设计和电气隔离两方面介绍了煤矿井下采掘设备隔爆兼本安型电气控制箱的本安设计方法,给出了电气间隙、爬电距离、绝缘及耐压、接线端子、本安布线、电源变压器、本安隔离栅印制板等结构布置方法以及RS485通信隔离电路、模拟量隔离电路、压频变换电路、电阻信号隔离电路、开关量隔离电路、继电器隔离电路等电气隔离措施。应用表明,采用该方法设计的煤矿井下采掘设备隔爆兼本安型电气控制箱安全可靠,维护简便,能够满足煤矿井下的防爆要求。     

Photovoltaic effect and carrier transport mechanisms in Hg1-Mnxtdiodes

Hg_1-xMn_xTe semiconducting semimagnetic alloy has been examined in the context of its possible applications in infrared detectors. For analysis of detector properties the intrinsic carrier concentration has been calculated as a function of temperature and crystal composition. The starting material was In-doped Hg_1-xMn_xTe grown by the modified Bridgman method. The as-grown crystals with manganese content of 12-19% were p-type with carrier concentration and mobility of 100 cm²/ Vs at 77 K. An-type layer was formed on the surface by the annealing process in saturated Hg-vapour at 270-320° for 2 hrs. Capacitance-voltage curves have C^-3 dependence on applied voltage indicating that the junction is linearly graded. From standard electrical measurements and spectral characteristics the main detector parameters were determined and compared to those of Hg_1-xCd_xTe devices. The influence of material properties on detector parameters was analyzed. In order to estimate the carrier transport mechanisms, differential resistivities and current-voltage curves were measured over a wide range of temperaturesi.e. 25 to 300 K. From the temperature dependence of the R₀A product, it was established that at high temperatures (150-300 K) the carrier transport is dominated by a recombination-generation mechanism. In low temperature region the excess current at forward bias is probably attributed to carrier tunneling via energy states distributed randomly within the forbidden gap. At reverse bias the leakage surface or volume currents dominate in the carrier transport.     

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells. Primary MSCs can be obtained from diverse sources, including bone marrow, adipose tissue, and umbilical cord blood. Recently, MSCs have been recognized as therapeutic agents for skin regeneration and rejuvenation. The skin can be damaged by wounds, caused by cutting or breaking of the tissue, and burns. Moreover, skin aging is a process that occurs naturally but can be worsened by environmental pollution, exposure to ultraviolet radiation, alcohol consumption, tobacco use, and undernourishment. MSCs have healing capacities that can be applied in damaged and aged skin. In skin regeneration, MSCs increase cell proliferation and neovascularization, and decrease inflammation in skin injury lesions. In skin rejuvenation, MSCs lead to production of collagen and elastic fibers, inhibition of metalloproteinase activation, and promote protection from ultraviolet radiation-induced senescence. In this review, we focus on how MSCs and MSC-derived molecules improve diseased and aged skin. Additionally, we emphasize that induced pluripotent stem cell (iPSC)-derived MSCs are potentially advanced MSCs, which are suitable for cell therapy.     

Dehydropeptide Supramolecular Hydrogels and Nanostructures as Potential Peptidomimetic Biomedical Materials

Supramolecular peptide hydrogels are gaining increased attention, owing to their potential in a variety of biomedical applications. Their physical properties are similar to those of the extracellular matrix (ECM), which is key to their applications in the cell culture of specialized cells, tissue engineering, skin regeneration, and wound healing. The structure of these hydrogels usually consists of a di- or tripeptide capped on the N-terminus with a hydrophobic aromatic group, such as Fmoc or naphthalene. Although these peptide conjugates can offer advantages over other types of gelators such as cross-linked polymers, they usually possess the limitation of being particularly sensitive to proteolysis by endogenous proteases. One of the strategies reported that can overcome this barrier is to use a peptidomimetic strategy, in which natural amino acids are switched for non-proteinogenic analogues, such as D-amino acids, β-amino acids, or dehydroamino acids. Such peptides usually possess much greater resistance to enzymatic hydrolysis. Peptides containing dehydroamino acids, i.e., dehydropeptides, are particularly interesting, as the presence of the double bond also introduces a conformational restraint to the peptide backbone, resulting in (often predictable) changes to the secondary structure of the peptide. This review focuses on peptide hydrogels and related nanostructures, where α,β-didehydro-α-amino acids have been successfully incorporated into the structure of peptide hydrogelators, and the resulting properties are discussed in terms of their potential biomedical applications. Where appropriate, their properties are compared with those of the corresponding peptide hydrogelator composed of canonical amino acids. In a wider context, we consider the presence of dehydroamino acids in natural compounds and medicinally important compounds as well as their limitations, and we consider some of the synthetic strategies for obtaining dehydropeptides. Finally, we consider the future direction for this research area.