Red-Blood-Cell-Membrane-Coated Metal-Drug Nanoparticles for Enhanced Chemotherapy

To overcome high toxicity, low bioavailability and poor water solubility of chemotherapeutics, a variety of drug carriers have been designed. However, most carriers are severely limited by low drug loading capacity and adverse side effects. Here, a new type of metal-drug nanoparticles (MDNs) was designed and synthesized. The MDNs self-assembled with Fe(III) ions and drug molecules through coordination, resulting in nanoparticles with high drug loading. To assist systemic delivery and prolong circulation time, the obtained MDNs were camouflaged with red blood cell (RBCs) membranes (RBCs@Fe-DOX MDNs) to improve their stability and dispersity. The RBCs@Fe-DOX MDNs presented pH-responsive release functionalities, resulting in drug release accelerated in acidic tumor microenvironments. The outstanding in vitro and in vivo antitumor therapeutic outcome was realized by RBCs@Fe-DOX MDNs. This study provides an innovative design guideline for chemotherapy and demonstrates the great capacity of nanomaterials in anticancer treatments.     

CENTUM-CS1000在离子膜制碱工艺中的应用

介绍了DCS在离子膜制碱工艺中的应用及常用控制方案的实现和运行效果。     

离子膜使用过程中起泡的原因及危害

分析并列举了离子交换膜在使用过程中鼓泡的原因，阳极液质量浓度；pH值；阴极液质量浓度；电流密度；开停车及盐水质量等因素都可以造成膜鼓泡，形成针孔。提出了相应的预防措施。     

我国烧碱生产技术概况

介绍了我国氯碱行业近几年来的发展情况：分析了我国烧碱生产的工艺技术现状。指出了为缩短与世界先进国家的差距需要加快开发关键设备和高性能的离子膜，加强管理。     

磷钨杂多酸催化乙醇和乙酸酯化反应的研究

以多孔钛片为支撑体,制备了磷钨杂多化合物薄膜化催化剂。在膜催化器上,考察了薄膜化催化剂对乙醇和乙酸合成乙酸乙酯的催化性能。结果表明,薄膜化催化剂显著提高了催化活性;当n(乙醇)∶n(乙酸)=1.5∶1,原料流量2.55mL/h;在反应温度为110℃时,乙酸乙酯产率可达97%,且薄膜催化剂的处理很方便,不污染环境。     

甲酸甲酯合成与转化的催化技术

本文评述了甲酸甲酯(MF)合成与转化的催化技术,展示了从MF出发发展C_1化学的可能途径,在MF的合成方面详细地分析了从甲醇出发的羰化法、脱氢法和氧化法催化技术,简介了我们的有关研究工作。     

SEPARATION AND ENRICHMENT OF WEAK ORGANIC ACIDS OR BASES BY IMMOBILIZED LIQUID MEMBRANES

A new and effective liquid membrane process to achieve both separation and enrichment simultaneously of weak organic acids or bases was developed. The process utilizes effectively the difference in the apparent partition coefficient of the constituent species between the aqueous and organic phases, and uses the change of the apparent partition coefficients with the hydrogen ion concentration of the aqueous phase. For such a fundamental model apparatus as a diaphragm diffusion cell being operated batch wise, the effects of pK value of solutes, permeability of solutes through the membrane, volume ratio of liquids in two aqueous phases, and pH value of aqueous phase on enrichment factor and selectivity for the solute to be concentrated were discussed analytically. Separation and enrichment were demonstrated using aqueous mixed solutions of fumaric acid and L-malic acid. The results were in good agreement with the theoretical predictions.     

连续式双膜分离塔的数学模型

本文建立了适用于连续式双膜分离塔的数学模型。用实验数据验证了数学模型的可行性和合理性。将本模型与已发表的模型进行了比较,结果表明本模型具有形式简单、计算方便和适用范围更宽广等优点。