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971.
    
Smooth muscle cells (SMCs) migration and matrix metalloproteinase‐2 (MMP‐2) activation are main roles in atherosclerosis. Pterostilbene (trans‐3, 5‐dimethoxy‐4‐hydroxystilbene) is known to have various pharmacologic effects such as anti‐inflammatory and anticarcinogenic properties. The present study aimed to investigate the anti‐atheroscleroic property of pterostilbene in the rat smooth muscle cell (SMC) A7r9 cell lines and the underlying mechanisms. In this study, pterostilbene treatment significantly inhibited migration/invasion capacities of in A7r9 cell. Pterostilbene was also found to significantly decreased MMP‐2 activity and expression by gelatin zymography and western blot assay in SMC. In the MAPK signaling pathway, western blot assay also indicated that pterostilbene up‐regulated the phosphorylation of extracellular‐signal‐regulated kinase (Erk)1/2. Moreover, inhibition of Erk1/2 by specific inhibitors significantly abolished the pterostilbene‐decreased expression of MMP‐2 and migration/invasion capacities. These findings suggest that pterostilbene inhibited SMC migration and that MMP‐2 activation could be mediated via Erk1/2 phosphorylation. It is further possible that pterostilbene could play a novel role in the treatment of atherosclerosis.  相似文献   
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974.
    
Culturing beef from bovine satellite cells can be done and the urgent need for alternative beef production requires full‐scale research into this interesting possibility. © 2013 Society of Chemical Industry  相似文献   
975.
    
This research explores the cryoprotective potential of gelatin hydrolysate by determining weight loss and physicochemical changes in the muscle protein of freeze–thawed shrimp. Shrimp treated with gelatin hydrolysate exhibited significantly higher and lower weight gain (9.20%) than those treated with distilled water (0.93%) and mixed phosphates (16.99%), respectively. Gelatin hydrolysate could lower the increasing rate of thawing and cooking loss and freezable water content in freeze–thawed shrimp (P < 0.05) and comparable to those of mixed phosphates treated shrimp (P > 0.05). As the shrimp were subjected to freeze–thawing, gelatin hydrolysate slowed the decline of protein solubility and Ca2+-ATPase activity and mitigated the rise of surface hydrophobicity and disulfide bond content. It also delayed the shear force increase. These findings suggest that gelatin hydrolysate could be an effective alternative to traditional cryoprotectants, retarding weight loss and protein denaturation to preserve shrimp quality during freezing and frozen storage.  相似文献   
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977.
    
The article presents the problems of determination of the static characteristics of the pneumatic muscle actuator for an artificial hand. The procedure of experimental investigation of the constant load characteristics (the so called isotonic characteristics) of the muscle is described. A new mathematical model for the isotonic characteristics is developed based on the geometry of the muscle. The new model provides a very good agreement between the calculation and experimental results.  相似文献   
978.
《Ergonomics》2012,55(8):1424-1432
Lumbar muscle fatigue is a potential risk factor for the development of low back pain. In this study, we investigated the influence of lumbar extensor muscle fatigue on lumbar–pelvic coordination patterns during weightlifting. Each of the 15 male subjects performed five repetitions of weightlifting tasks both before and after a lumbar extensor muscle fatiguing protocol. Lumbar muscle electromyography was collected to assess fatigue. Trunk kinematics was recorded to calculate lumbar–pelvic continuous relative phase (CRP) and CRP variability. Results showed that fatigue significantly reduced the average lumbar–pelvic CRP value (from 0.33 to 0.29 rad) during weightlifting. The average CRP variability reduced from 0.17 to 0.15 rad, yet this change ws statistically not significant. Further analyses also discovered elevated spinal loading during weightlifting after the development of lumbar extensor muscle fatigue. Our results suggest that frequently experienced lumbar extensor muscle fatigue should be avoided in an occupational environment.

Practitioner Summary: Lumbar extensor muscle fatigue generates more in-phase lumbar–pelvic coordination patterns and elevated spinal loading during lifting. Such increase in spinal loading may indicate higher risk of back injury. Our results suggest that frequently experienced lumbar muscle fatigue should be avoided to reduce the risk of LBP.  相似文献   
979.
    
The aim of this study was to evaluate the effects of muscle fatigue of triceps surae and quadriceps muscles in stepping down in ongoing gait. We expected that the subjects would compensate for muscle fatigue to prevent potential loss of balance in stepping down. A total of 10 young participants walked over a walkway at a self-selected velocity to step down a height difference of 10-cm halfway. Five trials were performed before and after a muscle fatigue protocol. Participants performed two fatigue protocols: one for ankle muscle fatigue and another for knee muscle fatigue. Kinematics of and ground reaction forces on the leading leg were recorded. Fatigue did not cause a change in the frequency of heel or toe landing. Our results indicate that in stepping down fatigue effects are compensated by redistributing work to unfatigued muscle groups and by gait changes aimed at enhancing balance control, which was however only partially successful.  相似文献   
980.
    
This paper describes the estimation of the optimal measurement position by discriminant analysis based on Wilks’ lambda for myoelectric hand control. In previous studies, for motion discrimination, the myoelectric signals were measured at the same positions. However, the optimal measurement positions of the myoelectric signals for motion discrimination differ depending on the remaining muscles of amputees. Therefore, the purpose of this study is to estimate the optimal and fewer measurement positions for precise motion discrimination of a human forearm. This study proposes a method for estimating the optimal measurement positions by discriminant analysis based on Wilks’ lambda, using the myoelectric signals measured at multiple positions. The results of some experiments on the myoelectric hand simulator show the effectiveness of the proposed optimal measurement position estimation method. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(8): 32–40, 2013; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/ecj.11465  相似文献   
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