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11.
This paper is prepared in honour of Professor E.T. Brown for his outstanding contributions to rock mechanics and geotechnical engineering and also for his personal influence on the first author's research career in geomechanics and geotechnical engineering. As a result, we have picked a topic that reflects two key research areas in which Professor E.T. Brown has made seminal contributions over a long and distinguished career. These two areas are concerned with the application of the critical state concept to modelling geomaterials and the analysis of underground excavation or tunnelling in geomaterials.Partially due to Professor Brown's influence, the first author has also been conducting research in these two areas over many years. In particular, this paper aims to describe briefly the development of a unified critical state model for geomaterials together with an application to cavity contraction problems and tunnelling in soils. 相似文献
12.
电网的安全水平主要取决于其使用产品的质量是否过关。如果产品的质量较好,则能建造出优质的电网,电网的安全水平便会随之提高。因此,应加强对产品质量的监督管理,从而提高电网的安全水平。我们可建立质量监督管理系统,及时抽检出质量不过关的产品,从而消除电网运行过程中潜在的安全隐患。 相似文献
13.
14.
《Planning》2015,(1)
目的 探讨气管上段腺样囊性癌的临床病理特征及诊断和鉴别诊断要点。方法 收集2000年1月至2014年2月在北京协和医院确诊的4例气管上段腺样囊性癌病例,通过光镜、免疫组织化学及组织化学染色分析其临床病理特征、免疫组织化学特点、诊断及鉴别诊断要点。结果 4例气管上段腺样囊性癌患者中,男1例,女3例,平均年龄47岁(38~57岁);既往均无腺样囊性癌病史,1例患者既往有结节性甲状腺肿手术史。镜下检查4例均为筛状/管状型腺样囊性癌,3例累及甲状腺组织,3例累及神经组织,未见淋巴结受累。免疫组织化学染色示4例P16、CD117、BCL2、P63、SMA均阳性,Ki67指数平均8%,TTF1和P53均阴性;4例中基底膜样物胶原Ⅳ阳性;组织化学染色示AB/PAS阳性。术后均接受总剂量为48~56 Gy的放疗,随访6~120个月,平均72.5个月,1例术后96个月复发,3例随访期间无复发及转移。结论 气管上段腺样囊性癌是罕见的原发于气管的低度恶性肿瘤,肿瘤生长缓慢,就诊时多数已侵及甲状腺组织,需要与原发于甲状腺的恶性肿瘤相鉴别,特别是在甲状腺穿刺及术中冰冻检查时。结合电子喉气管镜下表现、典型的形态学及免疫组织化学和组织化学染色有助于准确诊断。手术难以切除干净,术后放疗对延缓疾病复发有一定帮助。 相似文献
15.
With the circulation of misinformation about the COVID-19 pandemic, the World Health Organization has raised concerns about an “infodemic,” which exacerbates people’s misperceptions and deters preventive measures. Against this backdrop, this study examined the conditional indirect effect of social media use and discussion heterogeneity preference on COVID-19-related misinformation beliefs in the United States, using a national survey. Findings suggested that social media use was positively associated with misinformation beliefs, while discussion heterogeneity preference was negatively associated with misinformation beliefs. Furthermore, worry of COVID-19 was found to be a significant mediator as both associations became more significant when mediated through worry. In addition, faith in scientists served as a moderator that mitigated the indirect effect of discussion heterogeneity preference on misinformation beliefs. That is, among those who had stronger faiths in scientists, the indirect effect of discussion heterogeneity preference on misinformation belief became more negative. The findings revealed communication and psychological factors associated with COVID-19-related misinformation beliefs and provided insights into coping strategies during the pandemic. 相似文献
16.
摘 要:目的 了解六六六(hexachlorocyclohexanes,HCHs)与滴滴涕(dichloro diphenyl trichloroethanes,DDTs)在杭州湾南岸滩涂沉积物中的污染现状。方法 于2018年4月,采集杭州湾南岸地区4个采样点不同深度(0~80 cm)滩涂沉积物,利用气相色谱-串联质谱法(gas chromatography tandem mass spectrometry, GC-MS/MS)测定了该区域中HCHs与DDTs的含量,对其分布规律进行分析,使用共识沉积物质量基准法对其生态学风险进行了评估。结果 所有样品中均检出,HCHs与DDTs含量分别为4.20~6.24 μg/kg与3.37~4.73 μg/kg,主要以β-HCH、δ-HCH以及DDE为主,其污染主要来源于历史性工业品,整体污染处于较低水平;20.3%的沉积物样品中DDEs含量以及28.1%的样品DDTs总量介于阈值效应浓度(threshold concentration, TECs) 和可能效应浓度(probable effect concentration, PECs)之间。结论 杭州湾南岸沉积物中HCHs与DDTs的污染处于较低水平,具有较小的生态学风险。 相似文献
17.
As the development of cloud computing and the convenience of wireless sensor netowrks, smart devices are widely used in daily life, but the security issues of the smart devices have not been well resolved. In this paper, we present a new NTRU-type public-key cryptosystem over the binary field. Specifically, the security of our scheme relies on the computational intractability of an unbalanced sparse polynomial ratio problem (DUSPR). Through theoretical analysis, we prove the correctness of our proposed cryptosystem. Furthermore, we implement our scheme using the NTL library, and conduct a group of experiments to evaluate the capabilities and consuming time of encryption and decryption. Our experiments result demonstrates that the NTRU-type public-key cryptosystem over the binary field is relatively practical and effective. 相似文献
18.
19.
Zhuang CHENG Jianfeng WANG Matthew Richard COOP Guanlin YE 《Frontiers of Structural and Civil Engineering》2020,14(2):357
The development of a miniature triaxial apparatus is presented. In conjunction with an X-ray micro-tomography (termed as X-ray μCT hereafter) facility and advanced image processing techniques, this apparatus can be used for in situ investigation of the micro-scale mechanical behavior of granular soils under shear. The apparatus allows for triaxial testing of a miniature dry sample with a size of (diameter height). In situ triaxial testing of a 0.4–0.8 mm Leighton Buzzard sand (LBS) under a constant confining pressure of 500 kPa is presented. The evolutions of local porosities (i.e., the porosities of regions associated with individual particles), particle kinematics (i.e., particle translation and particle rotation) of the sample during the shear are quantitatively studied using image processing and analysis techniques. Meanwhile, a novel method is presented to quantify the volumetric strain distribution of the sample based on the results of local porosities and particle tracking. It is found that the sample, with nearly homogenous initial local porosities, starts to exhibit obvious inhomogeneity of local porosities and localization of particle kinematics and volumetric strain around the peak of deviatoric stress. In the post-peak shear stage, large local porosities and volumetric dilation mainly occur in a localized band. The developed triaxial apparatus, in its combined use of X-ray μCT imaging techniques, is a powerful tool to investigate the micro-scale mechanical behavior of granular soils. 相似文献
20.
Manjunatha S. Muttigi Byoung Ju Kim Bogyu Choi Inbo Han Hansoo Park Soo-Hong Lee 《International journal of molecular sciences》2020,21(23)
Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for articular cartilage repair and regeneration. However, the terminal hypertrophic differentiation of Ad-MSC-derived cartilage is a critical barrier during hyaline cartilage regeneration. In this study, we investigated the role of matrilin-3 in preventing Ad-MSC-derived chondrocyte hypertrophy in vitro and in an osteoarthritis (OA) destabilization of the medial meniscus (DMM) model. Methacrylated hyaluron (MAHA) (1%) was used to encapsulate and make scaffolds containing Ad-MSCs and matrilin-3. Subsequently, the encapsulated cells in the scaffolds were differentiated in chondrogenic medium (TGF-β, 1–14 days) and thyroid hormone hypertrophic medium (T3, 15–28 days). The presence of matrilin-3 with Ad-MSCs in the MAHA scaffold significantly increased the chondrogenic marker and decreased the hypertrophy marker mRNA and protein expression. Furthermore, matrilin-3 significantly modified the expression of TGF-β2, BMP-2, and BMP-4. Next, we prepared the OA model and transplanted Ad-MSCs primed with matrilin-3, either as a single-cell suspension or in spheroid form. Safranin-O staining and the OA score suggested that the regenerated cartilage morphology in the matrilin-3-primed Ad-MSC spheroids was similar to the positive control. Furthermore, matrilin-3-primed Ad-MSC spheroids prevented subchondral bone sclerosis in the mouse model. Here, we show that matrilin-3 plays a major role in modulating Ad-MSCs’ therapeutic effect on cartilage regeneration and hypertrophy suppression. 相似文献