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101.
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Guowei Wang Chao Zhang Yifan Jiang Yue Song Jifan Chen Yu Sun Qunying Li Zhuxian Zhou Youqing Shen Pintong Huang 《Advanced functional materials》2021,31(34):2102786
Active tumor penetration has been recently recognized as a promising strategy to resolve the limitation of nanomedicine in terms of tumor penetration, but it is challenging to develop active transporting nanocarriers. Here, an ultrasonic cavitation-assisted and acid-activatable active transporting liposome for a broad range of tumors is reported. The active transporting liposome (size and charge dual-conversional gemcitabine prodrug-integrated liposomal nanodroplet (SCGLN)) overcomes the tight blood vessel walls with the aid of ultrasonic cavitation. The SCGLN subsequently transforms from micro-size to nano-size under prolonged ultrasound radiation. Once in the acidic tumor microenvironment, the nanosized SCGLN undergoes negative-to-positive charge-reversal and triggers the cationization-initiated transcytosis to penetrate deep into tumor parenchyma. The gemcitabine-loaded SCGLN exhibits potent antitumor activity in multiple poorly permeable tumor models, which completely erases subcutaneous U251 glioma and stops the progression of orthotopic BxPC3 pancreatic ductal adenocarcinoma. This study presents a promising and universal strategy to develop active penetrating nanomedicines for efficient drug delivery in the low permeable tumor. 相似文献
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A theoretical analysis on detonation wave propagation in a double-layer shaped charge (DLSC) is performed. Numerical simulations using the AUTODYN software are carried out to compare the distinctions between jet formations in DLSC and ordinary shaped charge (OSC), in particular, the OSC made using a higher detonation velocity explosive, which is treated as the outer layer charge in the DLSC. The results show that the improved detonation velocity ratio and radial charge percentage of outer-to-inner layer charge are conducive to the formation of a convergent detonation wave, which contributes to enhancement of jet tip velocity in DLSC. The thickness and mass percentages of liner flowing into jet in DLSC closely follow the exponential distribution along the radial direction, but the percentages in DLSC and the mass of effective jet, which have significant influence on the penetration depth, are lower than those in OSC with the outer layer charge. This implies that the total charge energy is the major factor controlling the effective jet formation, which is confirmed by the verification tests using flash X-ray system and following penetration tests. The numerical simulation and test results compare well, while penetration test results indicate that the performance of DLSC is not better than that of OSC with the outer layer charge, due to the differences in jet formation. 相似文献
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提议以网络中心战为背景构建网络对抗作战体系和效能评估体系。建议以"比特战"为切入点,引导现有通信对抗技术融合进入网络对抗技术体系,并以软件无线电和认知无线电为基础,发展网络对抗通用平台和系统,并兼顾专用平台和系统。由于"网络空间"的出现,战场网络对抗必然需要深入到网络内部,建议针对网络的开放性、复杂性和标准性,开展渗透攻击研究。 相似文献
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为考察枪弹打击下三明治型泡沫铝夹芯材料的防护性能,采用仿真分析与实弹打击试验相结合的方法,研究7.62 mm枪弹对不同面板配置泡沫铝夹芯材料的打击效果.结果表明:增加泡沫铝芯层后,金属层合材料的抗侵彻性能有大幅提升;入射、出射面板总厚度一致情况下,增大入射面板厚度能改善材料整体抗侵彻能力;入射和出射面板为Q235钢且芯层为均质泡沫铝时,在面板总厚度8 mm、芯层厚50 mm的结构配置下能够有效防护以735 m/s速度入射的7.62 mm步枪弹.该研究可为泡沫铝夹芯材料在军用装备抗弹防护中的应用提供参考. 相似文献
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为了研究浇注型高聚物黏结炸药(PBX?1)在侵彻过程中的安定性,开展155 mm火炮发射平头试验弹侵彻混凝土靶板试验,获得了该试验条件下装药安定的临界侵彻速度约为490 m·s^-1。基于黏弹性统计裂纹(Visco?SCRAM)模型,采用流固耦合方法模拟了安定性试验中装药的力学响应,计算了装药黏弹性变形和宏观裂纹损伤导致的温升。数值模拟结果与试验结果相一致,试验弹弹体侵彻后无明显的变形和破坏,但浇注PBX炸药在侵彻过载下发生大变形流动,部分装药从尾部缝隙挤出并发生了局部点火反应;侵彻过程中装药尾部会与药室底部发生高速碰撞,形成局部高压区,最高压力超过500 MPa,装药尾部变形和损伤严重,装药尾部在碰撞和挤出时,温度会急剧升高,从而导致意外点火。 相似文献
110.
PbS/CdS/ZnS Quantum Dots: A Multifunctional Platform for In Vivo Near‐Infrared Low‐Dose Fluorescence Imaging 下载免费PDF全文
Antonio Benayas Fuqiang Ren Elisa Carrasco Vicente Marzal Blanca del Rosal Belete A. Gonfa Ángeles Juarranz Francisco Sanz‐Rodríguez Daniel Jaque José García‐Solé Dongling Ma Fiorenzo Vetrone 《Advanced functional materials》2015,25(42):6650-6659
Over the past decade, near‐infrared (NIR)‐emitting nanoparticles have increasingly been investigated in biomedical research for use as fluorescent imaging probes. Here, high‐quality water‐dispersible core/shell/shell PbS/CdS/ZnS quantum dots (hereafter QDs) as NIR imaging probes fabricated through a rapid, cost‐effective microwave‐assisted cation exchange procedure are reported. These QDs have proven to be water dispersible, stable, and are expected to be nontoxic, resulting from the growth of an outer ZnS shell and the simultaneous surface functionalization with mercaptopropionic acid ligands. Care is taken to design the emission wavelength of the QDs probe lying within the second biological window (1000–1350 nm), which leads to higher penetration depths because of the low extinction coefficient of biological tissues in this spectral range. Furthermore, their intense fluorescence emission enables to follow the real‐time evolution of QD biodistribution among different organs of living mice, after low‐dose intravenous administration. In this paper, QD platform has proven to be capable (ex vivo and in vitro) of high‐resolution thermal sensing in the physiological temperature range. The investigation, together with the lack of noticeable toxicity from these PbS/CdS/ZnS QDs after preliminary studies, paves the way for their use as outstanding multifunctional probes both for in vitro and in vivo applications in biomedicine. 相似文献