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991.
Babur Ozcelik Mahmut Bayramoglu 《International Journal of Machine Tools and Manufacture》2006,46(12-13):1395-1402
Surface roughness is one of the most important requirements in machining process. The surface roughness value is a result of the tool wear. When tool wear increase, the surface roughness also increases. The determination of the sufficient cutting parameters is a very important process obtained by means of both minimum surface roughness values and long tool life. The statistical models were developed to predict the surface roughness.This paper presents the development of a statistical model for surface roughness estimation in a high-speed flat end milling process under wet cutting conditions, using machining variables such as spindle speed, feed rate, depth of cut, and step over. First- and second-order models were developed using experimental results of a rotatable central composite design, and assessed by means of various statistical tests. The highest coefficient of correlation (Radj2) (88%) was obtained with a 10-parameter second-order model. Meanwhile, a time trend was observed in residual values between model predictions and experimental data, reflecting the probable effect of the tool wear on surface roughness. Thus, in order to enhance the estimation capability of the model, another independent variable was included into the model to account for the effect of the tool wear, and the total operating time of the tool was selected as the most suitable variable for this purpose. By inserting this new variable as a linear term into the model, Radj2 was increased to 94% and a good fit was observed between the model predictions and supplementary experimental data.In this study, it was observed that, the order of significance of the main variables is as X5>X3>X4>X1>X2 (total machining time, depth of cut, step over, spindle speed and feed rate, respectively). 相似文献
992.
993.
994.
连铸中间包内三维湍流流动的数值模拟 总被引:11,自引:0,他引:11
连铸中间包的操作条件决定了其内流动现象的复杂性,为此,本文选择两种不同的湍流模型k-ε和LES(Largeeddysimulation),建立了描述连铸中间包内三维湍流流动的数学模型,并实施了数值计算和模型验证,对单流中间包内的流动现象进行了描述,考察了有,无流动控制情况下中间包内的流动特征和湍流模型的合理性,结果表明,合理的流动控制有利于中间包内非金属夹杂的上浮和吸附,用k-ε模型基本上能够描述 相似文献
995.
方柱体镦粗的两个新力学模型 总被引:8,自引:1,他引:8
在对平板间镦粗圆柱体的研究[1,2,3]基础上,进一步对普通平板间的方柱体镦粗,进行了工程力学的分析,提出了二个新力学模型,并进行了实验验证。这为形成新的拔长理论[4,6]奠定了力学基础。 相似文献
996.
ZHU Sheng CUI Pei-zhi YAO Ju-kun National Key Laboratory for Retnanufacturing Beijing China 《材料热处理学报》2004,25(5)
WITH the development of surface engineering andlaws on environment protect,lots of companies have toconsider reclaim of the used products.In practice,theyrealized if the products adopt design forremanufacturing,the benefit of remanufacturing wouldbe increased obviously'1'.Some researcher haveentered into remanufacturability field and built relativeevaluating methods'2'.Based on researching resultabout design for remanufacturing,some concepts,remanufacturability system and assessment method ar… 相似文献
997.
应用人工神经网络理论建立热粘塑性材料的本构关系 总被引:2,自引:1,他引:2
本文将人工神经网络(ANN)用于建立热粘塑性材料的本构关系,意在探索出一种描述材料变形力学行为的新方法。文中给出了应用人工神经网络建立热粘塑性材料本构关系的BP模型和学习算法过程,并应用于45号钢在高温和高速变形条件下的流动应力计算。计算结果与实测结果比较表明,二者吻合良好。因此,应用人工神经网络建立热粘塑性材料的本构关系具有重要的工程应用价值。 相似文献
998.
Marta Teixeira Pinto Ana Sofia Ribeiro Inês Conde Rita Carvalho Joana Paredes 《International journal of molecular sciences》2021,22(1)
The high plasticity of cancer stem-like cells (CSCs) allows them to differentiate and proliferate, specifically when xenotransplanted subcutaneously into immunocompromised mice. CSCs are highly tumorigenic, even when inoculated in small numbers. Thus, in vivo limiting dilution assays (LDA) in mice are the current gold standard method to evaluate CSC enrichment and activity. The chick embryo chorioallantoic membrane (CAM) is a low cost, naturally immune-incompetent and reproducible model widely used to evaluate the spontaneous growth of human tumor cells. Here, we established a CAM-LDA assay able to rapidly reproduce tumor specificities—in particular, the ability of the small population of CSCs to form tumors. We used a panel of organotropic metastatic breast cancer cells, which show an enrichment in a stem cell gene signature, enhanced CD44+/CD24−/low cell surface expression and increased mammosphere-forming efficiency (MFE). The size of CAM-xenografted tumors correlate with the number of inoculated cancer cells, following mice xenograft growth pattern. CAM and mice tumors are histologically comparable, displaying both breast CSC markers CD44 and CD49f. Therefore, we propose a new tool for studying CSC prevalence and function—the chick CAM-LDA—a model with easy handling, accessibility, rapid growth and the absence of ethical and regulatory constraints. 相似文献
999.
Equivalent model of multi-type distributed generators under faults with fast-iterative calculation method based on improved PSO algorithm 下载免费PDF全文
Puyu Wang Jinyuan Song Fangyu Liang Fang Shi Xiangping Kong Guangen Xie Xiao-Ping Zhang Xinxin Gu 《电力系统保护与控制》2021,6(3):371-382
There are various types of distributed generators (DGs) with diferent grid integration strategies. The transient char?
acteristics of the fault currents provided by the DGs are diferent to those of conventional synchronous generators. In
this paper, a distribution network with multi-type DGs is investigated, including consideration of DG low-voltage ride
through (LVRT). The fault current characteristics of two typical DGs, i.e. an inverter-interfaced distributed generator
(IIDG) and a doubly-fed induction generator (DFIG), are analyzed, considering the specifc operation modes. Based on
analysis of the fault characteristics, an equivalent model of the multi-type DGs under symmetrical/asymmetrical fault
conditions is established. A fast-iterative fault calculation method for enhancing the calculation efciency while avoid?
ing local convergence is then proposed using an improved particle swarm optimization (PSO) algorithm. A simula?
tion system of the distribution network with multi-type DGs is established in PSCAD/EMTDC. The simulation results
validate the high accuracy and calculation efciency of the proposed calculation method of the fault components.
This can assist in the settings of the protection threshold. 相似文献
1000.
Nadine Reichhart Vladimir M. Milenkovic Christian H. Wetzel Olaf Strauß 《International journal of molecular sciences》2021,22(5)
The anoctamin (TMEM16) family of transmembrane protein consists of ten members in vertebrates, which act as Ca2+-dependent ion channels and/or Ca2+-dependent scramblases. ANO4 which is primarily expressed in the CNS and certain endocrine glands, has been associated with various neuronal disorders. Therefore, we focused our study on prioritizing missense mutations that are assumed to alter the structure and stability of ANO4 protein. We employed a wide array of evolution and structure based in silico prediction methods to identify potentially deleterious missense mutations in the ANO4 gene. Identified pathogenic mutations were then mapped to the modeled human ANO4 structure and the effects of missense mutations were studied on the atomic level using molecular dynamics simulations. Our data show that the G80A and A500T mutations significantly alter the stability of the mutant proteins, thus providing new perspective on the role of missense mutations in ANO4 gene. Results obtained in this study may help to identify disease associated mutations which affect ANO4 protein structure and function and might facilitate future functional characterization of ANO4. 相似文献