The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder.

Obsessive Compulsive Disorder (OCD) is currently treated with behavioral modification and psychotropic medications, with varying degrees of success. The most popular drugs for the treatment of OCD are the selective serotonin reuptake inhibitors (SSRIs). Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. The present study investigates the effect of fluoxetine and memantine alone and in combination in a mouse model of compulsive behavior. In this model, compulsive scratching is induced by a subcutaneous injection of serotonin or a serotonin releasing agent, compound 48–80, in the back of the neck. The effects of the memantine and fluoxetine combination were found to synergistic, specifically as defined by an isobologram. The results of the present investigation suggest the potential of a more effective management of the symptoms of OCD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

正则表达式在网络信息监控分析系统中的应用

在网络信息监控系统中,利用正则表达式和HTMLparser对网页HTML代码进行递规匹配,实现了对网站的整体解析.实际应用表明,新信息从发布到抓取的时间小于5分钟,没有出现信息漏抓、不抓和重复抓取的现象.系统利用Java语言实现,准确率和遗漏率分别达到99%和0.     

斜井提升自动监测捕车吸能装置的设计

在煤矿的生产系统中,矸石提升、材料及设备运输绝大部分要通过斜井提升来完成。捕车吸能装置对煤矿斜井提升来说是一种较先进、经济实用和可靠性较高的安全装置,介绍斜井提升自动监测捕车吸能装置的设计。     

THE EFFECT OF W ON THE REPASSIVATION BEHAVIOR OF Ni-ADDED STAINLESS STEELS

The effect of W on the repassivation behavior of Ni-added stainless steels was investigated with respect to the repassivation rate and the SCC susceptibility. It was found that more stable passive film was formed on the W-modified stainless steels than that of steels without W-modification, and the repassivation rate was faster for W-modified stainless steels in acidic chloride solution （0.5M H2SO4＋3.5% Cl^-）. In neutral chloride solution （1M MgCl2）, there were no significant differences on both passivation properties and the repassivation rates for duplex stainless steels, while W-modified austenite stainless steel showed faster repassivation rate. The SCC tests verified that W-modified Ni-added stainless steels exhibited better SCC resistance than steels without W in chloride solution. Moreover, W-modification in higher Ni-added stainless steels exhibited more remarkable SCC resistance than steels with lower Ni content in chloride solution.     

Evaluation of a Lightly Scratched Amorphous Carbon Surface by Contact Resistance of a Conductive Diamond Tip and the Carbon Surface

An electron-cyclotron-resonance-sputtered amorphous carbon film is scratch-scanned by an AFM and a conductive diamond tip at small contact loads (2N). The electrical contact resistance between the tip and the scratched carbon surface increases upon increasing the scratching load and the number of scratching scans and decreases with increasing scratching velocity. The wear depth is less than 0.6 nm in all scratching experiments and is almost independent of the scratching load, the number of scratching scans and the scratching velocity. The change in contact resistance caused by the scratching is affected by environmental humidity. The magnitude of the change in the contact resistance is almost the same at 20 and 50% RH and increases with increasing relative humidity at humidities higher than 50% RH. The contact resistance also increases upon scratching in vacuum. The change in contact resistance is thought to be caused by tribochemical oxidation of the rubbed surface by humid air and also destruction of the graphite structure of the ECR-sputtered carbon surface.     

膜—基界面结合状况应力—应变诊析技术研究

开发新的膜—基界面结合强度定量检测技术是目前薄膜技术科研人员普遍关注的热点问题。本文提出了表征膜—基界面结合强度的红外激光划痕检测新技术。界面结合状况诊析技术研究和激光划痕机理是该项新技术的两大关键问题 ,本文在研究激光划痕过程中膜—基系统界面结合状况变化规律的基础上 ,探讨了界面结合状况应力—应变诊析技术 ,提出以脱粘层开始发生弹性失稳翘曲的时刻作为激光划痕膜—基界面破坏临界点的诊析判据。     

品检机走纸不稳振动分析与优化

为了解决品检机走纸过程中出现的纸张划伤问题,对给纸部的传送皮带进行数学建模。采用MATLAB分析皮带的横向振动,根据皮带的幅值变化调节撑杆与皮带之间的距离,从而避免由纸张与撑杆接触产生的划伤问题。为进一步确保纸张在走纸过程中不会接触到撑杆,从撑杆底部向下吹气,通过调节气量的大小来控制纸张划伤率。试验结果表明,该方案有效地解决了品检机的走纸划伤问题,在很大程度上提高了印品的合格率。     

高体积分数SiCp/Al复合材料旋转超声铣磨加工的试验研究

由于大量高硬度增强相SiC颗粒的存在,高体积分数铝基碳化硅（SiCp/Al）复合材料的机械加工十分困难。旋转超声加工被认为是加工这种材料的有效方法。通过超声辅助划痕试验,分析高体积分数SiCp/Al复合材料旋转超声铣磨加工的材料去除机理。在超声振动的作用下,材料中铝基体发生塑性变形,其表面得到夯实;SiC增强相被锤击成细小的颗粒而发生脱落,形成较大的空洞。由于材料加工的缺陷大多产生于SiC颗粒的去除过程中,SiC颗粒的去除方式对加工表面的质量起着决定性的作用,选择合适的工艺参数可以有效提高加工表面质量。旋转超声加工工艺特征试验表明,超声振动可有效降低切削力;主轴转速对轴向切削力的影响最大,其次是进给速度,切削深度对轴向切削力的影响较小;另外主轴转速对表面质量的影响效果也最大,并随主轴转速的增大表面粗糙度增大。因此在加工过程中,可以适当加大切削深度,在保证加工质量的基础上,选择较大的进给速度,在保证刀具寿命的前提下,选择合适的主轴转速,以获得较优的加工表面质量和加工效率。     

AFM光杠杆系统在刻划深度控制中的应用分析

应用AFM组建三维刻划加工系统,光杠杆系统是实现刻划深度控制的重要环节．通过分析微悬臂挠度、转角对光杠杆系统的影响,及不同刻划方向针尖扭转角对刻划深度的影响,得出以下结论：由非刚性微悬臂组成的光杠杆系统,与理想光杠杆系统存在3：2的线性检测变换关系,可采用单点标定方法对光杠杆系统进行标定;沿相对于微悬臂长轴进行横向刻划时针尖扭转角所产生的刻划深度误差,远小于沿纵向刻划所产生的刻划深度误差．     

Engineering dislocation-rich plastic zones in ceramics via room-temperature scratching

In this communication, we demonstrate a simple but powerful method to engineer dislocations into large plastic zones in various single-crystal ceramic materials via room-temperature scratching. By using a Brinell indenter with a diameter of 2.5 mm, we successfully produced plastic zones with a width and depth of ∼150 µm in a single scratch track, while the length of the scratch track can be arbitrarily long depending on the sample size. Increasing the number of repetitive scratching cycles increases the dislocation density up to ∼10¹³ m⁻² without visible crack formation. The outlined experimental procedure is showcased on single-crystal SrTiO₃, MgO, ZnS, and CaF₂ to demonstrate the general applicability of this technique. In light of the increasing research interest in dislocation-tuned functional and mechanical properties in ceramics, our method will serve as a simple, fast, and robust technique to pave the road for scaling up the required large plastic zones for dislocation engineering in ceramics.