Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery,Cellular Imaging,and Stimuli‐Responsive Materials

Trimethyl lock (TML) systems are based on ortho‐hydroxydihydrocinnamic acid derivatives displaying increased lactonization reactivity owing to unfavorable steric interactions of three pendant methyl groups, and this leads to the formation of hydrocoumarins. Protection of the phenolic hydroxy function or masking of the reactivity as benzoquinone derivatives prevents lactonization and provides a trigger for controlled release of molecules attached to the carboxylic acid function through amides, esters, or thioesters. Their easy synthesis and possible chemical adaption to several different triggers make TML a highly versatile module for the development of drug‐delivery systems, prodrug approaches, cell‐imaging tools, molecular tools for supramolecular chemistry, as well as smart stimuliresponsive materials.     

Aggregation‐Enhanced Emission of Fluorescent‐Gemini Surfactants with High Photostability for Cell‐Membrane Imaging

In situ studies of the aggregation behavior of traditional surfactants at the liquid interface using spectroscopic methods are often significantly affected by the large volume of fluorescent groups, such as pyrene. Fluorescent‐Gemini surfactants provide an ideal solution since the fluorescent block can be designed as a spacer or a tail. In this work, we report the synthesis of a new fluorescent‐Gemini surfactant with a rigid spacer (referred to as 8‐TBT‐8). The aggregation behavior and application in cell‐membrane imaging were investigated. The unique aggregation behavior in an organic solvent and aqueous solution was studied using spectroscopy. UV–vis and photoluminescence spectra of 8‐TBT‐8 revealed that this new fluorescent surfactant forms H aggregates in organic solution to give blue emission, whereas it forms J aggregates in aqueous solution to give green fluorescence under UV light. In addition, the fluorescence intensity of 8‐TBT‐8 increases abruptly at concentrations higher than the critical micellization concentration. Good photostability and a unique structure make the synthesized Gemini surfactant very suitable for membrane imaging.     

数字全息在线测量煤粉粒度分布

煤粉粒度是燃煤电厂的重要指标,在线测量煤粉粒度能够即时指导锅炉优化运行,对节能减排具有重要意义。搭建了一套模拟一次风粉管道的煤粉粒径在线测量的装置,解决了传统取样方法堵塞和测量实时性差的问题,并设计实验研究数字全息在线测量煤粉粒度的可行性和可靠性。实验结果表明,数字全息在线测量煤粉粒度分布曲线与激光粒度仪的测量曲线趋势一致,平均粒径相对误差为5.6%,表征粒度分布的关键参数d₅₀和d₉₀的相对误差均低于2%,满足工业应用的需求。数字全息技术对稀释前后不同浓度的煤粉粒径关键参数的测量相对误差均低于7%,稀释前后的煤粉粒度的数量分布和体积曲线的趋势一致,验证了数字全息技术在线测量煤粉粒度分布的可靠性,为整体测量装置的开发奠定了基础。     

Measurements of horizontal three‐phase solid‐liquid‐gas slug flow: Influence of hydrate‐like particles on hydrodynamics

Gas hydrate formation is a main flow assurance concern in oil and gas production. Understanding the effects of the introduction of solid particles in the slug flow is essential to improve the efficiency and safety of multiphase production. The purpose of the present work is the experimental characterization of solid‐liquid‐gas slug flow with the presence of dispersed hydrate‐like particles. Experimental tests were carried out with inert polyethylene particles of 0.5‐mm diameter with density similar to gas hydrates (938 kg/m³). The test section comprised a 26‐mm ID, 9‐m length horizontal duct of transparent Plexiglas. High Speed Imaging and resistivity sensors was used to analyze the slug flow unit cell behavior due to the introduction of the solid particles and to measure the unit cell translational velocity, the slug flow frequency, the bubble and slug lengths, and the phase fractions. Two distinct concentrations of solid particles were tested (6 and 8 g/dm³). © 2018 American Institute of Chemical Engineers AIChE J, 64: 2864–2880, 2018     

MR imaging of focal liver lesions: comparison between turbo spin-echo and conventional spin-echo pulse sequences

The aim of this study was to compare conventional spin-echo (CSE)T ₂-weighted (T2W) images with turbo spin-echo (TSE) T2W pulse sequences in their ability to detect focal liver lesions. Seventy-eight consecutive patients with focal liver lesions were entered into this study. All patients were imaged using the gradient-echo (GE) sequence with the breath-hold technique forT ₁-weighted (T1W) images, and CSE and TSE sequences for T2W images. Qualitative evaluation included lesion detection (number of lesions detected) and conspicuity (extent of visualization of lesional borders); quantitative evaluation included the signal-to-noise (S/N) ratio and the contrast-to-noise (C/N) ratio. TSE showed the best performance in terms of lesion detection; however, the difference between TSE and CSE was significant only in the case of benign cysts (p<0.01). Conspicuity was higher with TSE and CSE, and lower with GE. The S/N and C/N ratios of the two T2W sequences were also comparable, and better than those of GE. However, the combined use of GE and TSE resulted in improved lesion detection. The results show that, because the acquisition time is greatly reduced with TSE sequences, these should be considered as first-line approach to magnetic resonance imaging of the liver for the study of focal lesions.     

Design of the broadband microstrip array antenna for blast furnace surface monitoring

Aiming at the requirements of high-resolution imaging and high integration of the blast furnace radar,this paper presents a method for designing a wideband microstrip array antenna,which broadens the antenna bandwidth through the design of parasitic patches and air layers.By combining multi-input multi-output (MIMO) radar and synthetic aperture radar (SAR) imaging principles,a linear MIMO array is designed,and a near-field simulation imaging experiment is performed on the simulated feed line through the wave number domain imaging algorithm.Simulation results show that the gain of the main lobe of the antenna can reach 14.05 dBi,the reflection coefficient is less than -10 dB,the absolute bandwidth is 5.25 GHz,the operating frequency is 20.67~25.92 GHz,and the range resolution is increased to 3 cm compared with the existing blast furnace radar.The average error of the azimuth direction of the simulated material line imaging is 0.008 m,and the range direction is 0.0011 m.Compared with the traditional microstrip array antenna,this antenna effectively widens the bandwidth,and the range resolution is higher than that of the traditional blast furnace radar.It can accurately obtain the shape information on the simulated material line,and has an engineering application value for blast furnace surface monitoring.     

水工混凝土构件裂缝检测方法及应用

水利工程在长期运行过程中,其混凝土构件会出现磨蚀、裂缝等损伤,如这类问题不能够及时得到处理,将会严重影响水利工程的安全运行。本次研究主要针对水工混凝土构件中的裂缝检测方法进行研究,提出从“定性”到“定量”的一体化检测思路,具体实施过程分为四部分,即“普探—详查—判定—验证”,其中,普探阶段采用探地雷达法,确定裂缝的总体分布;详查阶段采用超声横波反射三维成像的方法,确定裂缝的纵深向分布;判定阶段分别采用裂缝测宽法和表面声波法,用来确定裂缝的表面宽度和贯穿深度;验证采用钻孔电视,确定探测结果的正确性和准确性。上述技术路线突破了单一方法的限制,可有效地运用于水工混凝土构件裂缝检测,经实践证实,具有良好的检测效果。     

密集观测场景下的敏捷成像卫星任务规划方法

针对密集观测场景下敏捷成像卫星任务规划问题求解空间大、输入任务序列较长的特点,综合考虑时间窗口约束、任务转移时卫星姿态调整时间、存储约束和电量约束,对敏捷成像卫星任务规划问题进行建模. 提出融合IndRNN和Pointer Networks的算法模型（Ind-PN）对敏捷成像卫星任务规划问题进行求解,使用多层的IndRNN结构作为算法模型的解码器. 基于Pointer Networks机制对输入任务序列进行选择,使用Mask向量考虑敏捷成像卫星任务规划问题中的各类约束. 基于Actor Critic强化学习算法对算法模型进行训练,以获得最大的观测收益率. 实验结果表明,对于密集观测场景下的任务规划,Ind-PN算法的收敛速度更快,可以获得更高的观测收益率.     

机载对海多目标ISAR成像系统设计

机载对海逆合成孔径雷达(inverse synthetic aperture radar,ISAR)能够对海面大中型舰船进行二维成像,图像信息为识别提供了更有利的依据.根据ISAR系统的工作原理,首先分析了对海多目标ISAR面临的关键问题;然后提出了空间、时间两维分割的处理方案,以解决不同海况下海面多目标成像分辨率的问...