Chromophore-Free Sealing and Repair of Soft Tissues Using Mid-Infrared Light-Activated Biosealants

Poor strength, infection, leakage, long procedure times, and inflammation limit the efficacy of common tissue sealing devices in surgeries and trauma. Light-activated sealing is attractive for tissue sealing and repair, and can be facilitated by the generation of local heat following absorption of nonionizing laser energy by chromophores. Here, the inherent ability of biomaterials is exploited to absorb nonionizing, mid-infrared (midIR) light in order to engender rapid photothermal sealing and repair of soft tissue wounds. In this approach, the biomaterial simultaneously acts as a photothermal convertor as well as a biosealant, which dispenses the need for exogeneous light-absorbing nanoparticles or dyes. Biomechanical recovery, mathematical modeling, histopathology analyses, tissue strain mapping using digital imaging correlation, and visualization of the biosealant-tissue interface using hyperspectral imaging indicate superior performance of midIR sealing in live mice compared to conventional sutures and glue. The midIR-biosealant approach demonstrates rapid sealing of soft tissues, improves cosmesis, lowers potential for scarring, obviates safety concerns because of the nonionizing light used, and allows adoption of a wide diversity of biomaterials. Taken together, the studies demonstrate a novel advance both in biomaterials for surgical sealing along with the use of nonionizing midIR light, with high potential for clinical translation.     

Calcium phosphates grown on bacterial cellulose template

Bacterial cellulose membranes were employed as templates for calcium phosphates deposition by successive immersion in solutions of Ca(NO₃)₂·4H₂O and (NH₄)₂HPO₄, under ultrasonication. During the wet chemical reaction, mineral phases were loaded on bacterial cellulose fibrils, leading to precursor hybrid composites. These were subjected to a lyophilisation procedure in order to preserve the 3D porous aspect and afterwards to a thermal treatment with the aim of removing the polymeric phase and generating well crystallized structures. Different types of morphologies were achieved by varying the heating rate, as well as the calcination temperature and period. The as-prepared samples and the final ones were investigated from compositional and structural point of view through X-ray diffraction and Fourier-transform infrared spectroscopy and morphologically concerning by scanning electron microscopy. The magnetic properties were also evaluated in order to demonstrate the suitability of the obtained materials for the development of magnetic scaffolds dedicated to hard tissue applications.     

面向对象系统中的特性表机制与复合对象

本文主要讨论特性表机制与复合对象的概念、功能及实现．在基于知识的面向对象系统中引入特性表机制与复合对象概念的目的在于增强系统的知识表达能力．文中提出的特性表机制包括了三种类型的特性说明表：类说明特性表、继承关系特性表和变量特性说明表．复合对象在系统中是通过引入一个称为“影子类”的新概念来构造和实现的．     

The effects of glycol methacrylate as a dehydrating agent on the dimensional changes of liver tissue

The dimensional changes of liver sections during the course of processing with glycol methacrylate (GMA) or with ethanol are described. Tissue processing with ethanol served as a control. During prolonged processing steps (24 h each), linear shrinkage of tissue specimens dehydrated with GMA at room temperature was 13.2%. Subsequent infiltration with GMA resulted in trivial swelling, and polymerization in slight shrinkage (2.3%). In comparison, processing with cold GMA resulted in shrinkage during dehydration (about 10.8%), a slight swelling in pure GMA, followed by shrinkage during polymerization (2.2%). Short routine processing schedules resulted in similar shrinkage/swelling patterns, although precise values differed slightly. In all experiments, ethanolic dehydration resulted in smaller dimensional tissue changes than did GMA dehydration. The dimensional changes of tissue sections during stretching on water, mounting and drying compensated for the major part of the shrinkage manifested during processing.     

结构设计软件应用中应注意的问题

针对目前结构设计软件应用存在的问题,提出了解决这些问题的途径,指出结构工程师应注重概念设计,并应处理好结构与结构、结构与构件和构件之间的关系,确定好细部构造的做法,以期结构工程师提高自身素质,发挥其主动性和创新精神。     

浅谈造价工程师的执业能力

我国的工程造价管理体系正在逐步规范，并建立以市场形成价格为主的价格体制；改革现行工程定额管理方式，这些对造价工程师的执业能力和水平提出了更高的要求。造价工程师面临机遇、挑战，必须不断调整知识结构，提高整体素质，拓展个人在专业领域的空间。     

随钻气侵检测仪在胜利油田的应用

简要介绍了随钻气侵检测仪的结构特点、工作原理、现场模拟试验及应用情况。中原油田全尺寸实验井和胜利油田６口井的现场试验及应用结果表明，该仪器能实现早期气侵检测，比常规方法检测到气侵的时间明显提前，对高压气井和复杂地层井控具有重要的现实意义。     

骨组织工程PLGA/TCP复合材料的性能研究

骨组织工程的支架要求有与人骨在功能梯度上相一致的材料结构、几何结构和生理功能。PLGA／TCP复合材料具有适用于骨组织工程支架的综合性能。以快速成形技术低温沉积工艺的成形效果来评价材料的成形性能，以体外降解试验来评价材料的降解性能，以国家标准的方法来评价材料的细胞毒性，对PLGA和TCP不同配比下的性能进行了研究，发现TCP含量的增加有利于降低材料的细胞毒性，加快了材料的降解，但同时降低了材料的成形性能。从骨组织工程的临床应用来看，低的细胞毒性是需要首先得到保证的，成形性能则通过其他方式来改善。     

雏议造价监理工程师在工程建设中的作用

分析了造价监理工程师如何在在施工前期的招投标、施工组织方案技术经济评价和工程施工阶段的签证、索赔、进度款控制等方面对造价进行合理确定和有效控制。     

γ射线对叶组织电阻变化的影响及动态分析

测试了水稻和烟草两种叶片经不同剂量的^60Co γ射线辐照处理后，组织电阻及离子外渗的动态变化情况。研究结果表明：当超过一定的剂量阈值后，随着辐照剂量的增加，两种植物的叶组织电阻均呈现先上升、后下降的变化规律；叶组织电阻的改变与离子外渗的变化趋势并不一致；用测量叶组织电阻的方法可以较灵敏地体现出植物对γ射线的动态反应情况。运用电生理学的基础理论对上述生理现象的产生原因从机理上进行了分析与探讨。