Pro/engineer在产品曲面造型设计中的实现与评估

以产品曲面设计评估技术要求为依据,从技术应用角度论述pro/engineer软件在产品曲面设计中的构建方法和检测手段。从而证明pro/engineer在产品曲面设计中的应用可缩短产品的设计过程。     

虚拟手术仿真中人体软组织形变技术的研究

对虚拟手术仿真中人体软组织形变技术进行深入研究,利用OpenGL三维图形标准建立了基于质点-弹簧物理模型的虚拟人体软组织形变系统。围绕虚拟手术仿真中人体软组织形变的逼真度和实时性两大要素展开研究,通过对比四边形网格结构提出了改进的基于质点-弹簧模型的正六边形几何拓扑结构,并对软组织形变动力学模型及其数值积分算法、软组织形变力反馈计算模型进行了讨论,针对以往的虚拟手术器械与软组织表面接触时作用点的最近邻质点求取算法存在的不足,提出了改进的求取算法。实验结果表明,改进的算法在模拟软组织形变时具有较好的稳定性和实时性。     

Marine-Derived Hydrogels for Biomedical Applications

Marine organisms provide novel and broad sources for the preparations and applications of biomaterials. Since the urgent requirement of bio-hydrogels to mimic tissue extracellular matrix (ECM), the natural biomacromolecule hydrogels derived from marine sources have received increasing attention. Benefiting from their outstanding bioactivity and biocompatibility, many attempts have been made to reconstruct ECM components by applying marine-derived natural hydrogels. Moreover, marine hydrogels have been successfully applied in biomedicine by means of microfluidics, electrospray, and bioprinting. In this review, the classification and characteristics of marine-derived hydrogels are summarized. In particular, their role in the development of biomaterials is also introduced. Then, the recent advances in bio-fabrication strategies for various hydrogel materials are focused upon. Besides, the influences of hydrogel types on their functions in biomedical applications are discussed in depth. Finally, critical reflections on the limitations and future development of marine-derived hydrogels are presented.     

Multiphoton Lithography as a Promising Tool for Biomedical Applications

Multiphoton lithography (MPL) is a powerful and useful structuring tool capable of generating 2D and 3D arbitrary micro- and nanometer features of various materials with high spatial resolution down to nm-scale. This technology has received tremendous interest in tissue engineering and medical device manufacturing, due to its ability to print sophisticated structures, which is difficult to achieve through traditional printing methods. Thorough consideration of two-photon photoinitiators (PIs) and photoreactive biomaterials is key to the fabrication of such complex 3D micro- and nanostructures. In the current review, different types of two-photon PIs are discussed for their use in biomedical applications. Next, an overview of biomaterials (both natural and synthetic polymers) along with their crosslinking mechanisms is provided. Finally, biomedical applications exploiting MPL are presented, including photocleaving and photopatterning strategies, biomedical devices, tissue engineering, organoids, organ-on-chip, and photodynamic therapy. This review offers a helicopter view on the use of MPL technology in the biomedical field and defines the necessary considerations toward selection or design of PIs and photoreactive biomaterials to serve a multitude of biomedical applications.     

Three Potential Elements of Developing Nerve Guidance Conduit for Peripheral Nerve Regeneration

Autograft replaced by a nerve guidance conduit (NGC) is challenging in peripheral nerve injury because current NGC is still limited by precise conductivity and excellent biocompatibility in vivo, which influences the peripheral nerve repair even for a long lesion gap repair. Several particular elements have the potential function for nerve conductivity acceleration based on the traditional three factors of neural tissue engineering. The review aims to address three questions: 1) What is the superior factor for nerve conduction in the application? 2) How can a more conductive regenerative scaffold be constructed in vivo? 3) What is the next step in nerve regeneration for NGC? The bibliometrics analysis of NGC-related references is adopted to acquire that the conductive material, manufacturing technology of neural scaffold, and electrical stimulation (ES) play essential roles in the acceleration of nerve conduction. This review visually analyses the research status and summarizes the main types of conductive materials, the manufacturing technologies of neural scaffolds, and the characteristics of ES. The viewpoints and outlook of developing NGC are also discussed in this review. The proposed three elements are expected to improve the nerve conduction of NGC in vivo and even address the dilemma of long-distance peripheral nerve injury.     

Microscale Electro‐Hydrodynamic Cell Printing with High Viability

Cell printing has gained extensive attentions for the controlled fabrication of living cellular constructs in vitro. Various cell printing techniques are now being explored and developed for improved cell viability and printing resolution. Here an electro‐hydrodynamic cell printing strategy is developed with microscale resolution (<100 µm) and high cellular viability (>95%). Unlike the existing electro‐hydrodynamic cell jetting or printing explorations, insulating substrate is used to replace conventional semiconductive substrate as the collecting surface which significantly reduces the electrical current in the electro‐hydrodynamic printing process from milliamperes (>0.5 mA) to microamperes (<10 µA). Additionally, the nozzle‐to‐collector distance is fixed as small as 100 µm for better control over filament deposition. These features ensure high cellular viability and normal postproliferative capability of the electro‐hydrodynamically printed cells. The smallest width of the electro‐hydrodynamically printed hydrogel filament is 82.4 ± 14.3 µm by optimizing process parameters. Multiple hydrogels or multilayer cell‐laden constructs can be flexibly printed under cell‐friendly conditions. The printed cells in multilayer hydrogels kept alive and gradually spread during 7‐days culture in vitro. This exploration offers a novel and promising cell printing strategy which might benefit future biomedical innovations such as microscale tissue engineering, organ‐on‐a‐chip systems, and nanomedicine.     

Anisotropic Materials for Skeletal‐Muscle‐Tissue Engineering

Repair of damaged skeletal‐muscle tissue is limited by the regenerative capacity of the native tissue. Current clinical approaches are not optimal for the treatment of large volumetric skeletal‐muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle tissue. A typical tissue‐engineering process involves the design and fabrication of a scaffold that closely mimics the native skeletal‐muscle extracellular matrix (ECM), allowing organization of cells into a physiologically relevant 3D architecture. In particular, anisotropic materials that mimic the morphology of the native skeletal‐muscle ECM, can be fabricated using various biocompatible materials to guide cell alignment, elongation, proliferation, and differentiation into myotubes. Here, an overview of fundamental concepts associated with muscle‐tissue engineering and the current status of muscle‐tissue‐engineering approaches is provided. Recent advances in the development of anisotropic scaffolds with micro‐ or nanoscale features are reviewed, and how scaffold topographical, mechanical, and biochemical cues correlate to observed cellular function and phenotype development is examined. Finally, some recent developments in both the design and utility of anisotropic materials in skeletal‐muscle‐tissue engineering are highlighted, along with their potential impact on future research and clinical applications.     

缅甸七星塘矿山孔底间隔装药技术的实验与应用

为了解决缅甸七星塘矿山在开采爆破中含水孔装药施工困难的问题,采取了孔底间隔装药技术。根据孔底间隔装药爆破机理,参考目前已有的研究成果及应用参数,结合本矿山开采爆破的情况,进行现场实验,确定了孔底间隔装药技术的实施原则:控制最大间隔长度和最小药柱高度,获得了最大间隔长度为炮孔孔深的21.7%,药柱高度减少比例最多为30%的数据。采用孔底间隔装药技术解决了缅甸七星塘矿山开采爆破中含水孔装药施工的困难,同时获得了良好的爆破效果及经济效益,为孔底间隔装药技术在其他矿山解决类似问题提供了经验。