It is foreseen that more and more music objects in symbolic format and multimedia objects, such as audio, video, or lyrics,
integrated with symbolic music representation (SMR) will be published and broadcasted via the Internet. The SMRs of the flowing songs or multimedia objects will form a
music stream. Many interesting applications based on music streams, such as interactive music tutorials, distance music education, and
similar theme searching, make the research of content-based retrieval over music streams much important. We consider multiple
queries with error tolerances over music streams and address the issue of approximate matching in this environment. We propose
a novel approach to continuously process multiple queries over the music streams for finding all the music segments that are
similar to the queries. Our approach is based on the concept of n-grams, and two mechanisms are designed to reduce the heavy
computation of approximate matching. One mechanism uses the clustering of query n-grams to prune the query n-grams that are
irrelevant to the incoming data n-gram. The other mechanism records the data n-gram that matches a query n-gram as a partial
answer and incrementally merges the partial answers of the same query. We implement a prototype system for experiments in
which songs in the MIDI format are continuously broadcasted, and the user can specify musical segments as queries to monitor
the music streams. Experiment results show the effectiveness and efficiency of the proposed approach. 相似文献
Traditionally, standard Lagrangian-type finite elements, such as linear quads and triangles, have been the elements of choice
in the field of topology optimization. However, finite element meshes with these conventional elements exhibit the well-known
“checkerboard” pathology in the iterative solution of topology optimization problems. A feasible alternative to eliminate
such long-standing problem consists of using hexagonal (honeycomb) elements with Wachspress-type shape functions. The features
of the hexagonal mesh include two-node connections (i.e. two elements are either not connected or connected by two nodes),
and three edge-based symmetry lines per element. In contrast, quads can display one-node connections, which can lead to checkerboard;
and only have two edge-based symmetry lines. In addition, Wachspress rational shape functions satisfy the partition of unity
condition and lead to conforming finite element approximations. We explore the Wachspress-type hexagonal elements and present
their implementation using three approaches for topology optimization: element-based, continuous approximation of material
distribution, and minimum length-scale through projection functions. Examples are presented that demonstrate the advantages
of the proposed element in achieving checkerboard-free solutions and avoiding spurious fine-scale patterns from the design
optimization process. 相似文献
External insulin administration is an effective way for patients with diabetes mellitus to regulate their blood glucose. Multiple daily injections (MDIs), sensor-augmented pump (SAP) and artificial pancreas (AP) are widely adopted approaches in insulin therapy. With the increasing popularity of continuous glucose monitoring (CGM) sensors, a large number of data-enabled learning and control algorithms have been developed for MDI, SAP and AP. In this paper, we perform a systemic review concerning the state-of-the-art methodologies that are developed for MDI, SAP and AP with feedback from CGM data or other available data, from a systems and control perspective. The review characterizes the traditional learning and control methods developed for the MDI, SAP and AP, including run-to-run control, proportional–integral–derivative control, fuzzy logic control and model predictive control, as well as the discussions on the roles of machine learning technologies in MDI, SAP and AP. Finally, potential future directions on the algorithm architecture design, a unified control framework for MDI, SAP and AP algorithm design and practical usage of the MDI, SAP and AP are discussed. 相似文献
Context: Continuous processing is an innovative production concept well known and successfully used in other industries for many years. The modern pharmaceutical industry is facing the challenge of transition from a traditional manufacturing approach based on batch-wise production to a continuous manufacturing model.
Objective: The aim of this article is to present technological progress in manufacturing based on continuous and semi-continuous processing of the solid oral dosage forms.
Methods: Single unit processes possessing an alternative processing pathway to batch-wise technology or, with some modification, an altered approach that may run continuously, and are thus able to seamlessly switch to continuous manufacturing are briefly presented. Furthermore, the concept of semi-continuous processing is discussed. Subsequently, more sophisticated production systems created by coupling single unit processes and comprising all the steps of production, from powder to final dosage form, were reviewed. Finally, attempts of end-to-end production approach, meaning the linking of continuous synthesis of API from intermediates with the production of final dosage form, are described.
Results: There are a growing number of scientific articles showing an increasing interest in changing the approach to the production of pharmaceuticals in recent years. Numerous scientific publications are a source of information on the progress of knowledge and achievements of continuous processing. These works often deal with issues of how to modify or replace the unit processes in order to enable seamlessly switching them into continuous processing. A growing number of research papers concentrate on integrated continuous manufacturing lines in which the production concept of “from powder to tablet” is realized. Four main domains are under investigation: influence of process parameters on intermediates or final dosage forms properties, implementation of process analytical tools, control-managing system responsible for keeping continuous materials flow through the whole manufacturing process and the development of new computational methods to assess or simulate these new manufacturing techniques. The attempt to connect the primary and secondary production steps proves that development of continuously operating lines is possible.
Conclusion: A mind-set change is needed to be able to face, and fully assess, the advantages and disadvantages of switching from batch to continuous mode production. 相似文献