ERP人力资源管理系统在油气企业的应用

基于信息技术的人力资源管理系统是提高企业管理水平和推动人事管理创新的战略工具。阐述了ERP人力资源管理系统应用的4个层次及其主要特征,从系统的功能和结构、作用和规则以及数据质量几方面分析了中国石油ERP人力资源管理系统的运行机理。     

2种600℃超临界锅炉用奥氏体钢的高温氧化行为

采用热重法研究了Super304H和HR3C两种奥氏体耐热钢于750℃静态空气中的循环氧化行为。结果表明,Super304H由于氧化膜的大量剥落很快出现失重,其质量随循环周次的增加而线性减小。在循环氧化条件下,Super304H表面形成由外层FeCr_2O_4和内层(Cr,Mn)_2O_3组成的双层氧化膜,2层膜的层间形成大量的空洞,导致FeCr_2O_4在冷却时压应力作用下剥离并进一步剥落。相反地,HR3C的氧化增重遵循抛物线规律,而在300个循环周次后增重呈线性加速的趋势。氧化增重加速的原因在于:HR3C表面形成单层(Cr,Mn)_2O_3膜,膜局部与基体分离并拱起,拱起的氧化膜在冷却过程中开裂,导致膜下方的基体在后续的氧化过程中直接暴露于高温空气并与之发生化学反应形成新鲜的富Cr氧化物。     

HR3C焊接接头700℃长期时效后的组织与性能分析

对HR3C钢焊接接头在700℃长期时效后进行了力学性能、系列冲击试验,采用光学显微镜对焊缝的显微组织进行了观察与分析。结果表明,HR3C焊接接头在700℃长期时效后拉伸性能良好,但晶界和晶内均有化合物析出,弯曲试样已发生脆断。     

高阻硅基铝硅合金弹性膜MEMS相移器

级联式MEMS相移器可通过悬浮于共平面波导之上的微机械可调电容的变化,来改变传输线的特性阻抗和相速,达到相移的目的.文中讨论了MEMS相移器特性对微机械电容和下拉电压的要求,并通过轻质量的铝硅合金弹性膜,获得了较低的下拉电压.测试结果表明,相移器的下拉电压不大于40V,且当控制电压大于10V时,即有明显的相移.该MEMS相移器制备于电阻率大于4000Ω*cm的高阻硅衬底上,获得了较好的传输特性,在整个测试频段1～40GHz,S21均小于3dB,并在25V时获得了大于25°的相移量.     

The Finely Coordinated Action of SSB and NurA/HerA Complex Strictly Regulates the DNA End Resection Process in Saccharolobus solfataricus

Generation of the 3′ overhang is a critical step during homologous recombination (HR) and replication fork rescue processes. This event is usually performed by a series of DNA nucleases and/or helicases. The nuclease NurA and the ATPase HerA, together with the highly conserved MRE11/RAD50 proteins, play an important role in generating 3′ single-stranded DNA during archaeal HR. Little is known, however, about HerA-NurA function and activation of this fundamental and complicated DNA repair process. Herein, we analyze the functional relationship among NurA, HerA and the single-strand binding protein SSB from Saccharolubus solfataricus. We demonstrate that SSB clearly inhibits NurA endonuclease activity and its exonuclease activities also when in combination with HerA. Moreover, we show that SSB binding to DNA is greatly stimulated by the presence of either NurA or NurA/HerA. In addition, if on the one hand NurA binding is not influenced, on the other hand, HerA binding is reduced when SSB is present in the reaction. In accordance with what has been observed, we have shown that HerA helicase activity is not stimulated by SSB. These data suggest that, in archaea, the DNA end resection process is governed by the strictly combined action of NurA, HerA and SSB.     

高性能193nm反射膜的制备与误差分析

分析了膜厚控制误差对反射膜设计曲线的影响,发现高低折射率材料厚度反方向变化时(高折射率膜层厚度增加,低折射率膜层厚度减小),反射膜的反射率变化不明显,设计的膜系结构对这种膜厚变化方式的制造误差宽容.在此基础上制备了193nm反射膜,结果表明退火前光学损耗相对较大,实验结果与理论计算结果存在一定差距,并且散射损耗在总的光学损耗中所占比例很小,而吸收损耗占光学损耗的主要部分,起主导作用.退火后光学损耗明显下降,实验结果与理论计算结果更为接近,193nm反射膜的反射率达98%以上.散射损耗增加至接近吸收损耗的水平,不过在总的光学损耗中仍然占比较小的比例.说明当吸收损耗下降到一定程度时,散射损耗所起的作用也是不可忽视的.     

HR3C在超临界水中的腐蚀性能研究

通过高压釜浸泡实验研究了超级奥氏体不锈钢HR3C在循环的超临界水（SCW）中的均匀腐蚀性能,实验温度分别为550、600、650 ℃,压力为25 MPa,并对实验后试样生成的氧化膜进行了SEM、EDS和XRD分析。实验结果显示,HR3C在SCW环境中的氧化腐蚀速率随着温度的升高而增大,1 500 h后650 ℃ SCW环境下材料的腐蚀增重约为550 ℃时的2倍。材料表面生成的氧化膜主要成分为FeCr₂O₃、Fe₃O₄和Fe₂O₃,内层氧化膜富Cr而外层氧化膜富Fe。     

H814-902/不饱和聚酯树脂/淤泥体系收缩研究

在淤泥填充不饱和聚酯树脂的新体系中加入低收缩添加剂H814-902控制固化收缩。通过体积收缩率计算,研究不饱和聚酯树脂/淤泥体系、不饱和聚酯树脂/淤泥/低收缩添加剂体系收缩性能和抗弯强度。研究结果表明:当低收缩添加剂、不饱和聚酯树脂、淤泥之间的质量比为18∶100∶100时,其体系收缩率达到将其用于低收缩片状模塑料的要求;当玻璃纤维的质量分数为30%时,其抗弯强度达到低收缩片状模塑料强度100 MPa的要求。研究中首次尝试采用高分辨魔角旋转核磁共振(HR/MAS-NMR)方法,并结合SEM方法分析不饱和聚酯树脂/淤泥/低收缩添加剂体系抗收缩机理,提出该体系中空穴、两相岛屿状结构以及固化反应中交联度的下降是抑制体系收缩的主要原因。     

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination

PTEN has been implicated in the repair of DNA double-strand breaks (DSBs), particularly through homologous recombination (HR). However, other data fail to demonstrate a direct role of PTEN in DSB repair. Therefore, here, we report experiments designed to further investigate the role of PTEN in DSB repair. We emphasize the consequences of PTEN loss in the engagement of the four DSB repair pathways—classical non-homologous end-joining (c-NHEJ), HR, alternative end-joining (alt-EJ) and single strand annealing (SSA)—and analyze the resulting dynamic changes in their utilization. We quantitate the effect of PTEN knockdown on cell radiosensitivity to killing, as well as checkpoint responses in normal and tumor cell lines. We find that disruption of PTEN sensitizes cells to ionizing radiation (IR). This radiosensitization is associated with a reduction in RAD51 expression that compromises HR and causes a marked increase in SSA engagement, an error-prone DSB repair pathway, while alt-EJ and c-NHEJ remain unchanged after PTEN knockdown. The G₂-checkpoint is partially suppressed after PTEN knockdown, corroborating the associated HR suppression. Notably, PTEN deficiency radiosensitizes cells to PARP inhibitors, Olaparib and BMN673. The results show the crucial role of PTEN in DSB repair and show a molecular link between PTEN and HR through the regulation of RAD51 expression. The expected benefit from combination treatment with Olaparib or BMN673 and IR shows that PTEN status may also be useful for patient stratification in clinical treatment protocols combining IR with PARP inhibitors.