高压带电体温度检测装置

针对传统高压带电体测温方法存在的难以实现电气绝缘、精度低等问题,介绍了一种新型高压带电体温度检测装置的设计方案。该装置采用传统接触式测温方式下的温度传感器采集温度信号,采用可调电流源+感生电源方式实现供电,各感生电源与可调电流源通过高压线连接,不同测温点的感生电源之间没有电气连接,且采用光纤传输温度信号,从而很好地实现了电气绝缘。实验结果表明,该装置的感生电源电压稳定,测温精度高,抗干扰能力强。     

The importance of the compression test procedure for plastic drums for dangerous goods

Packagings for the transport of dangerous goods are tested by four tests:- free fall, leakproofness, hydraulic pressure and stacking. However, the test procedures can be interpreted in different ways, particularly the stacking test. Some test authorities apply a guided load to the top of the package and others, including the LNE in France, use non-guided loads. The objective of recent research carried out at LNE was to evaluate the risk (in terms of stack stability for dangerous goods packagings) if the stacking tests are performed with guided loads rather than non-guided loads. The stacking tests were carried out on a limited number of plastic drums (200 of four types) submitted for qualification testing using the above four tests, with either guided or non-guided loads. From the results we conclude that:

• i for the transport of dangerous goods of Danger Group I, the field of use is not altered when tested by either procedure.
• ii with goods of Danger Groups II and III, the use of either procedure does not alter the position as far as transport is concerned. However, there is a risk in warehousing: the non-guided procedure being preferred.

     

Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(−413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility. We found that the short alleles are significantly more frequent in ALL patients in comparison to the control group, and that their presence may be associated with a higher risk of treatment failure, reflecting the role of HO-1 in chemoresistance. We also observed that the presence of short alleles may predispose to develop chemotherapy-induced neutropenia. In case of SNP, the 413-T variant co-segregated with short or long alleles, while 413-A almost selectively co-segregated with long alleles, hence it is not possible to determine if SNPs are actually of phenotypic significance. Our results suggest that HO-1 can be a potential target to overcome the treatment failure in ALL patients.     

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells. Primary MSCs can be obtained from diverse sources, including bone marrow, adipose tissue, and umbilical cord blood. Recently, MSCs have been recognized as therapeutic agents for skin regeneration and rejuvenation. The skin can be damaged by wounds, caused by cutting or breaking of the tissue, and burns. Moreover, skin aging is a process that occurs naturally but can be worsened by environmental pollution, exposure to ultraviolet radiation, alcohol consumption, tobacco use, and undernourishment. MSCs have healing capacities that can be applied in damaged and aged skin. In skin regeneration, MSCs increase cell proliferation and neovascularization, and decrease inflammation in skin injury lesions. In skin rejuvenation, MSCs lead to production of collagen and elastic fibers, inhibition of metalloproteinase activation, and promote protection from ultraviolet radiation-induced senescence. In this review, we focus on how MSCs and MSC-derived molecules improve diseased and aged skin. Additionally, we emphasize that induced pluripotent stem cell (iPSC)-derived MSCs are potentially advanced MSCs, which are suitable for cell therapy.     

iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements,Challenges and Future Perspectives

Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect cardiac ion channels or their accessory proteins. The main hurdle for the study of the functional effects of those variants is the need for a specific model that mimics the complex environment of human cardiomyocytes. Traditionally, animal models or transient heterologous expression systems are applied for electrophysiological investigations, each of these models having their limitations. The ability to create induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), providing a source of human patient-specific cells, offers new opportunities in the field of cardiac disease modelling. Contemporary iPSC-CMs constitute the best possible in vitro model to study complex cardiac arrhythmia syndromes such as BrS. To date, thirteen reports on iPSC-CM models for BrS have been published and with this review we provide an overview of the current findings, with a focus on the electrophysiological parameters. We also discuss the methods that are used for cell derivation and data acquisition. In the end, we critically evaluate the knowledge gained by the use of these iPSC-CM models and discuss challenges and future perspectives for iPSC-CMs in the study of BrS and other arrhythmias.     

基于AIE特性的萘酰亚胺衍生物的合成及光谱研究

以分子内电荷转移为原理,选用萘酰亚胺为荧光团,与三苯胺通过偶联反应,制备了一种萘酰亚胺衍生物有机光功能小分子材料,其合成路线简单,实验操作条件易控,成品产率较高。对其光学性能进行研究,在不同溶剂中的光学性能主要表现出两个强吸收带,荧光发射达到到近红外区域,其表现出了非常明显的聚集诱导发光（AIE）特性,固体表现出很强的橘橙色荧光现象。     

10kV运行配电线路雷电感应过电压波形在线监测

雷电感应过电压是造成配电网故障的重要原因之一,针对雷电感应过电压波形特征不清晰的问题,作者采用过电压在线监测系统,对实际运行的佛山10kV富油甲线雷电感应过电压波形进行观测,根据波形特征给出了过电压的波形参数。结果表明,配电线路各相感应电压叠加在运行电压波形上,不同相上感应过电压与对应的回击电流在幅度、时间间隔和波形上都存在同时性,该线路观测的雷电感应电压波形表现为波头时间短、后续发生双极性高频振荡并逐渐转变为低频振荡的波形特点,首次回击感应过电压幅值大于后续回击过电压幅值,首次回击过电压的波头时间比后续过电压长,观测结果对于配电线路雷电保护具有重要意义。     

Selective oxidation of Fe-30Ni alloy in a low-temperature range (433–473 K)

Fe-30Ni alloy specimens were oxidized for 10–240 min at 433–473 K in pure oxygen at a pressure of 1.33×10⁴ Pa. The thickness of oxide films was measured by a multiple-angle-of-incidence ellipsometer. The kinetics of film growth were found to obey a parabolic rate law. The depth-profiling of oxidized surfaces, performed with simultaneous use of Auger electron spectroscopy (AES) and argon-ion sputter-etching technique, reveals that iron component is selectively oxidized and an iron-depeletion zone is formed in the underlying alloy. The thickness of the iron depletion zone increases with increasing oxidation time or oxidation temperature. During surface oxidation of the alloy, the transport rate of iron component in the film is almost equal to the interdiffusion rate in the underlying alloy, indicating the establishment of a steady state. The values of the interdiffusion coefficient, , of the underlying alloy estimated from the depth-composition profiles are more than 10 orders of magnitude as large as the values extrapolated from the lattice diffusion data of the corresponding alloy obtained at high temperature. The enormously large values of may be explained in terms of the vacancy (monovacancy or divacancy)-enhanced lattice diffusion mechanism.     

管线用钢氢致裂纹(HIC)影响因素分析

研究了管线用钢的化学成分和金相组织对钢的氢致裂纹(HIC)性能的影响。研究认为,带状组织和马氏体含量对HIC性能有很大影响,S含量及Cep对HIC有不同程度影响。含有少量Cu、Ni的钢更适合在酸性环境下使用。     

接触疲劳过程中的诱发相变和冷作硬化SCIEI

研究了三种丝杠钢的接触疲劳性能。利用TEM和背散射Mossbauer谱研究了三种钢在接触疲劳前后的显微组织结构;测量了接触区中心线下显微硬度随层深的变化。结果表明:接触应力诱发A_R→M相变,并导致一定深度的冷作硬化。讨论了诱发相变和冷作硬化对接触疲劳性能的影响。