On‐Demand Wrinkling Patterns in Thin Metal Films Generated from Self‐Assembling Liquid Crystals

In this work, a new, universal method is described that uses the photopatterning of liquid crystals, which is accurately translated into a controlled, intricately wrinkled metal surface. Remarkably, the patterns have an oscillation in amplitude of the wrinkles. This rapid method allows generation of intricate multidomain patterns and continuous circular structures, including azimuthal, radial, and even higher complexity arrangements as examples. These wrinkled gold surfaces are also strikingly visual, which is interesting for applications ranging from diffractive elements to fine jewelry.     

Single Molecule with Dual Function on Nanogold: Biofunctionalized Construct for In Vivo Photoacoustic Imaging and SERS Biosensing

Multimodal imaging provides complimentary information that is advantageous in studying both cellular and molecular mechanisms in vivo, which has tremendous potential in pre‐clinical research and clinical translational imaging. It is desirable to design probes for multimodal imaging that can be administered minimally but provides multifaceted information. Herein, we demonstrate the complementary dual functional ability of a nanoconstruct for molecular imaging in both photoacoustic (PA) and surface‐enhanced Raman scattering (SERS) biosensing simultaneously in tandem. To realize this, a group of NIR active organic molecules are designed and synthesized that possess both SERS and PA activity. Nanoconstructs realized by anchoring such molecules onto gold nanoparticles are demonstrated for targeting cancer biomarkers in vivo while providing complimentary information about biodistribution and targeting efficiency. In future, such nanoconstructs could play a major role in identifying surgical margins and also for disease monitoring in translational medicine.     

不对称金纳米结构的光致热增强效应的调控研究

提出了一种产生光致热增强效应的不对称的人工金 纳米结构,建立了物理模型并进行了计算。采用离散偶极近似(DDA)方法计算水介质环境中 该结构及其不对称性改变后对吸收光谱及近区电磁场分布的影响,进而 利用傅里叶热传导定律数值模拟了该结构产生的热增强效应。结果表明:改变纳米结构的不 对称程度会明显影响结 构的光谱吸收位置、线型和峰值强度;同时,通过调节纳米结构的不对称性也可以有效地将 磁场能转化为热能,并 在结构周围形成高度限定的局域热增强现象。本文提出的纳米结构可在较大的近红外波段范 围内调控温度,可作为纳米尺度 下精确控制光致热效应的温度和设计热等离子纳米器件之参考。     

Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

In this paper, a simple, but effective method is reported to construct the core?shell gold nanorod@metal–organic frameworks (AuNR@MOFs) as a multifunctional theranostic platform by using functionalized AuNRs as seed crystal for the growth of porphyrinic MOFs on the surface of AuNR. Such a delicate tunable core?shell composite not only possesses the improved drug loading efficiency, near‐infrared light‐trigger drug release, and fluorescence imaging, but also can produce reactive oxygen species as well as photothermal activity to achieve combined cancer therapy. It is further demonstrated that the camptothecin loaded AuNR@MOFs show distinctively synergistic efficiency for damaging the cancer cell in vitro and inhibiting the tumor growth and metastasis in vivo. The development of this high‐performance incorporated nanostructure will provide more perspectives in the design of versatile nanomaterials for biomedical applications.     

人精子甘露糖受体的胶体金标记电镜观察

本文首次报道人精子甘露糖受体（ＭＲ）的电镜标记技术和初步观察了，采用甘露糖化牛血清白蛋白（ＤＭＡ，Ｓｉｇｍａ，Ａ８３０３）结合１０ｎｍ胶体金制备探针，标记获能前后精子和甲醇处理或Ａ２３１８７诱导顶体反应（ＡＲ）的精子。结果表明，甲醇处理后ＭＲ表达顶体区质膜表面，活精子在ＡＲ过程中以不同方式表达ＭＲ活性；ＭＲ定位于：１．ＡＲ早期的精子顶体区质膜表面。２．ＡＲ期间精子的顶体小泡表面，顶体内膜及顶体基质     

对凡口矿深部开采顺序的探讨

通过对凡口矿的矿床赋存规律 ,影响深部开拓的几个技术问题和目前的生产现状等的分析 ,提出上部、深部同时开采 ,上部由上至下、深部由下至上的开采顺序 ,可使该矿今后的生产经营更加灵活。     

内蒙古新城子火山盆地遥感解译及铀成矿预测

内蒙古新城子火山盆地位于大兴安岭南端及扎兰屯火山岩型铀成矿远景带南端,盆地内中生代火山活动频繁且强烈,主要发育火山岩型铀矿。笔者利用Landsat ETM及高分一号遥感数据,对研究区进行了系统构造解译及蚀变信息提取,结合已有地质资料,初步确定了研究区以NE、NW、近EW、近NS向4组线性构造为构造格架。最终根据构造、铀矿化、遥感蚀变等信息圈定3处找矿远景区,期望为该区下一步铀矿地质找矿工作提供依据。     

无水有机溶剂-氯化铜体系浸出金的研究

以单因素实验及正交实验研究了无水CuCl2-N,N-二甲基甲酰胺体系浸出金。在无水CuCl2浓度0.75 mol/L、浸出温度75℃、浸出时间75 min、液固比500：1的优化条件下,金的浸出率可以达到96.6%;浸出液中的金可被蒸馏水还原,得到金单质,常温下加溶液体积80%的蒸馏水,经1.5 h,金的还原率达99.2%。体系对实际物料表现出很好的恒择性浸出金的能力。     

微细粒浸染型金矿氧化矿提金扩大试验

介绍了某微细粒浸染型金矿氧化矿炭浆法提金扩大试验结果。在试验规模 547.72 kg/ d下 ,经 72 h连续运转 ,金浸出率达到 96.76% ,金吸附率达到 99.2 1 %。     

某原生金矿矿石可选性试验

本文主要对某原生金矿的矿石可浮性进行了研究。通过 Lq(34)正交试验选择了粗选的最佳操作条件 :磨矿细度 - 2 0 0目 75% ;Na2 Si O3 用量 750 g/ t;Cu SO4用量 2 0 0 g/ t;乙黄药用量53g/ t。在此条件下 ,采用一粗二精二扫流程进行了实验室闭路试验 ,获得了精矿品位 79.61 g/ t、回收率 91 .30 %的金精矿 ,表明该矿可以通过浮选达到富集的目的。