Formation of Benzo(a)pyrene in Sesame Seeds During the Roasting Process for Production of Sesame Seed Oil

The main aim of this research was to enhance the understanding of the formation mechanisms of benzo(a)pyrene (BaP) during roasting of sesame seeds (SS). BaP levels in hot‐ and cold‐pressed sesame seed oil (SSO) were evaluated to correlate oil technology and BaP formation. Extracted principal components from SS were roasted either singly or in mixtures at 230 °C for 30 min. BaP was measured by HPLC with fluorescence detection. The results showed that BaP levels in hot‐pressed SSO were significantly higher than those in cold‐pressed SSO (p < 0.05), BaP formation mostly occurred during SS roasting and increased with roasting temperature (between 80 and 280 °C) and time (from 10 to 50 min). Furthermore, the BaP level in the roasted hulled SS (3.64 μg/kg) was higher than it was in roasted whole SS (1.63 μg/kg). The maximum BaP level observed (5.03 μg/kg) was detected in a roasted mixture of SS protein and SSO. The addition of sesame protein to protein‐free SSO promoted the formation of BaP, which suggests that the pyrolysis products of protein and triacylglycerols are probably important precursors in BaP formation.     

Potent,Metabolically Stable 2‐Alkyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐adenines as Adenosine A2A Receptor Ligands

Inhibition of adenosine A_2A receptors has been shown to elicit a therapeutic response in preclinical animal models of Parkinson’s disease (PD). We previously identified the triazolo‐9H‐purine, ST1535, as a potent A_2AR antagonist. Studies revealed that ST1535 is extensively hydroxylated at the ω‐1 position of the butyl side chain. Here, we describe the synthesis and evaluation of derivatives in which the ω‐1 position has been substituted (F, Me, OH) in order to block metabolism. The stability of the compounds was evaluated in human liver microsomes (HLM), and the affinity for A_2AR was determined. Two compounds, (2‐(3,3‐dimethylbutyl)‐9‐methyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐purin‐6‐amine ( 3 b ) and 4‐(6‐amino‐9‐methyl‐8‐(2H‐1,2,3‐triazol‐2‐yl)‐9H‐purin‐2‐yl)‐2‐methylbutan‐2‐ol ( 3 c ), exhibited good affinity against A_2AR (K_i=0.4 nM and 2 nM , respectively) and high in vitro metabolic stability (89.5 % and 95.3 % recovery, respectively, after incubation with HLM for two hours).     

硫化罐封头法兰刚度的有限元分析

根据ASME标准,法兰刚度变化可由法兰转角反映。对某硫化罐进行分析,利用ANSYS有限元软件进行有限元计算,对封头法兰端面定义路径并由路径上点位移换算成路径转角。通过改变尺寸参数,最终得到封头法兰端面不同位置刚度变化规律并指出硫化罐端盖部分易发生泄漏位置。     

略论平面角之正投影

一般情况下,平面角之正投影都发生变形(变大或变小).本文论述了在不同倾角;夹角两边处于不同位置时,平面角发生变化情况.     

圆度误差的评定和计算机处理

本文介绍按最小区域法评定圆度误差以及用PB-700计算机数据处理的原理和方法。     

EBZ260综掘机加快岩巷掘进研究

为加快佳瑞矿岩巷掘进进度,通过分析EBZ260综掘机主要技术参数、配套装备、操作注意事项,经过安装调试到投入使用,综掘机达到月平均进尺150 m,年累计进尺1 650m以上,加快了岩巷快速掘进,进一步解决了高瓦斯矿井掘进问题。     

煤化工大跃进下的绿色变身猜想

分析了煤化工(煤制油)和风电产业面临的问题,提出了转换角度看待煤化工发展中的制约,把二氧化碳捕集、风电制氢和逆水煤气变换反应相结合,提出煤化工绿色变身的发展思路。     

钢水的流动与夹杂物分离上浮的研究——水平连铸中间包水模试验研究之二

通过四因素三水平的正交设计法进行了27次水模试验。经方差分析,吹气与不吹气因素对颗粒的上浮率有显著影响。中间包熔池经吹气后,可改善停留时间分布,使中间包流场更趋合理,从而提高了颗粒的上浮率。     

液氯钢瓶凹坑应力研究

通过液氯钢瓶凹坑应力测试,给出不同参数的凹坑应力分布,为液氯钢瓶判废标准提供依据.     

企业内部控制与往来账款的管理

通过分析企业应收账款存在的问题，说明加强企业往来账款内部控制的重要性。