Site-Specific PEGylation of Therapeutic Proteins

The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant problems still remain with their use. Among these problems are rapid degradation and excretion from patients, thus requiring frequent dosing, which in turn increases the chances for an immunological response as well as increasing the cost of therapy. One of the main strategies to alleviate these problems is to link a polyethylene glycol (PEG) group to the protein of interest. This process, called PEGylation, has grown dramatically in recent years resulting in several approved drugs. Installing a single PEG chain at a defined site in a protein is challenging. Recently, there is has been considerable research into various methods for the site-specific PEGylation of proteins. This review seeks to summarize that work and provide background and context for how site-specific PEGylation is performed. After introducing the topic of site-specific PEGylation, recent developments using chemical methods are described. That is followed by a more extensive discussion of bioorthogonal reactions and enzymatic labeling.     

Factors involved in associations between Facebook use and college adjustment: Social competence,perceived usefulness,and use patterns

Although previous research has investigated widespread use of social media, especially Facebook, by youth attending college, the conditions under which these media foster adjustment to college remain unclear. This study tested a model illuminating pathways linking social competence to college adjustment via students’ perceptions about the usefulness of Facebook and ways in which they used the medium. Self-report survey data from 321 college students (M age = 20.09; 58% female; 84% Caucasian) attending a major Midwestern university supported the proposed model, indicating that higher social competence could foster or impede college adjustment, depending upon how it was related to beliefs about the usefulness of different Facebook functions and how these perceptions, in turn, were associated with patterns of Facebook use. Findings underscore the importance of considering connections among personal attributes, perception of media effectiveness, and media behaviors in assessing the implications of social media for users’ psychosocial well-being.     

现场总线在冶炼烟气制酸系统中的应用实践

分析了冶炼烟气制酸工艺的特点，介绍了由PROFIBUS-DP现场总线构建的冶炼厂烟气制酸监控系统，详细介绍了其硬件配置及相应的软件设计。     

Effects of Rare Earths on Toughness of 31Mn2SiRE Wear-Resistance Cast Steel

The toughness of 31Mn2SiRE wear-resistance cast steel were increased by means of RE compound modification and high temperature austenitizing. The results show that the microstructures can be refined, needle and network ferrite are eliminated, the dislocation density and the quantity of dislocated martensite are increased remarkably, and the shape and distribution of inclusions are improved by the addition of RE. Therefore, the mechanical properties of the modified steel can be greatly increased, especially the toughness (αK) by 44%, yield strength (σs) by 10%, and elongation (δ5) by 42%.     

Characterization of Austempered Ductile Iron Through Barkhausen Noise Measurements

The outstanding mechanical properties of austempered ductile irons (ADI) are linked to the microstructure of the matrix obtained by subjecting a ductile iron with an appropriate composition to a heat treatment called austempering. Then the microstructure of the matrix consists of bainitic ferrite with different volume fractions of retained austenite. The aim of this work is to use the magnetic Barkhausen noise (MBN) as a nondestructive method for characterizing the microstructure of ADI. First, it is shown that the amplitude and position of the peak-shaped MBN response is quite sensitive to the microstructure of the matrix of ductile irons. Thus each type of constituent (equiaxial ferrite, pearlite, martensite or bainite) exhibits a typical response and, in turn, it can be identified from the MBN response. Furthermore, a good correlation is found between MBN signal parameters and ADI heat treatment parameters, indicating that MBN is also quite sensitive to fine evolutions of the microstructure of ADI. MBN peak position is especially sensitive to the type of bainite, whereas peak amplitude is linked to the progress of the bainite reaction. Hence MBN measurements appear to be a powerful tool to assess some important microstructural features of ADI castings.     

Damage Development in Gray Cast Iron under Static Deformation

The authors discuss the results of experimental investigation of structural degradation of gray cast iron at various stages of static tensile deformation. Analysis of the deformation process has revealed that damageability of a material under loading can be assessed by both a special strain parameter and scatter of hardness characteristics or a ratio of the modulus deviation to the current value of the elastic modulus. A correlation between these parameters has been established.     

激光冶炼太阳级硅材料的实验研究

通过实验研究表明，大功率ＣＯ２激光器在廉价硅材料制备中应用的可能性。     

废钢铁代用品

优质钢材的冶炼和高水平操作指标的获得需要优良的原料作保证。直接还原铁，碳化铁和脱碳粒铁作为废钢铁代用品，已显示出其价格和品质上的优越性，并弥补了废铁数量的不足，但因其各有自身的特点，故研究其理化性质和使用性能，将为大规模生产和使用创造必要的条件。     

喷射轧制Fe-4.5%Si硅钢片的组织和性能

采用喷射成形和轧制工艺制备了厚度为0.5mm的Fe-4.5%Si高硅钢片，并对其密度、显微组织和电磁性能进行了测试分析，研究结果表明：在最佳的喷射成形和轧制工艺条件下，所制备硅钢片的磁感应强度B25为1.544T、B50为1.641T；铁损P1050为1.437W/kg、P1550为3.43W/kg，说明喷射成形轧制技术可以制备出高磁感应强度、低铁损的高硅钢片。