Depression among Latinos in the United States: A meta-analytic review.

The authors conducted a meta-analytic review to assess the prevalence of major depressive disorder and depressive symptoms among Latinos compared with non-Latino Whites in the United States using community-based data. Random-effects estimates were calculated for 8 studies meeting inclusion criteria that reported lifetime prevalence of major depressive disorder (combined N = 76,270) and for 23 studies meeting inclusion criteria that reported current prevalence of depressive symptoms (combined N = 38,997). Findings did not indicate a group difference in lifetime prevalence of major depressive disorder (odds ratio = 0.89, 95% confidence interval = 0.72, 1.10). Latinos reported more depressive symptoms than non-Latino Whites (standardized mean difference = 0.19, 95% confidence interval = 0.12, 0.25); however, this effect was small and does not appear to suggest a clinically meaningful preponderance of depressive symptoms among Latinos. Findings are examined in the context of theories on vulnerability and resilience, and recommendations for future research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychotherapy for depression in adults: A meta-analysis of comparative outcome studies.

Although the subject has been debated and examined for more than 3 decades, it is still not clear whether all psychotherapies are equally efficacious. The authors conducted 7 meta-analyses (with a total of 53 studies) in which 7 major types of psychological treatment for mild to moderate adult depression (cognitive-behavior therapy, nondirective supportive treatment, behavioral activation treatment, psychodynamic treatment, problem-solving therapy, interpersonal psychotherapy, and social skills training) were directly compared with other psychological treatments. Each major type of treatment had been examined in at least 5 randomized comparative trials. There was no indication that 1 of the treatments was more or less efficacious, with the exception of interpersonal psychotherapy (which was somewhat more efficacious; d = 0.20) and nondirective supportive treatment (which was somewhat less efficacious than the other treatments; d = -0.13). The drop-out rate was significantly higher in cognitive-behavior therapy than in the other therapies, whereas it was significantly lower in problem-solving therapy. This study suggests that there are no large differences in efficacy between the major psychotherapies for mild to moderate depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rational emotive behavior therapy versus cognitive therapy versus pharmacotherapy in the treatment of major depressive disorder: Mechanisms of change analysis.

Cognitive-behavioral psychotherapies (CBT) are among the first-line interventions for major depressive disorder (MDD), and a significant number of studies indicate their efficacy in the treatment of this disorder. However, differential effects of various forms of CBT have seldom been analyzed in the same experimental design. On the basis of data collected in a randomized clinical trial comparing the efficacy of rational-emotive behavior therapy (REBT), cognitive therapy (CT), and pharmacotherapy (SSRI) in the treatment of MDD, the present article investigates the theory of change advanced by REBT and CT. Measures included to test the two theories of change assess three classes of cognitions: (a) automatic thoughts, (b) dysfunctional attitudes, and (c) irrational beliefs. The results indicate that REBT and CT (and also pharmacotherapy) indiscriminately affect the three classes of cognitions. On the long term (follow-up), a change in implicit demandingness seems more strongly associated with reduced depression and relapse prevention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Epigenetic Modifications of Major Depressive Disorder

Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders.     

Relations entre humeur dépressive et somatisation: Recension des écrits autour du portrait cible du somatisateur.

A diagnosis of clinical depression just as masked depression is often associated with body aches that can not be medically explained. After a presentation of operational definitions of somatization and psychosomatic disorders, and of the relationship between depression and somatization, a sociopsychological portrait is given of a target subject suffering from somatization disorder, as discussed in recent publications. The type and psychosocial characteristics, vulnerability to stress, character traits and beliefs, and the family model of the average person suffering from somatization disorder were specified. Finally, the relevance of various treatments was discussed, emphasizing the interest in multiple treatments after arriving at a successful diagnosis. The clinical benefits of prevention in the normal person and of learning to control the psyche/soma interrelationship were outlined. Developing research on somatization, whether it is related or not to depressive moods, is definitely of cultural and financial interest since these patients are large consumers of health care. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Symptoms of Depression in Older Home-Care Patients: Patient and Informant Reports.

The purpose of this study was to examine the level of agreement and patterns of disagreement between home-care patient and informant reports of depressive symptoms. The authors interviewed a sample of 355 older home-care patients and their informants using the Structured Diagnostic Interview for DSM-IV (R. L. Spitzer, M. Gibbon, & J. B. Williams, 1995). Informants reported more psychological symptoms than patients, and this type of discrepancy was higher for patients with cognitive impairment and patients who had younger informants. Younger informants also reported more cognitive symptoms, whereas patients were more likely to report suicidal thoughts or ideation if they were not cognitively impaired. The patterns of these discrepancies may reflect age- and cohort-related response bias in the reports of depressive symptoms obtained from older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Optimism and Pessimism as Mediators of the Relations Between Self-Discrepancies and Distress Among Asian and European Americans.

The authors examined the role of undesired self-discrepancies in predicting emotional distress among Asian and European Americans, whether undesired self-discrepancies are stronger predictors of distress for Asian than for European Americans, and whether optimism and pessimism mediate the relations between ideal, ought, and undesired self-discrepancies and emotional distress. Self-identified Asian/Asian American (n = 140) and European American (n = 189) college students completed measures of self-discrepancies, optimism/pessimism, social anxiety, and depressive symptoms. Results show that for both Asian Americans and European Americans, greater similarity to the undesired self is equally predictive of symptoms of depression, whereas distance from the undesired self is more predictive of social anxiety for Asian Americans than for European Americans. Furthermore, pessimism fully mediates the relations between undesired self-discrepancies and depressive symptoms for both Asian Americans and European Americans, although pessimism was a stronger predictor of depression for European Americans than for Asians/Asian Americans. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Methylphenidate Ameliorates Depressive Comorbidity in ADHD Children without any Modification on Differences in Serum Melatonin Concentration between ADHD Subtypes

The vast majority of Attention-deficit/hyperactivity disorder (ADHD) patients have other associated pathologies, with depressive symptoms as one of the most prevalent. Among the mediators that may participate in ADHD, melatonin is thought to regulate circadian rhythms, neurological function and stress response. To determine (1) the serum baseline daily variations and nocturnal excretion of melatonin in ADHD subtypes and (2) the effect of chronic administration of methylphenidate, as well as the effects on symptomatology, 136 children with ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision: DSM-IV-TR criteria) were divided into subgroups using the “Children’s Depression Inventory” (CDI). Blood samples were drawn at 20:00 and 09:00 h, and urine was collected between 21:00 and 09:00 h, at inclusion and after 4.61 ± 2.29 months of treatment. Melatonin and its urine metabolite were measured by radioimmunoassay RIA. Factorial analysis was performed using STATA 12.0. Melatonin was higher predominantly in hyperactive-impulsive/conduct disordered children (PHI/CD) of the ADHD subtype, without the influence of comorbid depressive symptoms. Methylphenidate ameliorated this comorbidity without induction of any changes in the serum melatonin profile, but treatment with it was associated with a decrease in 6-s-melatonin excretion in both ADHD subtypes. Conclusions: In untreated children, partial homeostatic restoration of disrupted neuroendocrine equilibrium most likely led to an increased serum melatonin in PHI/CD children. A differential cerebral melatonin metabolization after methylphenidate may underlie some of the clinical benefit.     

Hopelessness as a mediator of the association between social support and depressive symptoms: Findings of a study of men with HIV.

Data from a prospective longitudinal study were used to investigate whether hopelessness mediates the association between social support and depression, as hypothesized by L. Y. Abramson, G. I. Metalsky, and L. B. Alloy (1989). Measures of hopelessness, social support, and depression were administered to 103 HIV-infected men and readministered 6 months later. Findings indicated that low baseline social support predicted increases in hopelessness and depression. Increases in hopelessness predicted increases in depression after controlling for baseline social support. Low baseline social support did not predict increased depression when hopelessness was controlled statistically. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adult Attachment, Depressive Symptoms, and Validation From Self Versus Others.

Attachment working models of self and others may govern adults' preferences for internal vs. external sources of reassurance, which, if unavailable, lead to depressive symptoms. This study examined a model in which the link between depressive symptoms and attachment anxiety is mediated by (a) capacity for self-reinforcement and (b) need for reassurance from others, whereas the link between depressive symptoms and attachment avoidance is mediated only by the capacity for self-reinforcement. Analysis of survey data from 425 undergraduates indicated that both capacity for self-reinforcement and need for reassurance from others partially mediated the link between attachment anxiety and depression. Capacity for self-reinforcement fully mediated the link between attachment avoidance and depression. Moreover, 54% of the variance in depressive symptoms was explained by attachment anxiety, self-reinforcement, and need for reassurance from others. (PsycINFO Database Record (c) 2010 APA, all rights reserved)