海藻酸钠纳米粒制备的研究进展

纳米粒药物载体能帮助药物靶向传输及可控释放,是生物医药领域的重要研究方向。海藻酸钠生物相容性好、易于修饰及加工形成微纳米颗粒,作为药物载体的应用研究日渐增多。综述了制备海藻酸钠纳米粒的4种方法,即离子交联法、乳化法、静电络合法和自组装法,并指出了4种方法的优缺点。     

球壳状纳米介孔腔内药物释放特性的分子动力学研究

有序纳米介孔材料的有序性、大的比表面积、孔道均匀等特性使其在药物装载、吸附、释放等方面得到广泛的应用。近年来研究者对介孔材料在药物控释方面的研究主要是通过材料制备、表征以及吸附药物后介孔材料的性能测试等几方面实现的。大多数报道都是采用实验的方法进行研究,关于模拟计算方面的研究很少,力场的选择更是模拟计算的一项挑战。依据介孔材料的独特结构构建了球壳状纳米介孔腔内药物分子释放模型,通过分子动力学的方法计算分析了药物分子的释放特性,重点考察了药物分子大小、溶液环境、介孔腔结构特征对其释放特性的影响。     

德国老年人药物管理系统设计研究

目的针对德国老年人用药问题进行分析,运用智能药物管理系统,提出解决方案。方法重点分析了德国人口老龄化产生的健康问题,阐述了老年用药方面的问题,提出了用药过程中针对患者、医生、药店有机结合的智能药物管理系统的设计原则和案例。结论人口的老龄化和老年人的健康是全球面临的问题,在"互联网+"健康的基础上,设计人性化的智能药物管理系统,可以为老年人健康生活带来更多的便利。     

Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location‐Specific Regulation of Cellular Behaviors

Growth factors are potent stimuli for regulating cell function in tissue engineering strategies, but spatially patterning their presentation in 3D in a facile manner using a single material is challenging. Micropatterning is an attractive tool to modulate the cellular microenvironment with various biochemical and physical cues and study their effects on stem cell behaviors. Implementing heparin's ability to immobilize growth factors, dual‐crosslinkable alginate hydrogels are micropatterned in 3D with photocrosslinkable heparin substrates with various geometries and micropattern sizes, and their capability to establish 3D micropatterns of growth factors within the hydrogels is confirmed. This 3D micropatterning method could be applied to various heparin binding growth factors, such as fibroblast growth factor‐2, vascular endothelial growth factor, transforming growth factor‐betas and bone morphogenetic proteins while retaining the hydrogel's natural degradability and cytocompability. Stem cells encapsulated within these micropatterned hydrogels have exhibited spatially localized growth and differentiation responses corresponding to various growth factor patterns, demonstrating the versatility of the approach in controlling stem cell behavior for tissue engineering and regenerative medicine applications.     

Let There be Light: Polymeric Micelles with Upper Critical Solution Temperature as Light‐Triggered Heat Nanogenerators for Combating Drug‐Resistant Cancer

Complete drug release and efficient drug retention are two critical factors in reversing drug resistance in cancer therapy. In this regard, polymeric micelles with an upper critical solution temperature (UCST) are designed as a new exploration to reverse drug resistance. The amphiphilic UCST‐type block copolymers are used to encapsulate photothermal agent IR780 and doxorubicin (DOX) simultaneously. The integrated UCST‐type drug nanocarriers show light‐triggered multiple synergistic effects to reverse drug resistance and are expected to kill three birds with one stone: First, owing to the photothermal effect of IR780, the nanocarriers will be dissociated upon exposure to laser irradiation, leading to complete drug release. Second, the photothermal effect‐induced hyperthermia is expected to avoid the efflux of DOX and realize efficient drug retention. Last but not least, photothermal ablation of cancer cells can be achieved after laser irradiation. Therefore, the UCST‐type drug nanocarriers provide a new strategy in reversing drug resistance in cancer therapy.     

Protein Interactome Analysis for Countering Pathogen Drug Resistance

Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial intera...     

药物信息服务实践应用的信度与效度分析

为建立科学的药物信息服务评价体系,我们采用问卷调查法对新疆医科大学第四附属医院药房及患者信息进行系统性调查,利用Excel和SPSSStatistics进行数据整理分析,采用Cronbach＇sAlpha系数、因子分析等方法对问卷做了信度和效度评价分析,初步提出了医院药物信息服务的要素．结果,本次研究的过程和方法为他人在药物信息乃至其它信息分析中提供重要的参考依据．     

基函数自适应选择的预测函数控制方法在混凝投加中的应用

传统预测函数控制算法的基函数是固定的,在控制环境不稳定的情况下控制品质不理想,本文提出一种通过对基函数的自适应选择来改善控制品质。本文根据过程输出值与期望值的误差来选择基函数,将全体误差分为几个区域,每个区域分别对应一个基函数,通过计算误差落选区域来选择对应的基函数。针对混凝投药过程的时滞原因,本文利用软测量方法建立一个混凝投药模型,应用该模型预测过程的输出。Matlab仿真表明此算法具有更好的平稳性和快速响应能力,比传统预测函数控制算法具有更好的控制品质。