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1Introduction Osteosarcoma,35%ofhumanprimarybonecan cers,ishighlymalignantandtendstotransferandgrow permeantly.Chemotherapyisaneffectiveandbasicthera pyforosteosarcoma,buttheside effectofantineoplasticdrugslimitstheconcentrationofthemwhichinfluences thecu… 相似文献
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Tobacco use is prevalent among youth with alcohol and other drug problems, yet this issue has received limited research and clinical attention. This study reports on a controlled evaluation of a cigarette smoking intervention with 54 adolescents in treatment for substance abuse, ages 13-18 (22% female). Participants were assessed at 4 time points. A greater proportion of participants in the treatment condition (n = 26) reported cessation attempts and point abstinence than did control participants (n = 28) at all time points. However, significant differences were found only for point abstinence at a 3-month follow-up. These findings provide initial support for the efficacy of a smoking cessation intervention delivered in the context of adolescent substance abuse treatment. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Mingna Song Melgardt M. de Villiers Anne-Marie Redelinghuys Wilna Liebenberg 《Particulate Science and Technology》2005,23(4):323-334
This study reports the crystallization of amorphous nifedipine during an interactive mixing process quantified by using isothermal and dynamic microcalorimetry. Interactive mixtures of amorphous nifedipine and uniform glass beads were prepared by mixing in a Turbula® mixer. The difference in the extent of crystallization of amorphous nifedipine during mixing was characterized by the time it took for the crystallization of a known amount of amorphous nifedipine in isothermal calorimetry and the change in the height of the crystallization peak at 65°C in dynamic calorimetry. It was found that both isothermal and dynamic microcalorimetry are useful techniques for quantifying the physical transition of amorphous nifedipine during interactive mixing. The rate and extent of crystallization of amorphous nifedipine depended on both mixing time and speed, but mixing time played a more dominant role because the transformation of amorphous to crystalline nifedipine was greater after 3180 revolutions (9.7%) than after 405 revolutions (0.9%) at 27 rpm. The same trend was observed at 109 rpm, but the percentage of crystalline nifedipine after 3180 revolutions was only 5.2%. This meant that an increase in mixing time rather than speed increased the rate of amorphous to crystalline transformation. The greatest cause for crystal transformation during interactive mixing was the presence of crystal seeds of the thermodynamically stable nifedipine Modification I because the amount of amorphous to crystalline transformation increased from 2.6% for a completely amorphous mixture to 6.6% for a 92:8 mixture of amorphous and crystalline nifedipine when mixed for 30 minutes at 106 rpm. 相似文献
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Mike Lafferty Mark J. Dycaico 《Journal of The Association for Laboratory Automation》2004,9(4):200-208
Recombinant approaches for tapping into the biodiversity present in nature for the discovery of novel enzymes and biosynthetic pathways can result in large gene libraries. Likewise, laboratory evolution techniques can result in large but potentially valuable libraries. Thorough screening of these libraries requires ultra high-throughput methods. The GigaMatrix™ screening platform addresses this opportunity using reusable high-density plates with 100,000 to 1,000,000 through-hole wells in a microplate footprint. In addition to throughputs of over 107 wells per day, the platform offers a significant reduction in reagent use and waste, has fully integrated automated “cherry picking,” and uses no complicated dispensing equipment. Wells containing putative hits from targeted fluorescent liquid phase assays are revealed by a fluorescent imaging system. Vision-guided robotics are utilized to recover hits by accessing individual 200 μm and smaller wells with a disposable sterile needle. The GigaMatrix platform has proven to be an effective and efficient tool for screening gene libraries for both discovery and evolution applications. 相似文献
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Laura Bix Sujit S. Sansgiry Robert Clarke Fernando Cardoso Gauri S. Shringarpure 《Packaging Technology and Science》2004,17(1):3-11
This study investigates the coverage of federally mandated information on over‐the‐counter (OTC) drug labels by electronic article surveillance (EAS) tags applied to the exterior of cartons. Using adult‐strength analgesics containing acetaminophen as a case study, researchers investigated the issue in Houston, Texas (24 stores) and Lansing, Michigan (33 stores). The information obscured by EAS tags was identified and classified for a total of 849 packages using a standardized data collection instrument. The results indicated that 293 packages examined, or 34.5%, had information mandated by the US Food and Drug Administration (US FDA) fully or partially obscured by the EAS tags. Retailers and manufacturers should be aware of such practices to reduce potential liability. Recommendations for improving EAS tag usage on OTC products are presented. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
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This article provides an overview of the factors that may contribute to the effective term of protection for a pharmaceutical product in the USA––by patent and by FDA market exclusivities, identifies public and commercial sources for collecting relevant patent term and exclusivity data, and provides a strategy for ensuring that the effective term of protection has been calculated accurately. 相似文献