浅谈水电站达标投产管理工作经验

工作实践证明,在水电站工程建设过程中开展达标投产工作,是全面提高工程建设质量水平的重要方法,有利于水电站整体竣工移交,有利于水电站一次投产发电,能够确保工程尽快发挥经济效益。本文内容是笔者在梨园水电站4年多参与达标投产工作的心得,对水电站建设工作者,具有积极的参考意义。     

基于置信度理论的网络知识融合系统和应用

由于网络知识资源的异构性,知识融合系统需要对多源数据、信息进行集成与整合并消除歧义.在知识融合过程中,由于知识科学的复杂性和模糊性,需要对多源知识的不一致、不完整等不确定性问题进行处理.基于此,提出了一种基于置信度理论的网络知识融合系统模型,弥补了传统知识融合系统在不确定性处理上的不足,并使用反馈自适应机制自动校正置信...     

Targeted,Needle‐Free Vaccinations in Skin using Multilayered,Densely‐Packed Dissolving Microprojection Arrays

Targeting of vaccines to abundant immune cell populations within our outer thin skin layers using miniaturized devices—much thinner than a needle and syringe, could improve the efficacy of vaccines (and other immunotherapies). To meet this goal, a densely packed dissolving microprojection array (dissolving Nanopatch) is designed, achieving functional miniaturization by 1) formulating small microneedles (two orders of magnitude smaller than a standard needle and syringe) and 2) multiple layering of the payload within microprojections with tight tolerances (of the order of a micrometer). The formulation method is suitable to many vaccines because it is without harsh or complex chemical processes, and it is performed at low temperatures and at a neutral pH. When the formulated dNPs are applied to skin, consistent and robust penetration is achieved, rapidly targeting the skin strata of interest (<5 min; significantly faster than larger dissolving microneedles that have been previously reported). Resultant diffusion is significantly enhanced within the dermis compared with the epidermis. Using two different antigens (ovalbumin and a commercial trivalent influenza vaccine [Fluvax2008]), the administration of these dissolving patches generate robust systemic immune responses in a mouse model. To the authors' knowledge, this is the first report of successful vaccination with any form of dissolving microneedles. The patches made by this method therefore have the potential for pain‐free, needle‐free, and effective vaccination in humans.     

Preparation and evaluation of gel formulations for oral sustained delivery to dysphagic patients

Background: Oral sustained release gel formulations may provide a means of administering drugs to dysphagic and geriatric patients who have difficulties with handling and taking oral dosage forms. Aim: We have designed gel formulations for the oral administration of paracetamol with suitable rheological characteristics for ease of administration to patients with swallowing difficulties and sufficient integrity in the acidic environment of the stomach to achieve a sustained release of this drug. Method: Gels formed by gelatin, agar, gellan, pectin, and xyloglucan were assessed for suitable gel strength and in vitro and in vivo release characteristics. Results: Gellan (1.5%?w/v) and xyloglucan gels (1.5%?w/w) had acceptable gel strengths for ease of swallowing and retained their integrity in the rat stomach sufficiently well to sustain the release of paracetamol over a period of 6 hours. Comparison of 1.5%?xyloglucan gels with a commercially available preparation with identical paracetamol concentrations demonstrated improved sustained release properties of the xyloglucan gels. Conclusions: Gels formed by gellan and xyloglucan have suitable rheological and sustained release characteristics for potential use as vehicles for oral delivery of drugs to dysphagic patients.     

Evaluation of dibutyrylchitin as new excipient for sustained drug release

Dibutyrylchitin (DBC), a lipophilic chitin diester, has been synthesized from chitin and butyric anhydride with methanesulfonic acid as catalyst. Exhaustive esterification of free alcoholic groups of chitin was assessed by FT-IR and ¹H-NMR spectroscopy. High degree of alkyl substitution allowed DBC to acquire an almost completely lipophilic character. Tablets of paracetamol and metformin employing DBC as major excipient, in comparison with starch, microcrystalline cellulose, lactose and polyvinylpyrrolidone, were prepared and rates of drug release were checked by dissolution test assays. DBC released drug at a lower rate than that of the other tested materials. A comparison study of rate release of metformin from DBC tablets and from metformin-hydroxypropyl methylcellulose prolonged release oral formulation available on the market has been also curried out. Under the same conditions and in the presence of the same amount of loaded drug, DBC released 64% of metformin whereas hypromellose-based tablets released 87%.     

Review of Brief psychotherapies: Principles and practices.

Reviews the book, Brief psychotherapies: Principles and practices by Michael F. Hoyt (2009). Despite the evident desire of many clients to address their issues in as time-efficient manner as possible (even one session), most therapists are trained to deliver psychotherapy via longer-term models of practice. Although more graduate programs than in the past are beginning to offer training in brief therapy, in many instances this is a one course elective without related practical experience. Hoyt’s book provides a wide-angle overview of the field of brief therapy, as well as an up close look at one of its most prominent models (Solution-Focused Therapy). In doing so, it could serve as a centerpiece for courses in brief psychotherapy. Time sensitive therapy fits in a time sensitive world—a world in which both the clients and funders of services want problems to be addressed in as focused a way as possible. This book teaches therapists a great deal about how to navigate in that world. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Amphiphilic Poly(Amino Acid) Nanoparticles Induce Size‐Dependent Dendritic Cell Maturation

Size‐regulated amphiphilic poly(amino acid) nanoparticles (NPs) composed of poly(γ‐glutamic acid) (γ‐PGA) and the hydrophobic amino acid derivative, L ‐phenylalanine ethyl ester (Phe) are prepared to evaluate the effects of particle size on dendritic cell (DC) uptake of NPs and their immune stimulatory activities as delivery carriers and adjuvants. The size of the Phe‐conjugated γ‐PGA NPs (γ‐PGA–Phe NPs) is easily controlled by regulating the aggregated γ‐PGA–Phe numbers. Each of the differently sized γ‐PGA–Phe NPs could efficiently encapsulate ovalbumin (OVA), and the amount of encapsulated OVA per milligram of NPs is almost the same despite the differences in size. The DC uptake of small NPs is lower than for the larger NPs, but the effect of DC activation by NPs is high in the small sizes. The DC activation is significantly affected by the size of the NPs, which suggests that not only the uptake process of the NPs, but also the surface interactions between the NPs and DCs, is important for the induction of DC maturation. The precisely size‐controllable γ‐PGA–Phe NPs have significant potential as an antigen carrier and vaccine adjuvant. These results should provide guidelines for adjuvant design in the development of an effective vaccine.     

The development of an advanced filial therapy model.

This article presents an advanced filial therapy model. This model was developed and implemented by the author in an effort to provide parents with ongoing support and skill development after the completion of a standardized filial model called Child–Parent Relationship Therapy. The advanced filial therapy model is described, including an exploration of how it was developed and how it compares with basic filial therapy models. Examples from the author's clinical experience are provided to illustrate various components of this approach. Finally, implications for research and practice are considered. (PsycINFO Database Record (c) 2010 APA, all rights reserved)