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51.
Sibylle Frase Franziska Lffler Jonas A. Hosp 《International journal of molecular sciences》2022,23(7)
Dopaminergic signaling is a prerequisite for motor learning. Delayed degeneration of dopaminergic neurons after stroke is linked to motor learning deficits impairing motor rehabilitation. This study investigates safety and efficacy of substance P (SP) treatment on post-stroke rehabilitation, as this neuropeptide combines neuroprotective and plasticity-promoting properties. Male Sprague Dawley rats received a photothrombotic stroke within the primary motor cortex (M1) after which a previously acquired skilled reaching task was rehabilitated. Rats were treated with intraperitoneal saline (control group, n = 7) or SP-injections (250 µg/kg) 30 min before (SP-pre; n = 7) or 16 h (SP-post; n = 6) after rehabilitation training. Dopaminergic neurodegeneration, microglial activation and substance P-immunoreactivity (IR) were analyzed immunohistochemically. Systemic SP significantly facilitated motor rehabilitation. This effect was more pronounced in SP-pre compared to SP-post animals. SP prevented dopaminergic cell loss after stroke, particularly in the SP-pre condition. Despite its proinflammatory propensity, SP administration did not increase stroke volumes, post-stroke deficits or activation of microglia in the midbrain. Finally, SP administration prevented ipsilesional hypertrophy of striatal SPergic innervation, particularly in the SP-post condition. Mechanistically, SP-pre likely involved plasticity-promoting effects in the early phase of rehabilitation, whereas preservation of dopaminergic signaling may have ameliorated rehabilitative success in both SP groups during later stages of training. Our results demonstrate the facilitating effect of SP treatment on motor rehabilitation after stroke, especially if administered prior to training. SP furthermore prevented delayed dopaminergic degeneration and preserved physiological endogenous SPergic innervation. 相似文献
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为了探明电化学修复对钢筋疲劳性能的影响,开展电化学除氯和双向电迁处理后钢筋的轴向拉伸疲劳试验. 基于断裂力学原理及断口微观形貌分析,揭示电化学修复技术引起钢筋疲劳性能变化的机理. 结果表明,电化学除氯会引起钢筋疲劳裂纹门槛值的减小及疲劳弹性模量的退化,宏观表现为钢筋疲劳寿命减小;电化学除氯后钢筋疲劳裂纹起源于钢中白点,裂纹扩展区疲劳辉纹间距增大,瞬断区韧窝变小变浅. 掺入阻锈剂的双向电迁方法对钢筋疲劳性能的负面影响较小,双向电迁修复后钢筋的疲劳断口微观形貌相对于普通钢筋未见明显变化. 相似文献
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It is argued that psychologists, through activities related to program evaluation, can make contributions to at least four pressing issues: participation in and formulation of public policy regarding rehabilitation; clarification of the nature and scope of rehabilitation itself; practice of theory-driven evaluation; and the cumulation of knowledge through meta-analytic methods. Papers in the Special Issue are briefly introduced and described. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Reviews the book, Home and Hospital Psychiatric Treatment by Fred R. Fenton, Lise Tessier, E. L. Struening, Frank A. Smith and Constance Benoit (1982). From 1972 to 1976, Fenton and his associates were involved in a study at the Montreal General Hospital's Department of Psychiatry that sought to compare a home-based psychiatric treatment program with a more traditional inpatient service. Their monograph presents the rationale for the study, describes the methodology employed, presents their findings and conclusions and discusses issues related to home-based treatment programs and their evaluation. From a methodological point of view, the study is not without its flaws. It does however represent an example of good research in a difficult (real world) setting. The study is well documented and findings are presented in a logical and comprehensible fashion. Its length and detail make it suitable for use as a case study in a class dealing with methodology or evaluation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Factor analysis of the attitudes of 133 rehabilitation and agency practitioners and trainees yielded four major factors: Coping-Succumbing, Emotional Need-Emotional Satisfaction, Sensitivity-Self-Consciousness, and Inferred Morality. The findings of this study are compared and contrasted with findings using similar instruments with different populations so as to explore psychometric issues. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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从电厂的水能和设备运行的现状,阐明了该工程进行增容改造的迫切性,以及经济财务分析的可行性,全面说明了电厂进行电气主接线、设备进行改造的方案. 相似文献
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在水环境监测结果分析与污染源调查的基础上,对台州城市核心区内河水环境状况恶化的原因进行了初步分析。从控制污染源和修复水环境两个方面入手,提出了控制污染源、加强岸线管理等措施。并从物理、化学、生物、生态等方面论述了进一步改善内河水环境的整治措施,主要包括增容、曝气增氧、生物治理、微生物治理、河水循环处理等技术。 相似文献