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21.
Luisa Siculella Laura Giannotti Benedetta Di Chiara Stanca Matteo Calcagnile Alessio Rochira Eleonora Stanca Pietro Alifano Fabrizio Damiano 《International journal of molecular sciences》2021,22(8)
Reactive intermediate deaminase (Rid) proteins are enzymes conserved in all domains of life. UK114, a mammalian member of RidA subfamily, has been firstly identified as a component of liver perchloric acid-soluble proteins (L-PSP). Although still poorly defined, several functions have been attributed to the mammalian protein UK114/RIDA, including the reactive intermediate deamination activity. The expression of UK114/RIDA has been observed in some tumors, arousing interest in this protein as an evaluable tumor marker. However, other studies reported a negative correlation between UK114/RIDA expression, tumor differentiation degree and cell proliferation. This work addressed the question of UK114/RIDA expression in human non-tumor HEK293 cell lines and in some human tumor cell lines. Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation. In HEK293, hRIDA K-succinylation was negatively correlated to the cell proliferation rate and was under the control of SIRT5. Moreover, K-succinylation clearly altered hRIDA quantification by immunoblotting, explaining, at least in part, some discrepancies about RIDA expression reported in previous studies. We found that hRIDA was able to deaminate reactive enamine-imine intermediates and that K-succinylation drastically reduced deaminase activity. As predicted by in silico analysis, the observed reduction of deaminase activity has been related to the drastic alterations of hRIDA structure inferred by K-succinylation. The role of hRIDA and the importance of its K-succinylation in cell metabolism, especially in cancer biology, have been discussed. 相似文献
22.
XIE Changsheng SUN Peizhen ZHAO Jiansheng CHEN Yuqiu Huazhong University of Science Technology Wuhan China XIE Changsheng Associate Professor Department of Mechanical Engineering No. Huazhong University of Science Technology Wuhan China 《金属学报(英文版)》1990,3(1):52-57
The microstructures of Fe-Mn-Ni-Cr steels with medium carbon and the effect of alloy ele-ments on them have been investigated by means of X-ray diffraction quantitative phase ana-lyses,metallography and hardness tests.The volume fraction of martensite in steels quenchedat 1100℃ can be expressed as:f_M~(1100)=162.643-15.482Mn-7.36Ni-4.286(Cr+Mo+V)Based on this expression,the quasi-equilibrium microstructure diagram has been obtained.Itis shown that the effect of Mn on the austenite stability is greater than that of Ni.The equiva-lent [Ni]=2.104Mn+Ni and equivalent [Cr]=Cr+Mo+V.The driving force for martensite transformation at M_s point has been calculated to hedrastically decreased by element Mn. 相似文献
23.
本文利用X射线定量相分析及金相观察和硬度测试,考察了中碳Fe-Mn-Ni-Cr钢的组织及合金元素的作用。建立了经1100℃淬火后的马氏体体积分数与合金成分的定量关系式; f_M~(1100)=162.643-15.482Mn-7.36Ni-4.286(Cr+Mo+V)并在此基础上给出了亚平衡组织图。结果表明,Mn稳定奥氏体的作用大于Ni的作用。Ni和Cr当量分别以[Ni]=2.104Mn+Ni,[Cr]=Cr+Mo+V表示。计算了M_S点处的马氏体相变驱动力,指出Mn具有强烈降低相变驱动力的作用。 相似文献
24.
本文针对我厂650×3中型轧钢机用主减速机当前的工作条件和轧制负荷情况,该减速机的设计特点、传动布置力学原则、使用维护经验等几个方面进行系统分析,并结合其运动现状和工作情况趋向,以探讨该减速机良好的工作可靠性和长期使用寿命的成因。 相似文献
25.
我国木质素油田化学品的发展现状 总被引:7,自引:0,他引:7
马宝岐 《纤维素科学与技术》1994,(Z1)
本文综述了我国木质素类(碱木质素或木质素磺酸盐)油田化学品的最新进展,其中包括钻井液处理剂、油井水泥添加剂、堵水剂、调剖剂、稠油降粘剂和表面活性剂驱油的牺牲剂。目前我国木质素类堵水剂、调剖剂和稠油降粘剂的研究和应用方面已达到或超过世界先进水平,改性木质素磺酸盐的研究也接近国际先进水平,但钻井处理剂和水泥添加剂仅为美国的1/9,许多木质素化学品仍为空白。因此,这些油田化学品仍然是吸引人去研究的课题,期望不久的将来会有较大的进展。 相似文献
26.
热塑性复合材料用混纤预浸料特征 总被引:1,自引:0,他引:1
本文对热塑性复合材料用预浸料的结构及其在复合材料成型加工中的浸渍性能进行分析. 相似文献
28.
The effectiveness of an active shutter-glasses stereoscopic display (SD) and a passive polarised SD was evaluated in a live robot-teleoperation task and a simulated indirect-vision driving task in various terrains. Overall, participants completed their tasks significantly faster with the SDs in three-dimensional (3D) mode than with the SDs in the baseline 2D mode. They also navigated more accurately with the SDs in 3D mode. When the effectiveness of the two types of SDs was examined separately, results showed that the active shutter-glasses SD resulted in faster responses and task completion times than the passive polarised SD, though most of the differences failed to reach statistical significance. Perceived workload when interacting with the two SD systems did not differ significantly between the active versus passive display types or between the 3D and 2D modes of operation; however, participants reported more severe discomfort after interacting with the passive polarised SD. 相似文献
29.
农药品种及其原料中间体的现状和展望 总被引:4,自引:0,他引:4
介绍了近年来新开发的农药品种及所需的原料和中间体,并提出了发展建议。 相似文献
30.