TMT-HCC: A tool for text mining the biomedical literature for hepatocellular carcinoma (HCC) biomarkers identification

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. New insights into the pathogenesis of this lethal disease are urgently needed. Chromosomal copy number alterations (CNAs) can lead to activation of oncogenes and inactivation of tumor suppressors in human cancers. Thus, identification of cancer-specific CNAs will not only provide new insight into understanding the molecular basis of tumor genesis but also facilitate the identification of HCC biomarkers using CNA.     

Mining temporal explicit and implicit semantic relations between entities using web search engines

In this paper, we study the problem of mining temporal semantic relations between entities. The goal of the studied problem is to mine and annotate a semantic relation with temporal, concise, and structured information, which can release the explicit, implicit, and diversity semantic relations between entities. The temporal semantic annotations can help users to learn and understand the unfamiliar or new emerged semantic relations between entities. The proposed temporal semantic annotation structure integrates the features from IEEE and Renlifang. We propose a general method to generate temporal semantic annotation of a semantic relation between entities by constructing its connection entities, lexical syntactic patterns, context sentences, context graph, and context communities. Empirical experiments on two different datasets including a LinkedIn dataset and movie star dataset show that the proposed method is effective and accurate. Different from the manually generated annotation repository such as Wikipedia and LinkedIn, the proposed method can automatically mine the semantic relation between entities and does not need any prior knowledge such as ontology or the hierarchical knowledge base. The proposed method can be used on some applications, which proves the effectiveness of the proposed temporal semantic relations on many web mining tasks.     

水采向综采转型期间应把握的几个关键问题

峻德煤矿将半机械化水采工艺改为机械化采煤工艺,既适应煤矿地质条件要求,又提高了矿井机械化程度,促进了该矿向高产高效矿井发展。     

矿用产品安标现场评审前的注意事项

通过介绍安标现场评审的概念、流程、依据及准则,对安标评审13项准则和煤矿及非煤矿山生产企业需注意问题进行具体分析,使生产企业更深入的了解安标现场评审准则及评审前需注意的问题,做好充分的评审准备工作,从而顺利的通过安标现场评审。     

复采工作面火灾事故案例分析与综合防治

以小煤矿严重破坏区复采综放工作面3起火灾事故为案例,分析火灾原因,提出了复采工作面穿越小煤矿破坏区特殊支护、消火道防灭火等防治小煤矿自然发火技术,结合工作面破坏区灌浆超前防治、局部均压、注氮等防灭火措施,有效地消除了火灾事故,确保工作面顺利回采。     

Efficacy of non-thermal technologies and sanitizer solutions on microbial load reduction and quality retention of strawberries

The effect of non-thermal technologies (ozone in aqueous solution, ultrasound and ultraviolet C radiation) and washings with chemical solutions (sodium hypochlorite and hydrogen peroxide) on safety and quality features of strawberries was studied. These treatments were applied before fruit storage at two different temperatures (4 and 15 °C). The overall impact on microbial loads (total mesophiles, and yeasts and moulds) and selected quality attributes (colour, firmness, pH, total anthocyanins and ascorbic acid content) was assessed.During storage under refrigerated temperature, washing with hydrogen peroxide solutions resulted in strawberries with lower microbial loads, when compared to the other treatments. However, it produced significant key quality attributes losses, such as colour and total anthocyanins content.The results presented show that ozone and ultrasound are promising alternatives to thermal treatments. The application of such technologies, before refrigerated storage of strawberries, allowed a satisfactory retention of all quality characteristics analysed, while being efficient in controlling microbial contamination.     

数据挖掘在医院智能审计与监管平台系统中的应用

审计是经济活动中非常重要的环节,它承担着审查监督、揭露经济犯罪等重要任务。然而在面对几何增长的数据量的时候,审计人员很难找到数据中隐藏的重要信息,影响自己的判断力。基于如此宏大的数据量,提出将数据仓库、数据挖掘及其算法应用到审计中,分析当前数据,对后期数据进行预测评估,为审计人员的决策提供数据支持。     

VCR采矿法在武山铜矿应用展望

为进一步提高武山铜矿综合采矿效益，根据武山铜矿地质条件、采矿经验，并结合安全、成本、效益等因素，浅述后期生产建设过程中如何发挥现有采矿方法的优势，并针对 VCR 采矿法在武山铜矿应用现状，分析了改进提升的方法。     

基于新标准的俄罗斯釆金业职业风险评估

当前俄罗斯正在进行立法改革以实现治理体系现代化，其中改革的重点是国家管理体系中的劳动保护、工业安全和突发事件的应急处理。过去的立法体系侧重于对受伤员工提供健康补偿和医疗救护，而新的立法体系则以预防为主，以期通过建立完善的风险管理机制和运行规则，提高安全生产水平、普及安全文化教育，保障员工的生命安全。新标准强调企业必须进行职业风险评估，并将职业风险评估纳入企业工作管理体系。论文以采金业为例，选取伊尔库茨克州波戴波区金矿露天采场为研究案例，探讨了现代化职业风险评估的方法，明确了职业风险评估首先要进行危害鉴别，编制了风险源管理档案清单。采用实测员工风险因素的“记分法”和数学模拟“矩阵法”完成了伊尔库茨克州波戴波区金矿露天采场主要职业的风险评估。研究表明: 在钻井爆破作业场所，由碎石的喷射、粉尘的排放和噪声效应引起的危险为不可接受风险，通过实施安全生产制度（即遵守安全标准和技术要求、为工人提供防护装备）,可将高风险和不可接受风险化解为可接受风险；阐述了高风险职业，编制了风险手册，提出了改善工作条件的首要措施是消除影响爆破手和钻机操作员的有害因素，并为员工提供能更有效预防噪音和振动的个人防护用品。     

Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: <i>In silico</i> toxicogenomic approach

This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www.disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.