跨通路实验模式的视觉失匹配负波研究

采用视听觉的跨通路刺激实验模式,通过对ERP实验数据的分析发现:在非注意条件下,顶叶和颞叶的负电位波形不规则,且一致性差;而额叶及枕叶(接近视觉初级投射区)均出现了较明显的视觉早期偏差相关负成分,其潜伏期范围在140~170 ms之间,存在通道特异性,与听觉MMN类似。据此得出:视觉早期偏差相关负成分应该是由视觉通路痕迹产生的视觉MMN;视觉早期偏差相关负成分的源有两个,一个位于额叶,另一个位于初级视皮层所在的枕叶处。     

Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology

Prevalence of type 2 diabetes increased from 2.5% of the US population in 1990 to 10.5% in 2018. This creates a major public health problem, due to increases in long-term complications of diabetes, including neuropathy, retinopathy, nephropathy, skin ulcers, amputations, and atherosclerotic cardiovascular disease. In this review, we evaluated the scientific basis that supports the use of physiologic insulin resensitization. Insulin resistance is the primary cause of type 2 diabetes. Insulin resistance leads to increasing insulin secretion, leading to beta-cell exhaustion or burnout. This triggers a cascade leading to islet cell destruction and the long-term complications of type 2 diabetes. Concurrent with insulin resistance, the regular bursts of insulin from the pancreas become irregular. This has been treated by the precise administration of insulin more physiologically. There is consistent evidence that this treatment modality can reverse the diabetes-associated complications of neuropathy, diabetic ulcers, nephropathy, and retinopathy, and that it lowers HbA1c. In conclusion, physiologic insulin resensitization has a persuasive scientific basis, significant treatment potential, and likely cost benefits.     

车内空腔声学模态试验与仿真分析

以某中型商用车为研究对象,基于LMSTest．Lab模态分析系统对车内空腔进行了声学模态试验与分析,获取了声学模态频率和模态振型,将声学模态与结构模态频率作对比,可以避开关键频率的声固耦合,减少低频噪声,同时建立该车空腔的有限元模型,进行了声学模态的仿真计算,为车内噪声的研究提供了参考,对改善其车内声学特性具有一定的指导意义。     

基于实验模态和有限元分析的轧机故障诊断

针对某钢厂热连轧机在轧制过程中出现的异常振动现象，分别对轧机机架和传感器壳进行了实验模态分析，得出轧机异常振动是由于机架和传感器壳的自激振动，引起传感器连接杆和传感器壳的不合理相对运动耦合的结论；然后采用实验模态分析和有限元建模相结合的建模方法，获得了足够精度的传感器壳修正模型。最后对传感器壳修正模型进行结构动力学修改，修改后，消除了异常振动，解决了该热连轧机的自激振动。     

Al2O3/ZrO2(Y2O3)复合材料的可靠性、磨损形态及其切削耐用度

研究了Al2O3和Al2O3/ZrO2(Y2O3)复合刀具材料的Weibull分布、磨损形态及其切削耐用度。用一元线性回归方法确定Al2O3/ZrO2(Y2O3)刀具的耐用度参数,分析切削条件对Al2O3/ZrO2(Y2O3)复合刀具材料寿命的影响。结果表明:Al2O3和含2%(摩尔分数)及3%Y2O3的ZrO2/Al2O3(Al2O3/ZrO2(2Y)及Al2O3/ZrO2(3Y))复合刀具材料Weibull模数的m值分别是5.6、10.2和11.7,说明Al2O3/ZrO2(3Y)陶瓷的可靠性最优;Al2O3/ZrO2(3Y)复合刀具切削40CrMoNiA合金钢的磨损形态主要来自磨粒磨损和粘结磨损,耐用度参数vc、f、ap的指数值分别为1.3、1.69和0.66,陶瓷刀具更适合高速切削,最大影响因素是进给量(f),在最佳切削条件下(vc=140 m/min,ap=0.5 mm和f=0.3 mm/r)切削耐用度为3 h。     

PET-CT双模图像配准

目前,医疗图像设备层出不穷,各种图像格式相继诞生.医疗图像所包涵的信息丰富程度和准确度直接影响到医生诊断治疗的结果.此篇文章以提供信息更为丰富、更为准确的多模图像,以便于医生临床的诊断治疗为目的,应用了刚性校正与双线性插值算法,以及聚类算法实现单模态PET与PET图像之间的配准,CT与CT图像之间的配准,与PET-CT图像的双模配准, 这些方法在实际临床医学应用中有着重要的用途,对医生判断病灶的情况和确切位置有很大的帮助.     

Application of Finger Span Cross Modality Matching Method (FSCM) by Naive Assessors for Olfactometric Discrimination of Gewürztraminer Wines

A gas-chromatography-olfactometric detection (GCO) using a direct estimation of odor intensities with the finger span (FSCM) was used to establish aroma profiles of three wines of gewürztraminer from different ‘terroirs’ of the Alsace region. The GCO-FSCM analyses of their hydroalcoholic wine extracts were performed using a group of untrained assessors. Forty-four olfactory signals were perceived by at least four assessors out of six and their intensities were scored in triplicate in each of the three wine extracts, amongst which ten of them were found discriminant between wines. The reliability of each assessor was studied on the basis of the finger span estimation repeatability, from the number of discriminant variables and the mean finger span values found for the assessor. These untrained assessors appear to be able to achieve self-calibration from odor intensities without using any internal of external quantitative reference. The results suggest that GCO-FSCM may be performed by naive assessors to analyse and compare odor profiles of complex extracts without time-consuming training periods.     

Transfer of noncorresponding spatial associations to the auditory Simon task.

Four experiments examined transfer of noncorresponding spatial stimulus-response associations to an auditory Simon task for which stimulus location was irrelevant. Experiment 1 established that, for a horizontal auditory Simon task, transfer of spatial associations occurs after 300 trials of practice with an incompatible mapping of auditory stimuli to keypress responses. Experiments 2-4 examined transfer effects within the auditory modality when the stimuli and responses were varied along vertical and horizontal dimensions. Transfer occurred when the stimuli and responses were arrayed along the same dimension in practice and transfer but not when they were arrayed along orthogonal dimensions. These findings indicate that prior task-defined associations have less influence on the auditory Simon effect than on the visual Simon effect, possibly because of the stronger tendency for an auditory stimulus to activate its corresponding response. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A within-modality test of semantic knowledge: The Size/Weight Attribute Test.

Individuals with semantic dementia (SD; n=12) or Alzheimer's disease (AD; n=20) and healthy volunteers (n=40) were tested on tasks probing attribute rather than associative knowledge of animals and objects in the visual and verbal domains. The tasks were within modality, in that they probed knowledge in a single presentation modality (pictures or written words) and did not require cross-modal matching. Participants were required to make the same simple judgment about triads of animal stimuli ("Which is the largest and smallest?") and object stimuli ("Which is the heaviest and lightest?"). Control participants scored at ceiling on this simple task. Overall, the SD patients were significantly more impaired on this task than were the AD patients, who in turn were significantly more impaired than the controls. There was a strong trend for SD but not AD patients to show worse performance with verbal than visual material. However, no significant effects of category were found in either patient group. The Size/Weight Attribute Test has the potential to assess modality-specific deficits of semantic knowledge. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

轿车车内空腔声模态测量

介绍了轿车车内空腔声学模态,对实车的声模态进行了测试与分析,获得了车内空腔的声学共鸣频率和模态形状;提出了利用LMSTest_lab对轿车车内空腔声学模态进行测试的试验方法,为车内空腔的低频噪声研究提供了参考。