Allowing for missing genotypes in any members of the nuclear families in transmission disequilibrium test

The Transmission Disequilibrium Test (TDT) detects linkage between a marker and a disease-susceptibility locus in the presence of linkage disequilibrium. The TDT requires data on the genotypes of affected offspring and their parents, which might not always be available. For example, for late onset diseases it might be difficult to find parents still alive, or genotypes of offspring might not be available. Genotyping unaffected siblings, combining different genotype data sets, or assuming a model mechanism for missing parents have all been proposed to deal with missing genotypes in parents but not in offspring. In this paper, we propose a Mendel Inheritance-Transmission Disequilibrium Test (MI-TDT) to impute missing genotypes in any members of a family with two affected offspring. Our method does not require any of the remedies mentioned above but simply utilizes the fundamental property of Mendel Inheritance on the transmission of alleles from parents to offspring. Most importantly, the MI-TDT reassures researchers about the declared significant genes when incomplete data is ignored. We illustrate the MI-TDT by identifying significant genes in type 1 diabetes from the Warren families in the United Kingdom.     

南京某高校宿舍潮湿与呼吸道疾病症状关系的研究

研究通过调查问卷的形式,收集学生身体健康与宿舍环境的信息,并利用SPSS对数据进行整理分析,旨在得出高校宿舍潮湿与学生呼吸道疾病症状之间的关系.研究结果表明57.9%的同学报告宿舍出现潮湿表征,43%的同学在最近12个月内出现呼吸道疾病症状,室内潮湿与学生呼吸道疾病症状之间存在显著相关性(P<0.05),室内的潮湿表征是呼吸道疾病症状爆发的危险因素(OR 2.362 95%CI),同时,研究发现学生呼吸道疾病症状的爆发以及室内潮湿表征与宿舍朝向有关.     

Work organisation constructs and ergonomic outcomes among European forest machine operators

The aims of the study were to: 1) create work organisation constructs for forest machine operators; 2) examine relationships between these work organisation constructs and different ergonomic outcomes. The study was carried out among forest machine operators in six European countries and was based on a questionnaire survey (n = 358). Exploratory factor analysis (EFA) was used in the formation of the construct measures of work organisation. The EFA resulted in a five-factor structure. The factors were named ‘job control’, ‘variation’, ‘job rotation’, ‘breaks’ and ‘rate of work’. Three multiple regression analyses were carried out separately for the dependent variables job satisfaction, musculoskeletal symptoms and headache/sleeping problems. All regression analyses resulted in significant overall models. The highest explained variance among the dependent variables was found for job satisfaction (R = 0.51, i.e. ‘large’ effect size). The unique contribution of the work organisation constructs varied in the models, but ‘job rotation’ contributed significantly in all regression models. The results may be used as a source for ergonomic improvements to work organisation. The present study was performed as part of the EU project ‘ErgoWood’, which resulted in a European handbook for mechanised forest operations (Gellerstedt et al. 2005 Gellerstedt S. Lidén E. Bohlin F Health and performance in mechanised forest operations The Swedish University of Agricultural Sciences, Department of Forest Products and Markets Uppsala 2005  [Google Scholar]). The results delivered part of the evidence base for a toolbox in this handbook regarding changes in work organisation to improve health and performance.     

Predicting Future Antisocial Personality Disorder in Males From a Clinical Assessment in Childhood.

It is essential to identify childhood predictors of adult antisocial personality disorder (APD) to target early prevention. It has variously been hypothesized that APD is predicted by childhood conduct disorder (CD), attention-deficit/hyperactivity disorder (ADHD), or both disorders. To test these competing hypotheses, the authors used data from a single childhood diagnostic assessment of 163 clinic-referred boys to predict future APD during early adulthood. Childhood Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987) CD, but not ADHD, significantly predicted the boys' subsequent APD. An interaction between socioeconomic status (SES) and CD indicated that CD predicted APD only in lower SES families, however. Among children who met criteria for CD, their number of covert but not overt CD symptoms improved prediction of future APD, controlling for SES. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stress Generation, Avoidance Coping, and Depressive Symptoms: A 10-Year Model.

This study examined (a) the role of avoidance coping in prospectively generating both chronic and acute life stressors and (b) the stress-generating role of avoidance coping as a prospective link to future depressive symptoms. Participants were 1,211 late-middle-aged individuals (500 women and 711 men) assessed 3 times over a 10-year period. As predicted, baseline avoidance coping was prospectively associated with both more chronic and more acute life stressors 4 years later. Furthermore, as predicted, these intervening life stressors linked baseline avoidance coping and depressive symptoms 10 years later, controlling for the influence of initial depressive symptoms. These findings broaden knowledge about the stress-generation process and elucidate a key mechanism through which avoidance coping is linked to depressive symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Roles of Sexual Objectification Experiences and Internalization of Standards of Beauty in Eating Disorder Symptomatology: A Test and Extension of Objectification Theory.

This study extends the literature on eating disorder symptomatology by testing, based on extant literature on objectification theory (B. L. Fredrickson & T. Roberts, 1997) and the role of sociocultural standards of beauty (e.g., L. J. Heinberg, J. K. Thompson, & S. Stormer, 1995), a model that examines (a) links of reported sexual objectification experiences to eating disorder-related variables and (b) the mediating roles of body surveillance, body shame, and internalization of sociocultural standards of beauty. Consistent with hypotheses, with a sample of 221 young women, support was found for a model in which (a) internalization of sociocultural standards of beauty mediated the links of sexual objectification experiences to body surveillance, body shame, and eating disorder symptoms, (b) body surveillance was an additional mediator of the link of reported sexual objectification experiences to body shame, and (c) body shame mediated the links of internalization and body surveillance to disordered eating. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-administered preventive programme for sedentary workers: reducing musculoskeletal symptoms or increasing awareness?

The objective of this study was to evaluate an auto-instructional preventive programme designed to allow the subjects to identify critical aspects related to their work and musculoskeletal comfort, and provide them with some simple alternatives for controlling the identified problems. The programme was evaluated by 36 secretaries and bank clerks through their symptom perception before and after the programme. The results showed that the symptoms increased in number and severity. The programme seemed to have helped the participants to become aware of the ergonomic problems present in their job and to link these problems to physical symptoms. Self-administered preventive programmes can lead to clearly negative results when applied as the only measure to control musculoskeletal symptoms.     

The Affective Structure of Supportive Parenting: Depressive Symptoms, Immediate Emotions, and Child-Oriented Motivation.

This study investigated the maternal concerns and emotions that may regulate one form of sensitive parenting, support for children's immediate desires or intentions. While reviewing a videotape of interactions with their 1-year-olds, mothers who varied on depressive symptoms reported concerns and emotions they had during the interaction. Emotions reflected outcomes either to children (child-oriented concerns) or to mothers themselves (parent-oriented concerns). Child-oriented concerns were associated with fewer negative emotions and more supportive behavior. Supportive parenting was high among mothers who experienced high joy and worry and low anger, sadness, and guilt. However, relations depended on whether emotions were child or parent oriented: Supportive behavior occurred more when emotions were child oriented. In addition, as depressive symptoms increased, mothers reported fewer child-oriented concerns, fewer child-oriented positive emotions, and more parent-oriented negative emotions. They also displayed less supportive behavior. Findings suggest that support for children's immediate intentions may be regulated by parents' concerns, immediate emotions, and depressive symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Influence of Prior Commitment on the Reactions of Layoff Survivors to Organizational Downsizing.

Nurses (N := 179; Study 1) and managers (N = 154; Study 2) participated in 2 panel studies examining the relationship among prior commitment (affective and continuance commitment and perceived organizational support), coping strategies, and survivors' attitudes and perceptions during and following downsizing. In Study 1, perceived organizational support was significantly positively related to control-oriented coping, job satisfaction, and intention to remain and negatively related to perceived job insecurity and burnout 2 years later. In Study 2, coping mediated the relationship between the prior commitment variables and job alienation, health symptoms, and burnout following the downsizing. Control-oriented coping was associated with elevated levels of health symptoms and burnout following the downsizing, suggesting that control-oriented coping may have positive effects in the short term but potentially harmful effects in the long term. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parent and Child Psychological Factors in Pediatric Syncope and Other Somatic Symptoms.

The authors examined associations among parental and child adjustment, child syncope, somatic, and school problems. Participants were children (N = 56) ages 7-18 years with syncope. Measures included syncope severity, parental distress, and children's internalizing symptoms. For children diagnosed negative for neurocardiogenic syncope (NCS), their fathers' and their own psychological symptoms were positively associated with the severity of syncope, whereas their mothers' functioning was negatively associated with the severity of syncope. Also, for the negative NCS group, fathers' psychological functioning was associated with children's nonsyncope somatic complaints but not with their school problems. For the positive NCS group, few significant father-child associations were found, but several significant positive associations were revealed between mothers' psychological symptoms and their children's syncope as well as somatic and school problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)