NF-κB regulates prenatal stress-induced cognitive impairment in offspring rats.

The study was designed to investigate whether nuclear factor of kappa B (NF-κB) plays regulating role in prenatal stress-induced cognitive impairment and oxidative damage in offspring rats. The authors used a rat model to study plasma levels of corticosterone and oxidative DNA damage (8-OH-dG), protein expression of P65/p50 NF-κB, and cognitive function in female and male offspring rats in middle pregnant stage and later pregnant stage. Prenatal stress affected the capability of learning and memory in the offspring, especially in later stage stressed female offspring. The levels of corticosterone and 8-OH-dG were enhanced in response to stress. Both middle and later stage stresses induced a significant decrease in P65 expression and a significant increase in P50 expression in female offspring. In addition, later stage stress induced a significant decrease in P50 expression in male offspring. These results suggest that NF-κB complex may be acting in a positive regulatory fashion in prenatal stress-induced cognitive impairment and that oxidative DNA damage may exacerbate the activation of NF-κB. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The use of acceptance and commitment therapy to prevent the rehospitalization of psychotic patients: A randomized controlled trial.

The present study examined the impact of a brief version of an acceptance-based treatment (acceptance and commitment therapy; ACT) that teaches patients to accept unavoidable private events; to identify and focus on actions directed toward valued goals; and to defuse from odd cognition, just noticing thoughts rather than treating them as either true or false. Eighty inpatient participants with positive psychotic symptoms were randomly assigned to treatment as usual (TAU) or to 4 sessions of ACT plus TAU. ACT participants showed significantly higher symptom reporting and lower symptom believability and a rate of rehospitalization half that of TAU participants over a 4-month follow-up period. The same basic pattern of results was seen with all participant subgroups except delusional participants who denied symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Indoor air pollution from biomass combustion and respiratory symptoms of women and children in a Zimbabwean village

Rural areas of developing countries are particularly reliant on biomass for cooking and heating. Women and children in these areas are often exposed to high levels of pollutants from biomass combustion that is associated with a range of respiratory symptoms. Domestic exposure to carbon monoxide (CO) and respirable particles (RSPs) in association with respiratory symptoms among women and children in Zimbabwe was investigated in 48 households. Health status and household characteristics were also recorded. In this study, indoor levels of CO and RSPs exceeded World Health Organization (WHO) air quality guidelines in over 95% of kitchens. The level of indoor air pollutants was associated with the area of kitchen windows and the length of cooking time combined with the level of fire combustion. Prevalence of respiratory symptoms was 94% for women and 77% for children. In addition, women reporting respiratory symptoms were exposed to higher levels of RSPs when compared with those reporting no respiratory symptoms. The study results indicated that levels of indoor air pollutants in rural Zimbabwe may contribute to respiratory symptoms in both women and children. PRACTICAL IMPLICATIONS: Levels of respirable particles and carbon monoxide in kitchens in rural Zimbabwe are unacceptably high and measures to reduce levels should be undertaken. Based on the study findings, recommendations for increasing the area of kitchen windows may be considered as a practical method of reducing indoor air pollutants in rural Zimbabwe.     

Building-related symptoms and inflammatory potency of dust from office buildings

The aim was to investigate the association between building-related symptoms (BRS) in office buildings and the inflammatory potency of dust (PD). Furthermore, the association between dust potency and various building characteristics was investigated. Occupants of 22 office buildings received a retrospective questionnaire about BRS (2301 respondents). Dust was collected from groups of offices and building characteristics were recorded. The potency of a dust sample to induce interleukin-8 (IL-8) secretion from the lung epithelial cell line A549 was measured as the slope of the initial linear part of the concentration-response curve. Symptoms of the central nervous system (CNS) were associated with the potency of surface dust (OR = 1.4). This association may be due to an association between an index of CNS symptoms and dust potency in offices of 1-6 occupants (OR = 1.5). No single symptoms correlated with the potency of surface dust. The PD was not related to single building factors. The inflammatory PD may be used as an integrated proxy measure of biologically active compounds in dust, reflecting health relevant properties of the dust. PRACTICAL IMPLICATIONS: The potency of surface dust may be used as a crude measurement of the chemical and biological exposures present in the building, and being associated with the development of central nervous system symptoms. However, additional research is needed to establish the predictive value of the potency of surface dust.     

Marriage as a risk factor for internalizing disorders: Clarifying scope and specificity.

Objective: Marital discord has been linked to both depression and anxiety; however, our understanding of how marriage contributes to the development of internalizing symptoms is limited in scope and lacking specificity. First, it is unclear whether the marital relationship contributes to the broad dimension of internalizing symptoms as opposed to specific diagnoses. Second, it is unclear how the marital relationship contributes to internalizing symptoms: through global marital dissatisfaction or through specific relationship processes (and which processes). The purpose of the present study was to address these 2 issues and, more generally, to develop a comprehensive and refined framework within which to understand the role of marriage in the developmental course of internalizing symptoms. Method: Questionnaire and interview data were collected from 102 husbands and wives 5 times over the first 7 years of marriage. Results: Results indicated that marital discord during the transition into marriage was associated with the broad dimension of internalizing symptoms for husbands but not for wives. Further, both global marital dissatisfaction and an imbalance of power and control put husbands at significant risk for symptoms over the first 7 years of marriage, whereas low levels of emotional intimacy put wives at significant risk. Conclusions: Results exemplify the need to routinely consider intimate relationship processes in etiological models of depression and anxiety and to identify specific clinical targets that can be prioritized in interventions aimed at preventing internalizing disorders. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

évolution du trouble d’opposition et du trouble des conduites au cours de l’enfance.

This study aimed at describing the evolution of the symptoms of the oppositional disorder and conducts disorder on a 4-year period (3 times of measurement), depending on whether both disorders appear simultaneously or separately. The sample was composed of 336 children (6–13 years-old), separated in three groups according to the nature of the disorder they presented at the beginning of the study: oppositional disorder only, conducts disorder only, both oppositional and conducts disorders. Structured diagnostic interviews based on the diagnostic criterions of the Diagnostic and Statistical Manual of Mental Disorders (4 éd., texte rév.; American Psychiatric Association, 2000) were used in order to evaluate the average number of symptoms associated to each disorder at each time of measurement. Multilevel regression analysis suggest that the initial co-occurrence of the disorders is neither associated to the evolution of the symptoms of the conducts disorder nor to those of the oppositional disorder. However, this co-occurrence, that can also include the attention-deficit/hyperactivity disorder, can increase the number of symptoms in children, which likely contributes to maintain the diagnostics in some cases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Imagery rehearsal therapy: An emerging treatment for posttraumatic nightmares in veterans.

Nightmares are a common complaint among service members exposed to traumatic events, but prevailing paradigms are disposed to a view that nightmares are a secondary phenomenon untreatable with direct therapeutic intervention. Imagery rehearsal therapy is a cognitive-imagery approach with proven efficacy in the treatment of nightmares in civilian trauma victims. Imagery rehearsal therapy not only has potential to reduce nightmare intensity and frequency, but controlled studies show clinically meaningful decreases in all clusters of posttraumatic stress disorder symptoms as well as insomnia. Limited data support its use with combat veterans. Directions for future research with combat veterans are recommended. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Understanding a link between sexual harassment and eating disorder symptoms: A mediational analysis.

Using data from 3 samples of working women and men, the present study examines the association between sexual harassment and eating disorder symptoms by studying the processes that may underlie this relationship. The results of structural equation modeling suggest a link between sexual harassment and eating disorder symptoms among women and indicate that this relationship is mediated by psychological distress, self-esteem, and self-blame. Further, sexual harassment was found to predict eating disorder symptoms among women even when experiences of sexual assault were included in the model. No relationship was found between sexual harassment and eating disorder symptoms among men. The theoretical and clinical implications of these results are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adjustment to a dyadic stressor: A longitudinal study of coping and depressive symptoms in infertile couples over an insemination attempt.

In a study designed to examine how intimate partners' coping processes with regard to infertility predicted depressive symptoms across the course of a treatment cycle, 43 couples completed assessments in the week prior to and the week after receiving a negative pregnancy result from an alternate insemination attempt by the partner. Depressive symptoms in both partners increased significantly after the pregnancy result receipt. As hypothesized, avoidant coping predicted increased distress over time, and approach-oriented coping (e.g., problem-focused coping, emotional processing, and expression) predicted decreased distress. Coping strategies engaged in by both individuals and partners predicted depressive symptoms, and for women, interactions also emerged between their own and their partners' coping. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

When Grades Determine Self-Worth: Consequences of Contingent Self-Worth for Male and Female Engineering and Psychology Majors.

The impact of grades on daily self-esteem, affect, and identification with major was examined in a sample of 122 male and female students majoring in engineering and psychology. Self-esteem, affect, and identification with major increased on days students received good grades and decreased on days they received poor grades: basing self-esteem on academic competence moderated the effect of bad grades. Bad grades led to greater drops in self-esteem but not more disidentification with the major for women in engineering. Instability of self-esteem predicted increases in depressive symptoms for students initially more depressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)