Consecutive Aromatic Residues Are Required for Improved Efficacy of β-Sheet Breakers

Alzheimer’s disease is a fatal neurodegenerative malady which up to very recently did not have approved therapy modifying its course. After controversial approval of aducanumab (monoclonal antibody clearing β-amyloid plaques) by FDA for use in very early stages of disease, possibly new avenue opened for the treatment of patients. In line with this approach is search for compounds blocking aggregation into amyloid oligomers subsequently forming fibrils or compounds helping in getting rid of plaques formed by β-amyloid fibrils. Here we present in silico work on 627 sixtapeptide β-sheet breakers (BSBs) containing consecutive three aromatic residues. Three of these BSBs caused dissociation of one or two β-amyloid chains from U-shaped β-amyloid protofibril model 2BEG after docking and subsequent molecular dynamics simulations. Thorough analysis of our results let us postulate that the first steps of binding these successful BSBs involve π–π interactions with stacked chains of F19 and later also with F20 (F3 and F4 in 2BEG model of protofibril). The consecutive location of aromatic residues in BSBs makes them more attractive for chains of stacked F3 and F4 within the 2BEG model. Spotted by us, BSBs may be prospective lead compounds for an anti-Alzheimer’s therapy.     

超、高超声速大长细比飞行器气动特性快速计算

将牛顿碰撞类方法推广应用于超、高超声速细长体导弹的气动特性预测.根据飞行器的外形特征,将外形分成几个部分,根据各自几何特点和流场特性,对不同部分及其迎风面和背风面选用不同的方法,计算方法适用于Ma=3~25、攻角0~30°范围内大长细比导弹类飞行器的气动力特性快速计算.经过与风洞试验数据的对比,证明此方法具有计算速度快、精度高的特点.     

新型小径深井救捞装置

此种小径深井救捞装置运用凸轮轨迹控制原理实现托爪(托捞部件)的顺利转起、放下与固定,操作简便,功能可靠,节能环保,是理想的小径深井救捞装置.该装置也可用于矿井、峡谷、墙(楼)缝、冰窟等条件下的救捞.     

青菜冲中磷矿压的分析与控制

对开阳磷矿马路坪矿段延伸开采工程中采用新型锚杆护顶房柱法出现的地压显现问题进行了详细的分析 ,并提出了地压控制措施。     

四合一天线合路器的控制与实现

介绍了一种基于FPGA控制的四合一天线合路器,该合路器能够根据4部电台的不同频率选择正确的通信信道,并将其信息传送到一路天线上进行通信。文中介绍了该合路器的硬件结构,软件控制算法以及工程上的实现方法。测试表明,该天线合路器能够满足4部电台同时在一路天线上进行接收与发送的要求,具有广泛的实用价值。     

矿物绝缘电缆铜带纵包氩弧焊焊接连续轧制生产工艺

简述了矿物绝缘电缆铜带纵包氩弧焊焊接连续轧制的生产工艺,并对该生产工艺中可加硅油氧化镁粉运用、定芯管的设计、氩弧焊焊接、轧辊轧制以及中频感应退火作了描述,同时对连续生产过程中相关工艺作了说明。     

检定S型短型热电偶的4种不同冷端补偿方法之比较

检定长度在200～700 mm范围内的S型热电偶时,由于参考端温度大都处于室温或者波动的温场之中,需要将参考端温度恒定在0℃或采取修正、补偿等措施进行修正。现采取检定中最常用的4种不同的冷端补偿方法检定同一支S型短型热电偶,对结果进行比较分析,得到这4种不同的冷端补偿方法的优劣性及其准确度排序。结果表明,将参考端应用达到一等标准热电偶准确度水平的同极性热电偶丝延伸至参考端恒温器方法能获得较为理想的补偿效果。     

Low cost high sensitivity dynamometer

This paper concerns the dynamometer with magnetoelectric actuator. Its construction and functionality were described. The conducted tests allow to estimate a number of metrological parameters of the dynamometer. Several practical applications together with their results were shown.     

Comparing true and false confessions among persons with serious mental illness.

Over the past decade, knowledge on false confessions has grown tremendously. However, a similar knowledge base on true confessions has not. In the present study, independent, self-reported true and false confession experiences of persons with serious mental illness were compared. In addition to examining the crimes and police questioning that led to the true or false confession, we investigated the reasons behind the confessions and the eventual case outcomes. We found that, in comparison to true confessors (n = 30), false confessors (n = 35) were questioned more times, took longer to confess, perceived the evidence against them to be weaker, and reported significantly more external pressure and less internal pressure. Moreover, of those participants who were convicted, false confessors were four times more likely to receive a prison sentence than true confessors. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

运用带压堵漏技术解决设备维修难题

介绍了带压密封堵漏技术原理,通过实例,介绍了带压密封堵漏技术在生产中的应用情况及效果。实践证明合理使用带压密封堵漏技术,可成功解决和处理生产装置和设备、管道出现的多种泄漏。