An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA

Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan sulfate glycosaminoglycan (HS GAG) and its accumulation in tissues. MPS IIIA represents a significant proportion of childhood dementias. This condition generally leads to patient death in the teenage years, yet no effective therapy exists for MPS IIIA and a complete understanding of the mechanisms of MPS IIIA pathogenesis is lacking. Here, we employ targeted CRISPR/Cas9 mutagenesis to generate a model of MPS IIIA in the zebrafish, a model organism with strong genetic tractability and amenity for high-throughput screening. The sgsh^Δex5−6 zebrafish mutant exhibits a complete absence of Sgsh enzymatic activity, leading to progressive accumulation of HS degradation products with age. sgsh^Δex5−6 zebrafish faithfully recapitulate diverse CNS-specific features of MPS IIIA, including neuronal lysosomal overabundance, complex behavioural phenotypes, and profound, lifelong neuroinflammation. We further demonstrate that neuroinflammation in sgsh^Δex5−6 zebrafish is largely dependent on interleukin-1β and can be attenuated via the pharmacological inhibition of Caspase-1, which partially rescues behavioural abnormalities in sgsh^Δex5−6 mutant larvae in a context-dependent manner. We expect the sgsh^Δex5−6 zebrafish mutant to be a valuable resource in gaining a better understanding of MPS IIIA pathobiology towards the development of timely and effective therapeutic interventions.     

轧辊光纤激光无序毛化技术:无序毛化的应用(下篇)

在连轧机、平整机、光整机上对光纤激光无序毛化轧辊与电火花毛化轧辊的过钢量,粗糙度R_a和R_(pc)值随过钢量的变化进行了对比;同时,对光纤激光无序毛化轧辊R_a=2.0~5.0μm范围内与R_(pc)值的关联情况进行了研究。结果表明:光纤激光无序毛化轧辊适用于连轧、平整、光整等工艺,其R_(pc)值高于电火花毛化辊,且R_a与R_(pc)的关联度较弱。     

建筑防火与安全的标本兼治与综合治理

通过对国内外建筑节能中外墙外保温系统存在的防火安全问题的分析,从标准、规范、政策、监管及市场等方面论述了中国要完成＂十二五＂规划中提出的建筑节能总目标,在现阶段只能采用国内外通用的高效节能泡沫（EPS、XPS、PU）作主体保温材料。结合杨宗焜教授专家团队采用的化学结构改性技术,对走无卤化、结碳膨胀型难燃化技术路线研制的火焰传播性小,烟雾少、毒性小、耐燃性好,火焰贯穿强的难燃化的新型PU泡沫的技术特点、成果应用等进行了阐述,提出中国应结合国外发达国家相关规范及标准,尽快建立并完善中国式建筑节能保温系统中的防火安全技术标准,规范划分防火安全耐火性等级及市场规范,并最终实现标本兼治、综合治理的建筑防火安全目标。     

Neurofeedback Treatment of College Students' Test on Anxiety, Depression, Personality, and Mood

Biofeedback is used to treat the mental diseases of college students, such as test anxiety, depression, personality, and mood. Anxiety of the colleague students was first tested by test anxiety scale （TAS） and then treated by biofeedback. After getting the biofeedback treatment, the students＇ TAS scores, blood volume pulse, and skin conductance were decreased, especially, their TAS scores dropped markedly. Meanwhile, the level of EEG （61 rhythm/a rhythm） and peripheral temperature increased observably. Then, neurofeedbaek （β1 rhythm/α rhythm） was applied to treat students＇ depression, personality, and mood. As a result, these three kinds of symptoms got alleviated. And their therapeutic effects based on neurofeedback were more stable, durative and less reerudescent.     

Underdiagnosing and nontreatment of posttraumatic stress disorder in community mental health: A case study.

Research indicates that trauma is extremely prevalent among populations seeking community-based services. However, underdiagnosis and nontreatment of trauma-related disorders is widespread. This study explored how one urban community mental health center (CMHC), serving a severely mentally ill (SMI) population, assessed, diagnosed, and treated reported trauma histories. Results indicate that of the 72 consumers in this sample who reported trauma histories (51%), only 2 were diagnosed with posttraumatic stress disorder (PTSD). Instead, those with a reported trauma history were likely to be diagnosed with affective disorders and were almost seven times as likely to be recommended therapy as were those without a trauma history. However, even those recommended therapy were not likely to receive it. Findings indicate significant barriers to PTSD diagnoses and the receipt of therapy services. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stigma and barriers to care in soldiers postcombat.

The present study examined the effects of leadership and unit cohesion on mental health stigma and perceived barriers to care. A sample of 680 soldiers from combat support units were surveyed 3 months after their return from combat operations in Iraq. The survey included scales on psychological symptoms and perceptions of leader behaviors and unit cohesion, as well as items assessing stigma and barriers to care. The sample was used to test the independent and interactive effects of leadership and unit cohesion on soldiers’ perceptions of stigma and barriers to care. Analyses yielded significant interaction effects between leadership and cohesion in predicting stigma and barriers to care, while controlling for the effects of mental health symptoms. Soldiers who rated their leaders more highly and who reported higher unit cohesion also reported lower scores on both stigma and perceived barriers to care. Thus, positive leadership and unit cohesion can reduce perceptions of stigma and barriers to care, even after accounting for the relationship between mental health symptoms and these outcomes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personal intelligence expressed: A theoretical analysis.

An individual's cumulative life decisions help determine that person's well-being. To make good decisions requires knowing something about who one is and who one wants to be. It seems plausible that personality may draw on a specifically tailored intelligence that supports its own self-understanding and contributes to such life decisions. This personal intelligence (PI) helps the individual meet his or her own personal needs and to fit in with (or stand out from) the environment. What are people high in PI actually like relative to those lower in the skills? Drawing on a 2008 theory of PI-related abilities, the author reviews several literatures to examine what features distinguish the behavior of people high in PI from those lower in such skills. The feature list sets the stage for future research in distinguishing high-PI individuals from low-PI individuals according to their life expressions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predicting post-treatment-initiation alcohol use among patients with severe mental illness and alcohol use disorders.

Few investigators studying alcohol abuse among individuals with a severe mental illness (SMI) have examined predictors of posttreatment alcohol outcomes. In the present study, a multivariate approach based on a theoretical model was used to study the relationship between psychosocial factors and post-treatment-initiation alcohol use. Predictors of alcohol use outcomes were examined in 278 individuals diagnosed with a current schizophrenia-spectrum or bipolar disorder and an alcohol use disorder (AUD). At 6-months follow-up, 144 of 228 available participants (63%) had good clinical outcomes. The results of structural equation modeling indicated that type of pretreatment residential setting was directly related to treatment, with participants who lived in supervised settings (41%) reporting significantly more days of treatment (β = .34, p     

Reduced specificity of autobiographical memory in Cluster C personality disorders and the role of depression, worry, and experiential avoidance.

The study objective was to investigate whether, compared with nonclinical controls, participants with an avoidant, dependent, or obsessive–compulsive Cluster C personality disorder (PD) manifested reduced levels of memory specificity and whether the association of Cluster C PDs with memory specificity is mediated by repetitive negative thoughts and experiential avoidance. The Autobiographical Memory Test (R. J. McNally, N. B. Lasko, M. L. Macklin, & R. K. Pitman, 1995) was administered along with self-report measures (translated into Dutch) for repetitive, uncontrollable, and negative thinking in the form of worry (Penn State Worry Questionnaire; T. J. Meyer, M. L. Miller, R. L. Metzger, & T. D. Borkovec, 1990) and experiential avoidance (Acceptance and Action Questionnaire; S. C. Hayes et al., 2004) to 294 clinical participants diagnosed with Axis I disorders (assessed with the Structured Clinical Interview for DSM–IV Axis I Disorders [SCID-I]; M. B. First, R. L. Spitzer, M. Gibbon, & J. B. W. Williams, 1994) and Axis II disorders (assessed with the SCID-II; M. B. First, R. L. Spitzer, M. Gibbon, & J. B. W. Williams, 1997)—202 with avoidant, 49 with dependent, and 120 with obsessive–compulsive PD—and to 108 matched nonclinical controls. Participants with a Cluster C PD showed lower levels of memory specificity than did nonclinical controls. Depression and worry mediated the effect of Cluster C PDs on memory specificity. Besides depression severity, repetitive, uncontrollable, and negative thinking may constitute a general mechanism mediating the association of various Axis I and II disorders with memory specificity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Preferences for ancient and modern art museums: Visitor experiences and personality characteristics.

This research has two main purposes. The first is to replicate and possibly to extend the results obtained in a previous study, where the authors found that visitors to the ancient art museum conducted their visit with the primary aim of acquiring understanding and knowledge, while modern art museum visitors conducted their visit with an approach that was primarily emotional and pleasure-seeking. The second purpose relates to studies showing that people who prefer abstract art present higher levels on personality traits like “Openness to Experience” and “Sensation Seeking,” compared to people who prefer realistic art. This study investigates these two personality traits for people who favor visiting museums of ancient rather than modern art. Results confirmed previous findings that emotional aspects related to the visit were relevant for modern art museum visitors, while a more cognitive approach based on learning characterized ancient art museum visitors. Concerning personality traits, no difference was found between the two museum groups on the “Openness to Experience” dimension; differences were found on the “Sensation Seeking” trait; modern art museum visitors attained higher scores as compared to ancient art museum visitors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)