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391.
    
Due to its high lethality among older people, the safety of nursing homes has been of central importance during the COVID-19 pandemic. With test procedures and vaccines becoming available at scale, nursing homes might relax prohibitory measures while controlling the spread of infections. By control we mean that each index case infects less than one other person on average. Here, we develop an agent-based epidemiological model for the spread of SARS-CoV-2 calibrated to Austrian nursing homes to identify optimal prevention strategies. We find that the effectiveness of mitigation testing depends critically on test turnover time (time until test result), the detection threshold of tests and mitigation testing frequencies. Under realistic conditions and in absence of vaccinations, we find that mitigation testing of employees only might be sufficient to control outbreaks if tests have low turnover times and detection thresholds. If vaccines that are 60% effective against high viral load and transmission are available, control is achieved if 80% or more of the residents are vaccinated, even without mitigation testing and if residents are allowed to have visitors. Since these results strongly depend on vaccine efficacy against infection, retention of testing infrastructures, regular testing and sequencing of virus genomes is advised to enable early identification of new variants of concern.  相似文献   
392.
《工程(英文)》2021,7(7):936-947
Coronavirus disease 2019 (COVID-19) deaths per million population in the countries of the West had often exceeded those in the countries of the East by factor of 100 by May 2021. In this paper, we refer to the West as represented by the United States plus the five most populous countries of Western Europe (France, Germany, Italy, Spain, and the United Kingdom), and the East as the 15 countries in East Asia and Oceania that are members of the Regional Comprehensive Economic Partnership, RCEP (Australia, Brunei, Cambodia, China, Indonesia, Japan, the Republic of Korea, Laos, Malaysia, Myanmar, New Zealand, Philippines, Singapore, Thailand, and Vietnam). This paper argues that currently available information points to the factors most responsible for the East–West divide. Warnings by early January 2020 about an atypical viral pneumonia in Wuhan, China, prompted rapid responses in many jurisdictions in East Asia. Publication of the virus’s genome on 10 January 2020 provided essential information for making diagnostic tests and launching vaccine development. China’s lockdown of Wuhan on 23 January 2020 provided a final, decisive signal of the danger of the new disease. By late March 2020, China had fully controlled its epidemic, and many other RCEP countries had taken early and decisive measures, including restrictions on travel, that aborted serious outcomes. Inaction during the critical month of February 2020 in the United States and most other Western countries allowed the disease to take hold and spread. In both the East and the West, stringent population-wide non-pharmaceutical interventions were widely implemented at great cost to societies, economies, and school systems. Without these measures, the outcomes could have been even worse. Most countries in the East also implemented tightly focused policies to isolate infectious individuals. Even today, most countries in the West allow infectious individuals to mingle with their families, coworkers, and communities. Much of the East–West divide plausibly results from failure in the West to implement the basic public health policies of early action and the isolation of infectious individuals. Widespread immunization in some RCEP and high-income countries will soon attenuate their outbreaks, while the slow rollout of vaccines in lower income countries is replacing the East–West divide in outcomes with a North–South one. The South is thus replacing the West as the breeding ground for more dangerous variants as exemplified by the highly contagious Delta variant, which may undermine hitherto successful control strategies in many countries.  相似文献   
393.
    
Color therapy, healing through color, supposedly works through the physical exposure to color. In two studies, we assessed stress and anxiety reduction after color exposure using a commercially available relaxation-through-color routine. Participants either completed the routine by looking at the accompanying color disks or at a white patch. In study 1 (longitudinal), 60 participants completed the routine three times, each testing session separated by a week. In study 2 (cross-sectional), 63 participants completed half of the trials once. In both studies, we recorded a decrease in stress and anxiety levels comparing before-after scores. In study 1, we recorded incremental decreases with each week. Crucially, decreases were the same whether participants (a) physically saw colors or not, and (b) completed the full or shortened version. We conclude that other factors but physical exposure to color explain changes in affective states associated with this and probably other color therapy routines.  相似文献   
394.
    
This study examines the effectiveness of a short-term instructional intervention in the school context. The aim was to provide students with essential declarative knowledge on what to consider when evaluating the authoritativeness of Web sources, and the accuracy of their information. It also provided the opportunity to apply this declarative knowledge in a basic inquiry task on the controversial topic of the possible harm caused by mobile phones. Participants were 134 ninth graders, randomly assigned to the instruction or no-instruction condition. In both conditions the same multiple Internet sources, varying for authoritativeness and stance, were given for the basic and transfer (about GM food) inquiry tasks. Findings reveal that learners in the instruction condition outperformed the others in both the inquiry task of the instructional context and, more importantly, in the transfer inquiry task. These learners showed more appropriate navigation behavior and greater source evaluation, as well as better surface and deeper comprehension of the accessed information on GM food. In addition, prior knowledge moderated the latter. Theoretical and practical significance of the study is outlined.  相似文献   
395.
Mobbing and bullying are forms of abusiveness that are of increasing concerns in the workplace. This special issue overviews various issues and interventions relevant for the practice of consulting psychology. The articles describe theoretical issues including prevalence, definitional clarity, and the influence of individual, work group, and organizational dynamics; they also describe various organizational interventions, including alternative dispute resolution, antimobbing training, and antibullying policy development. These articles and commentaries are intended to inform, provide strategies, and foster discussion of how consulting psychologists can best serve clients and client organizations that are experiencing mobbing and bullying. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
396.
使用抗氧剂清除活性氧(ROS)被证实是应对经皮冠状动脉介入治疗(PCI)相关并发症的有效方法,但抗氧剂向特定组织的长期局部输送不易实现.本文将抗氧剂TEMPOL可控地负载入静电纺丝纳米纤维以实现其局部应用和长期抗自由基能力,制得TEMPOL负载薄膜的生物功能通过细胞增殖、ROS清除能力、单核细胞黏附、细胞迁移、炎症因子...  相似文献   
397.
The Igbos are one of the major tribes of Nigeria. Over the years, their distinct way of living have further accentuated their culture. The paper discusses the Igbo cultural landscape region which comprises of rural autonomous communities made up of clusters of kindred and villages. In spite of the existence of the townships serving as trade, political and administrative centers for more than one century, the rate of urbanization has been very slow thereby affecting the development of the communities physically, economically and socially at astonishing rates consuming farmlands and traditional community boundaries. This paper is aimed at creating awareness on the unique regional growth pattern in Igbo land heavily dependent on cultural and natural heritages for purpose of determining adaptable regional planning strategies for such vibrant cultural region. It has examined the key issues and suggested a way forward to a more sustainable development of the region.  相似文献   
398.
    
Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical, mechanical, and lifestyle factors. Moreover, an inadequate nutritional status, such as low intake of protein, vitamin D, and calcium, and a reduction in physical activity are key risk factors for OS. This review aims to increase knowledge about diagnosis, incidence, etiology, and treatment of OS through clinical studies that treat OS as a single disease. Clinical studies show the relationship between OS and the risk of frailty, falls, and fractures and some association with Non-communicable diseases (NCDs) pathologies such as diabetes, obesity, and cardiovascular disease. In some cases, the importance of deepening the related mechanisms is emphasized. Physical exercise with adequate nutrition and nutritional supplementations such as proteins, Vitamin D, or calcium, represent a significant strategy for breaking OS. In addition, pharmacological interventions may confer benefits on muscle and bone health. Both non-pharmacological and pharmacological interventions require additional randomized controlled trials (RCT) in humans to deepen the synergistic effect of exercise, nutritional interventions, and drug compounds in osteosarcopenia.  相似文献   
399.
李超  覃飙 《计算机科学》2022,49(1):279-284
在因果网中,对和积问题因果效果的计算是其首要问题,从有向无环图的角度,研究者们发现每一个因果网都有一个与之对应的贝叶斯网络,干预是因果网的一个基本操作.类似于贝叶斯网络中的剪枝策略,在剪枝掉所有无效结点后,文中设计了一种优化的算法OFDo来计算对因果网中每个结点的完全原子干预.文中接着研究多干预操作,发现多干预操作具有...  相似文献   
400.
In medicine, inflammation is a fuzzy, overused word first coined by the Romans, the intended meaning and precise definition of which varies according to the person and the clinical context. It tends to carry a negative connotation as a response gone awry, like a raging, out-of-control wildfire that requires immediate control and containment lest it destroy all in its path; however, frequently overlooked or lost in the shuffle is the primordial importance of inflammation to health and survival. The precise definition of inflammation matters for several reasons, not least because of the over-liberal use of anti-inflammatory drugs to inhibit inflammation, which may, contrary to prevailing dogma that all inflammation is harmful, act counterproductively to prevent restitutio ad integrum. Using fire as a central analogy, this overview attempts to define inflammation, the better to determine how to manage it, i.e., whether to fan its flames, let it burn out, or suppress it entirely.  相似文献   
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