Effect of relative humidity on the store stability of spray-dried beta-carotene nanoemulsions

In order to overcome the limitations of liquid-base emulsion system, beta-carotene nanoemulsions stabilized by modified starch were spray-dried to powders after the emulsification process. The powders showed a good dissolution in water and the reconstituted emulsions had similar particle sizes with the fresh nanoemulsions. A 30 days storage test was carried out to investigate the effect of relative humility (RH) on the storage stability of beta-carotene powders at 25.0 °C. The beta-carotene degradation profiles over time were found to fit well with a Weibull model and also closely related to the film property of the matrix, moisture sorption property and glass transition temperature of the powder. The results showed that modified starches with lower film oxygen permeability had a higher retention of beta-carotene during storage. The glass transition temperature of powder in different RH also affected the rate of beta-carotene degradation. Overall these results provide useful information for choosing wall materials and storage conditions to protect nutraceuticals in delivery systems.     

塑料三通管挤胀成型过程的运动学研究

通过对三通管挤胀成型过程中的不同变形部位进行分区建立坐标系，确定了不同区域内材料塑料性流动的速度场分布。     

引导型创新实验的构建与实现

本文研究大学计算机基础课程的主要实验类型及特点,基于自主设计与创新型实验方法构建引导型创新实验模型,并给出具体实现方案,以弥补自主设计与创新实验缺乏指导作用、不易管理的缺点。     

双金属板渐进成形底部鼓包和侧壁鼓凸研究

为了从工艺上提高双金属板成形精度,通过实验结合有限元分析的方法探究了不同工艺参数对成形精度的影响,研究表明:成形角度和成形深度分别是影响底部精度和侧壁精度的最关键因素,当成形角度由30°增大至60°时,底部鼓包高度降低29%,侧壁鼓凸量增加18.5%;当工具头直径由10 mm增大至20 mm时,底部鼓包高度下降13%,侧壁鼓凸量下降16%;当下压量由0.5 mm减小至0.2 mm时,底部鼓包高度下降24%,侧壁鼓凸量增加18.3%;最后优选了合理的工艺参数,使得底面鼓包高度下降49%,侧壁鼓凸量下降41%。     

基于综合评价的SiCp/Al磨削表面质量试验

目的 针对高体积分数SiCp/Al加工表面缺陷复杂多样,提出其表面质量综合评价方法,研究磨削参数对SiCp/Al磨削表面质量的耦合影响规律,优化加工工艺.方法 基于SiCp/Al磨削加工表面缺陷,提出粗糙度综合指标SR为主、表面形貌为辅的表面质量综合评价方法,采用全因子试验方法分析低、高进给速度工况下主轴转速和磨削深度对表面质量的影响规律.借助Abaqus软件揭示SiCp/Al磨削表面形成机理,解释试验结果.结果 小切深(ap为5μm和20μm)时,粗糙度综合指标SR随着主轴转速ns的增加而先递减再增大;大切深(ap为40μm和80μm)时,SR随着ns的递增而递减或近似递减.低主轴转速(ns为2000 r/min和4000 r/min)时,SR随着磨削深度ap的增加(ap由5μm递增到80μm)而先增大再减小而后又增加;高主轴转速(ns为6000 r/min和8000 r/min)时,SR随着ap的增加而先增加再低进给量时减小或高进给量时增加.获得最佳磨削表面质量的最优磨削参数是:进给速度vf=50 mm/min,磨削深度ap=5μm,主轴转速ns=6000 r/min.兼顾磨削效率和表面质量的最优磨削参数是:vf=50 mm/min,ap=80μm,ns=8000 r/min.结论 表面质量综合评价方法的可靠性较高,主轴转速和磨削深度对表面质量的影响具有耦合性,减小磨削深度、采用适当主轴转速有助于改善表面质量.     

LC移相电路在调频和鉴频中的应用与仿真

由LC回路构成的移相电路具有调节输入输出信号之间的相位关系的作用,在通信电路中有广泛的应用。为深入研究LC移相电路的应用原理,论文推导了LC移相电路的传递函数,分析相移与电路参数的关系,讨论移相电路在间接调频和正交鉴频电路中的作用。利用Multisim仿真软件分别对调频和鉴频电路进行了仿真实验并验证理论分析结果,在通信电路课程学习中有助于学生加深对这部分知识的理解和掌握,提高应用能力。     

Multicomponent gas diffusion in nonuniform tubes

In many technical processes gas, multicomponent diffusion takes place in confinements that are rarely uniform in direction of their long axis (e.g., catalysts pores). Here, we show that in conical tubes multicomponent diffusion is hindered. This effect increases with ratio of inlet to outlet cone radius Λ, indifferent of the orientation of the tube. Based on the Maxwell–Stefan equations, predictive analytical solution for ideal multicomponent diffusion in slightly tapered ducts is developed. In two‐bulb diffusion experiments on a uniform tube, the results of Duncan and Toor (1962) were reproduced. Comparison of model and experiment shows that the solution presented here provides a reliable quantitative prediction of the temporal change of H₂, N₂, and CO₂‐concentration for both tube geometries, uniform and slightly conical. In the demonstrated case (Λ = 3.16), mass diffusion is 68% delayed. Thus, for gaseous diffusion in “real,” typically tapered pores the transport limitation is more serious than considered so far. © 2014 American Institute of Chemical Engineers AIChE J, 61: 1404–1412, 2015     

飞机电源系统综合实验平台设计与实现

针对军用飞机电源系统种类多,为保证在一种实验平台上实现多种电源装备的实验训练,满足机务维护人员能力培训的要求,研究设计了飞机电源系统综合实验平台。实验平台采用综合化、通用化的设计思路,综合运用计算机测控、虚拟仪器等现代测试技术,可实现飞机主电源系统、二次电源、控制保护类附件的性能测试实验,并具备新型设备的拓展实验能力。通过开展实验教学,证明该实验平台功能完善,性能稳定,设计方案合理,能够满足飞机电源系统通用性实验要求,具有很强的推广应用价值。     

复合材料双极板配方优化研究

将碳纤维(CF)、碳纳米管(CNT)、乙炔黑(AB)和炭黑(CB)等导电材料与丙烯腈-丁二烯-苯乙烯(ABS)塑料混合,压制成复合材料导电双极板基体,再在两侧覆盖铅箔,得到双极板。观察基体成型后的外观,并测试导电性能。正交实验确定复合材料双极板的优化配方为:m(ABS)∶m(CF)∶m(CNT)∶m(AB)∶m(CB)=100∶1∶0.5∶6∶8。以此配方制作的24 V、10 Ah双极性铅酸电池与传统单极电池相比,内阻低28%,以0.5 Ca放电,比能量高15%左右。     

Development and evaluation of orally disintegrating tablets of cilostazol-β-cyclodextrin inclusion complexes

Context: The clinical applications of cilostazol (CLZ) are limited by its low aqueous solubility (<5?µg/ml) and high biovariability.

Objective: The aim of this study was to enhance the solubility of CLZ by forming inclusion complexes (ICs) with beta cyclodextrin (β-CD) and formulating them into oral disintegrating tablets.

Methods: Phase solubility study of CLZ with β-CD was performed in water. Job’s plot was constructed to determine the stoichiometry of ICs. ICs, prepared by spray-drying technique, were characterized using Fourier transform infrared spectroscopy, differential scanning calorimetry, hot stage microscopy, powder X-ray diffraction and nuclear magnetic resonance. Molecular modeling studies were performed to understand the mode of interaction of CLZ with β-CD. The formulation process was undertaken using a reproducible design of experiment generated model, attained by variation of diluents and disintegrants at three levels. Tablets were evaluated for drug content, hardness, friability, disintegration time (DT), wetting time (WT) and dissolution profiles.

Results and discussion: Phase solubility studies suggested an A_L type curve with stability constant (K_s) of 922.52?M^?1. Job’s plot revealed 1:2 stoichiometry. All analytical techniques confirmed inclusion complexation. Molecular modeling revealed dispersive van der Waals interaction energy as a major contributor for stabilization of complex. The spray-dried complexes showed higher solubility and faster dissolution compared to plain CLZ. The optimized formulation showed DT of 11.1?±?0.8?s, WT of 8.7?±?0.9?s and almost complete dissolution of CLZ in 15?min.

Conclusion: The prepared tablets with low DT and fast dissolution will prove to be a promising drug delivery system with improved bioavailability and better patient compliance.