3D registration of human face using evolutionary computation and Kriging interpolation

This paper proposes a fast and robust 3D human face geometric data registration strategy dedicated for image-guided medical applications. The registration scheme is composed of a coarse transformation stage and a fine-tuning stage. In the first stage, fuzzy c-mean is used to reduce the data amount of template 3D image, and evolutionary computation is implemented to find optimal initial pose for the Iterative Closest Point plus k-dimensional (KD) tree scheme. In the second stage, the huge reference image data are replaced by a Kriging model. The time-consuming search for corresponding points in evaluating the degree of misalignment is substituted by projecting the points in the template image onto the model. To illustrate the validity and applicability of the proposed approach, a problem composed of 174 635 points reference image and an 11 280 points template image is demonstrated. Computational results show that our approach accelerates the registration process from 1361.28 seconds to 432.85 seconds when compared with the conventional ICP plus K-D tree scheme, while the average misalignment reduces from 11.35 mm to 2.33 mm. This work was presented in part at the 13th International Symposium on Artificial Life and Robotics, Oita, Japan, January 31–February 2, 2008     

Subacute proteome changes following traumatic injury of the developing brain: Implications for a dysregulation of neuronal migration and neurite arborization

Traumatic brain injury (TBI) is a major cause of morbidity and mortality among children and adolescents. To gain insight into developmental events influenced by TBI, we analyzed subacute mouse brain proteome changes in a percussion head trauma model at P7 ipsi- and contralateral to the site of injury. The comparison of brain proteomes of trauma mice and controls revealed reproducible changes in the intensity of 28 proteins (30 protein spots) in response to trauma. The changes detected suggest that TBI leads to apoptosis, inflammation, and oxidative stress. These changes were consistent with our results of histological and biochemical evaluation of the brains which revealed widespread apoptotic neurodegeneration, microglia activation, and increased levels of protein carbonyls. Furthermore, we detected changes in proteins involved in neuronal migration as well as axonal and dendritic growth and guidance, suggesting interference of trauma with these developmental events.     

1993: Axline's eight principles of play therapy revisited.

Examined V. Axlines's book, Play Therapy (1947) which includes 8 basic principles on non-directive play therapy. Student responses to learning these principles in play therapy classes were also examined. Each student was assigned a play therapy client and was observed and assisted directly by the instructor, a licensed clinical psychologist. Clients were mildly trouble children (aged 5–10 yrs) and were selected from a referral base by the instructor as appropriate for the course. As the semester progressed and students gained direct experience, weekly small (3–4 student) group discussions were held to explore in-depth understanding of play therapy principles and how these principles are put into practice. It is concluded that Axline's book remains a classic text and a foremost resource in the field. Coupling it with experiential learning is an invaluable basis for teaching play therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychophysical studies of repetitive wrist flexion and extension

Abstract

The purpose of this experiment was to investigate the feasibility of using psychophysical methods to determine maximum acceptable forces for various types and frequencies of repetitive wrist motion. Four adjustable work stations were built to simulate repetitive wrist flexion with a power grip, wrist flexion with a pinch grip, and wrist extension with a power grip. The study consisted of two separate experiments. Subjects worked for two days per week during the first experiment, and five days per week during the second experiment. Fifteen women completed the first experiment, working seven hours each day, two days per week, for 20 days. Repetition rates of 2, 5, 10, 15 and 20 motions per minute were used with each flexion and extension task. Maximum acceptable torques were determined for the various motions, grips, and repetition rates without dramatic changes in wrist strength, tactile sensitivity, or number of symptoms. Fourteen different women completed the second experiment, performing a wrist flexion motion (power grip) fifteen times per minute, seven hours per day, five days per week, for 23 days. There were no significant differences in maximum acceptable torque from day to day. However, the average maximum acceptable torque for a five days per week exposure was 36-3% lower than for the same task performed two days per week. Assuming that maximum acceptable torques decrease 36-3% for other repetition rates and motions, tables of maximum acceptable force were developed for female wrist flexion (power grip), female wrist flexion (pinch grip), and female wrist extension (power grip).     

HSV-tk基因/GCV系统治疗肿瘤的旁观者效应与缝隙连接关系的研究

目的 探讨单纯疱疹病毒胸苷激酶（HSV－tk）基因／丙氧鸟苷（GCV）系统杀伤肿瘤细胞时旁观者效应与细胞间缝隙连接的关系。方法 用PA317细胞包装STK质粒（逆转录病毒载体介导的HSV-tk基因），形成假逆转录病毒颗粒，转染有缝隙连接的大鼠胶质瘤细胞C6和无缝隙连接的入宫颈癌细胞 Hela，制成 C6 tk+和 Helatk+细胞，将不同比例的C6和 C6 tk+、Hela和 Hela tk+细胞混合，每种比例8孔，培养 24h后 4孔加入含0．5μg/mlGCV的培养基，4孔作对照，6d后用MTT法测量细胞存活率。在两个培养皿中放入周围粘有33mm高滤纸的载玻片，分别接种 C6、C6 tk+细胞。细胞 80%汇合后将载玻片互换，并加入含0．5μg/ml GCV的培养基，6d后观察细胞形态。结果C6细胞组存在旁观者效应，Heal细胞组不存在旁观者效应。培养皿中tk+细胞大部分被杀死,tk-细胞无变化。结论HSV-tk基因/GCV系统杀伤肿瘤细胞时旁观者效应与细胞间缝隙连接有关。     

Physical, Mental, and Social Catastrophic Cognitions as Prognostic Factors in Cognitive-Behavioral and Pharmacological Treatments for Panic Disorder.

The authors explored the prognostic value of 3 different types of catastrophic cognitions in the treatment of panic disorder with and without mild-to-moderate agoraphobia using a sample of 143 participants who received either cognitive-behavioral therapy (CBT) or imipramine in a randomized controlled trial. Stronger fears of social catastrophes both prior to and following treatment with CBT or imipramine were associated with a poorer outcome. In contrast, cognitions involving physical or mental catastrophes were unrelated to outcome, regardless of whether these thoughts were measured prior to or following treatment. These findings are consistent with the notion that although the intensity of physical catastrophe cognitions may best discriminate between panic disorder and other anxiety disorders, it is the intensity of social catastrophe cognitions that is most closely tied to success in treating this disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Practice Makes Progress? Homework Assignments and Outcome in Treatment of Cocaine Dependence.

The relationship between treatment outcome and the extent to which participants completed homework assignments was evaluated among 60 cocaine-dependent individuals assigned to cognitive-behavioral therapy (CBT). Homework was assigned in 72% of all sessions and initiated by participants in 48% of the sessions in which it was assigned. Completion of homework was unrelated to participants' baseline characteristics and several indicators of treatment compliance. Participants who completed more homework assignments demonstrated significantly greater increases in the quantity and quality of their coping skills and used significantly less cocaine during treatment and through a 1-year follow-up. These data suggest that the extent to which participants are willing to complete extrasession assignments may be an important mediator of response to CBT. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Infidelity in Couples Seeking Marital Therapy.

The revelation of an affair is often an emotionally explosive event for a couple, yet little is known about specific individual and relationship factors that accompany infidelity. The present study examined the qualities of individuals and couples that differentiate couples with (n = 19) and without (n = 115) infidelity using couples from a randomized clinical trial of marital therapy. Findings indicated that couples with infidelity showed greater marital instability, dishonesty, arguments about trust, narcissism, and time spent apart. Gender also proved to be a significant moderator of several effects. Men who had participated in affairs showed increased substance use, were older, and were more sexually dissatisfied. Results offer initial clues to concomitants of affairs for couple therapists. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Stress and Coping Model of Medication Adherence and Viral Load in HIV-Positive Men and Women on Highly Active Antiretroviral Therapy (HAART).

The authors tested a structural model that incorporated age, time since diagnosis, social support, coping, and negative mood as predictors of medication adherence and HIV viral load on 188 men and 134 women on highly active antiretroviral therapy (HAART). The authors used psychosocial latent factors formed from baseline measures to predict latent factors of adherence, as assessed by electronic monitoring and self-report, and viral load defined by indicators assessed over a 15-month period. Results from the model indicate that greater negative mood and lower social support are related to greater use of avoidance-oriented coping strategies. Use of these coping strategies by patients on HAART is related to poorer medication adherence and, subsequently, higher viral load. This model advances researchers' understanding of the contribution of psychosocial variables in predicting treatment adherence and disease progression in HIV-positive men and women. (PsycINFO Database Record (c) 2010 APA, all rights reserved)