水合抛光加工的运动学特性

建立了旋摆驱动方式下水合平面抛光过程中工件的运动学模型,揭示了抛光盘开孔方式对蓝宝石衬底的水合抛光均匀性影响规律。旋摆驱动条件下,杉木抛光盘的开孔方式对蓝宝石衬底水合抛光加工全局均匀性和局部均匀性具有重要的作用,局部均匀性的阶梯状分布为直线、圆环和螺旋线开孔方式的共性特征。与直线、圆环开孔方式相比,在一定的参数取值条件下,螺旋线开孔方式可更好地实现水合抛光加工的全局均匀性和局部均匀性要求。     

浅议冲压模具冲裁间隙均匀的装配方法改进

模具冲裁间隙是否均匀是影响模具寿命和冲件质量的关键,也是装配的关键。随着现代加工环境以及制造技术的发展,传统方法与现代模具制造技术已不能相适应。结合传统的装配方法,通过长期的总结,在原来装配理论的基础上介绍一种新的装配方法。     

Comparison of Three Pharmaceutical Products Obtained from Mexico and the United States: A Case Study

ABSTRACT

In recent years, there has been much debate concerning the relative pros and cons of purchasing medications from foreign markets such as Mexico and Canada. The following study compares the content uniformity and weight variation for three medicinal products, acquired from pharmacies in both Mexico and the United States: amoxicillin capsules (500 mg), amoxicillin/clavulanic acid suspension (400 mg and 57 mg/5 mL, respectively), and furosemide tablets (40 mg). Twenty capsules/tablets were individually weighed and a designated aliquot was taken. Following dissolution in an appropriate solvent and sonication, a sample was taken and analyzed via high performance liquid chromatography (HPLC). The suspensions were prepared according to directions on the label. Five samples of the suspensions were then taken and analyzed via an appropriate HPLC method. The content uniformity for the amoxicillin capsules was found to be 15.4 ± 2.4% and 99.4 ± 9.3%, for Mexican and U.S. capsules, respectively. The percent relative standard deviation (% RSD) for weight variation was found to be 8.7% and 1.5% for capsules obtained from Mexico and the United States, respectively. Content uniformity analysis for the Mexican suspension product resulted in an average of 85.5 ± 1.2% for amoxicillin and 98.6 ± 1.9% for the clavulanic acid content, while the results for the U.S. suspension product were 104.4 ± 3.1% and 117.8 ± 3.6% for amoxicillin and clavulanic acid, respectively. Content uniformity for the furosemide tablets was found to be 90.3 ± 4.8% and 95.6 ± 2.1% for Mexican and U.S. tablets, respectively. The % RSD of weight variation for the Mexican tablets was 2.1%, while the % RSD for the U.S. tablets was found to be 1.0%. From the three products tested, content analysis revealed that the amount of active ingredients for two of the products acquired in Mexico were appreciably less than the concentrations for their U.S. counterparts.     

Experimental investigation on the voltage uniformity for a PEMFC stack with different dynamic loading strategies

The operating life of the proton exchange membrane fuel cell stack is mainly decided by performances of its weakest single cell because of the “Buckets effect”, thus high voltage uniformity during a dynamic loading process is key to the stack durability. In this work, a 3-kW stack is examined experimentally on its voltage uniformity (voltage coefficient variation (Cv)) under conditions of loading from open-circuit state (0 A) to nominal current (165 A) and stack temperatures of 30 °C, 45 °C and 65 °C. Different dynamic loading strategies, namely constant loading rate strategy, decreasing loading rate strategy, and increasing loading rate (square/cube increasing loading rate) strategy, are examined and compared. Results display that during the loading process, (a) the voltage uniformity rises abruptly and goes down quickly when the loading current is small (e.g. from 0 A to 22 A), (b) the voltage uniformity under a small loading current is better than that under the open-circuit state, and (c) voltage uniformity decreases as the loading current increases from a small value to the nominal current. Comparisons of different current loading strategies show that as the stack temperature rises from 30 °C to 65 °C, the stack Cv value under the open-circuit state increases from 1.12 to 1.84 and decreases from 3.85 to 2.45 in the nominal current state. The maximum Cv for the decreasing loading rate strategy decreases from 16.25 to 9.49 and that of the constant loading rate strategy also decreases from 5.85 to 4.96. Cv values of the square current increasing loading rate strategy keep below 3.85 under conditions of the three stack temperatures and display a slight fluctuation during the whole current loading process, which indicates that the strategy can effectively make the stack being of an excellent voltage uniformity during the instantaneous response process.     

Study on the uniformity of water film in a transpiring wall reactor for supercritical water oxidation

A three-dimensional computational fluid dynamic model of a transpiring wall reactor for supercritical water oxidation has been built to optimize the uniformity of water film. Results show that the temperature and species distributions at the nozzle outlet deviate from the reactor centre. The inner wall of the porous tube near the transpiring water injection tube displays low temperatures, while high temperatures are recorded far from the injection tube. The circumferential temperature distribution on the inner wall of the porous tube is uneven. This phenomenon is due to the uneven injection of the transpiring water, leading to the uneven protection of the water film and local overheating of the porous wall. The injection velocity of the transpiring water significantly decreases when the number of injection tubes is increased, and the circumferential velocity and temperature distributions on the porous wall gradually become even. Moreover, high pressure drops across the porous wall at low porosities are useful for the uniform injection of the transpiring water. This characteristic is also conducive to obtaining a more uniform water film protection.     

真空热处理炉布料矩阵优化仿真分析

为了获得更高的加热效率和更好的温度均匀性,采用有限元软件建立了真空热处理炉加热过程仿真模型,并耦合PID算法用于温度控制。通过与实测温度对比,验证了仿真模型的准确性。借助该模型,模拟研究了布料矩阵对两种典型形状零件在真空热处理炉内加热特性的影响。模拟装炉时基于零件几何形状特征,对圆棒形工件采用顺排、叉排和环形排列3种形式,对圆盘形工件采用横排式和竖排式。研究结果表明:尽管零件形状和数量相同,但是随着布料矩阵的变化,加热效率和温度均匀性都会改变。对于圆棒形工件,采用环形排列不仅可以提高内部工件的加热速率,而且相较于叉排式可以将最大温差减小36 ℃;对于圆盘形工件,由水平式改为竖直式布料可以将最大温差由248 ℃减小至171 ℃。     

Numerical study on premixed hydrogen/air combustion characteristics and heat transfer enhancement of micro-combustor embedded with pin fins

Aimed at improving the energy output performance of the Microthermal Photovoltaic (MTPV) system, it is necessary to optimize the structure of the micro combustor. In this paper, micro combustor with in-line pin fins arrays (MCIPF) and micro combustor with both end-line pin fins arrays (MCEPF) were presented to realize the efficient combustion and heat transfer enhancement, and the influence of inlet velocity, equivalent ratio, and materials on thermal performance was investigated. The results showed that pin fins embedding is beneficial to improving combustion, and the combustion efficiency of MCIPF and MCEPF reaches 98.5% and 98.7%, which is significantly higher than that of the conventional cylindrical combustor (MCC). However, with the increase of inlet velocity from 8 m/s to 14 m/s, MCIPF exhibits the highest external wall temperature with a range of (1302–1386 K), while MCEPF maintains the best temperature uniformity. As the inlet velocity increases to 10 m/s, the external wall temperature and temperature uniformity reach the optimum. Besides, under the conditions of different equivalence ratios, both external wall temperature and heat flux increases first and then decreases, meanwhile the temperature uniformity of MCEPF is significantly improved compared with that of MCIPF, they all exhibit the highest external wall temperature with an equivalence ratio of 1.1, and the thermal performance is greatly enhanced. By comparing the heat transfer performance of combustors with different materials based on MCEPF, it is interesting to find that the application of high thermal conductivity materials can not only increase the external wall temperature, but also improve the temperature uniformity. Therefore, materials with high thermal conductivity such as Aluminum, Red Copper and Silicon Carbide should be selected for application in micro combustors and their components. The current work provides a new design method for the enhanced heat transfer of the micro combustor.     

Mixing of low-dose cohesive drug and overcoming of pre-blending step using a new gentle-wing high-shear mixer granulator

The objective of this study was to examine the influence of drug amount and mixing time on the homogeneity and content uniformity of a low-dose drug formulation during the dry mixing step using a new gentle-wing high-shear mixer. Moreover, the study investigated the influence of drug incorporation mode on the content uniformity of tablets manufactured by different methods. Albuterol sulfate was selected as a model drug and was blended with the other excipients at two different levels, 1% w/w and 5% w/w at impeller speed of 300?rpm and chopper speed of 3000?rpm for 30?min. Utilizing a 1?ml unit side-sampling thief probe, triplicate samples were taken from nine different positions in the mixer bowl at selected time points. Two methods were used for manufacturing of tablets, direct compression and wet granulation. The produced tablets were sampled at the beginning, middle, and end of the compression cycle. An analysis of variance analysis indicated the significant effect (p?uniformity of the powder blend and the corresponding tablets. For 1% w/w and 5% w/w formulations, incorporation of the drug in the granulating fluid provided tablets with excellent content uniformity and very low relative standard deviation (～0.61%) during the whole tableting cycle compared to direct compression and granulation method with dry incorporation mode of the drug. Overall, gentle-wing mixer is a good candidate for mixing of low-dose cohesive drug and provides tablets with acceptable content uniformity with no need for pre-blending step.