Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia

Skeletal muscle is a highly adaptable organ, and its amount declines under catabolic conditions such as critical illness. Aging is accompanied by a gradual loss of muscle, especially when physical activity decreases. Intensive care unit-acquired weakness is a common and highly serious neuromuscular complication in critically ill patients. It is a consequence of critical illness and is characterized by a systemic inflammatory response, leading to metabolic stress, that causes the development of multiple organ dysfunction. Muscle dysfunction is an important component of this syndrome, and the degree of catabolism corresponds to the severity of the condition. The population of critically ill is aging; thus, we face another negative effect—sarcopenia—the age-related decline of skeletal muscle mass and function. Low-grade inflammation gradually accumulates over time, inhibits proteosynthesis, worsens anabolic resistance, and increases insulin resistance. The cumulative consequence is a gradual decline in muscle recovery and muscle mass. The clinical manifestation for both of the above conditions is skeletal muscle weakness, with macromolecular damage, and a common mechanism—mitochondrial dysfunction. In this review, we compare the molecular mechanisms underlying the two types of muscle atrophy, and address questions regarding possible shared molecular mechanisms, and whether critical illness accelerates the aging process.     

Platelet Derivatives and the Immunomodulation of Wound Healing

Besides their primary role in hemostasis, platelets contain a plethora of immunomodulatory molecules that profoundly affect the entire process of wound repair. Therefore, platelet derivatives, such as platelet-rich plasma or platelet lysate, have been widely employed with promising results in the treatment of chronic wounds. Platelet derivatives provide growth factors, cytokines, and chemokines targeting resident and immigrated cells belonging to the innate and adaptive immune system. The recruitment and activation of neutrophils and macrophages is critical for pathogen clearance in the early phase of wound repair. The inflammatory response begins with the release of cytokines, such as TGF-β, aimed at damping excessive inflammation and promoting the regenerative phase of wound healing. Dysregulation of the immune system during the wound healing process leads to persistent inflammation and delayed healing, which ultimately result in chronic wound. In this review, we summarize the role of the different immune cells involved in wound healing, particularly emphasizing the function of platelet and platelet derivatives in orchestrating the immunological response.     

基于图像识别的湿地外来入侵物种监测系统的设计与实现

针对外来物种入侵对湿地生态环境构成的严重危害和潜在威胁,开发了湿地外来入侵物种监测系统。本系统基于Linux操作系统,选用Eclipse开发软件、MySQL数据库和Openlayers地理信息系统,应用人工智能百度AI开发平台的图像识别接口服务,实现了外来入侵物种名录管理、物种识别、物种上报等功能。经过测试,本系统识别准确度较高,对终端性能要求较低,运行基本正常稳定,具有较强的移植性,适用于相关监测系统识别功能的二次开发,可以有效支持湿地外来入侵物种监测工作。     

火电厂用中水水质问题及改善措施的分析

针对火电厂用于循环冷却水和锅炉补给水的中水水质不稳定的问题,介绍通过改进污水处理阶段的工艺和深度处理必电厂初级阶段中水以提高中水水质的措施,对节能减排、保护环境吴有重要意义.     

零极点配置智能PID控制器在系统控制中的应用

为解决未知系统的PID控制问题,根据PID控制及零极点配置控制理论,详细讨论了零极点配置PID控制器、智能PID控制器的构成过程.该控制器结构简单,实用性强,控制器的阶数仅与被控系统的传递函数分子多项式阶数m有关,而与分母多项式阶数n无关,可以用低阶控制器控制高阶系统,通过大量的仿真试验研究,说明该智能控制器具有良好的自适应性和鲁棒性.     

动力调谐陀螺仪的瞬态动力学及误差分析

为了建立陀螺仪在过载—振动复合环境下的误差模型,应用有限元分析软件ANSYS,针对某型导弹使用的动力调谐陀螺仪的结构,建立基于具体参数的实体和有限元动力学模型,并开展了陀螺仪的瞬态动力学分析研究,由此计算由于陀螺转子和平衡环的质心偏移造成的陀螺仪漂移误差,得到在过载—振动复合环境下陀螺仪漂移角速度与在过载、振动单一环境下漂移角速度之间的关系。     

一种新型的简易测温系统电路

介绍一种新型的简易测温系统电路。测温系统采用一种新的电流／脉宽转换电路,与常用的测温系统比较,具有测量范围广、精度高、构成简单、成本低廉等优点。     

矿山电机控制系统原理

矿山风机中使用的交流电机驱动,其消耗与浪费非常严重。针对DTC和VC控制系统的现状及实用化技术提出了一些看法。     

基于日志副本的Raft共识算法优化

在基于三副本策略的分布式存储系统中, 当存储节点上的硬盘出现故障时, 常见的处理方式是等待系统预设的时间. 如果该故障硬盘超时未恢复, 才开始恢复故障硬盘上的副本. 这种处理方式存在的问题是, 当三副本组中存在故障副本时, 如果该副本组再有一个副本所在的硬盘发生故障, 将导致系统无法继续提供服务, 且不能自动恢复. 本文提出一种基于日志副本的改进的Raft共识算法, 即LR-Raft (log replica based Raft), 日志副本没有完整状态机, 可以快速加入集群, 并参与投票与共识, 提升了存在故障硬盘时系统的可用性; 可以解决短时间内三副本中两个副本故障导致集群不可用和丢失数据的问题. 实验结果表明, 在副本组中引入日志副本后, 与原Raft相比, LR-Raft在不同的工作负载下读写时延均明显降低, 吞吐量显著提升.     

计算机检修管理系统中Gateway的设计与性能测试

针对电厂状态检修的实际需求,采用国产的三维力控软件平台与PI数据库和Oracle数据库相结合,完成了石嘴山电厂状态检修系统计算机检修管理系统(CMMS)的详细设计。其中,状态检修系统需要的绝大部分实时数据都取自厂级监控信息系统(SIS)的PI实时数据库,因此,PI数据库和力控实时数据库之间的接口Gateway的性能将直接决定整个状态检修系统的性能。采用VC/C 、PI数据库的API和力控平台的ActiveX控件,开发了PI和力控系统间的Gateway,并对Gateway的结构进行了优化。通过对软件平台中Gateway的极限测试表明,该软件平台能满足状态检修系统性能指标的要求。