153Sm,113,117Snm烷基膦酸配合物的表观脂水分配系数及与BSA的结合率

测定了NTMP(次氮三亚甲基膦酸),HEDTMP(N-(羟乙基)乙二胺基三亚甲基膦酸),DCTMP(1,2-环己二胺四亚甲基膦酸),EDTMP(乙基二胺基四亚甲基膦酸),DTPMP(二乙基三胺基五亚甲基膦酸)的^153Sm配合物以及HEDTMP,EDTMP,DTPMP的^113,117Sn^m配合物在正辛醇-水中的表观脂水分配系数和在0．5％牛血清白蛋白(BSA)水溶液中与BSA的结合率。结果表明,这些配合物在正辛醇一水中的相对表观脂水分配系数和在BSA水溶液中与BSA的相对结合率呈线性正相关。两者之间的线性关系为这类配合物脂水分配系数的预测提供了一种新方法,同时也表明,在金属配合物与BSA的结合过程中,疏水作用力起着重要作用。     

Preparation and properties of 117m Sn(IV)-TTHMP in in-vitro and in small animals

In this work,TTHMP was synthesized and labelled with 117m Sn.The preparation conditions,stability and lipophilicity of 117m Sn(IV)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was studied.It was found that the quantity of TTHMP and pH value of the prepararion solution had vital effects on the labeling yield of 117m Sn(IV)-TTHMP.It was also found that 117m Sn(IV)-TTHMP was hydrophilic and stable at room temperature and 37℃ in open air 117m Sn(IV)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals.This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.     

Fabrication and Characteristics of Poly(benzimidazole/fluoro/ether/siloxane/amide)/Sulfonated Polystyrene/Silica Nanoparticle-Based Proton Exchange Membranes Doped With Phosphoric Acid

Novel poly(benzimidazole/fluoro/ether/siloxane/amide) (PBFESA) was developed for the formation of hybrid proton exchange membrane. Afterward, phosphoric acid doped PBFESA/PS-S/SiNPs was prepared with PBFESA, sulfonated polystyrene (PS-S), and 0.1–2 wt% silica nanoparticles (SiNPs). Tensile strength of acid doped PBFESA/PS-S/SiNPs nanocomposites increased from 63.9 to 68.1 MPa with increasing SiNPs loading. They had higher ion exchange capacity (IEC) of 2.3–3.3 mmol/g and proton conductivity of 1.9–2.7 S/cm at 80°C (higher than perfluorinated Nafion 117 membrane 1.1 × 10^?1 S/cm). A H₂/O₂ fuel cell using PBFESA/PS-S/SiNPs 2 (IEC 3.3 mmol/g) showed better performance than Nafion 117 at 40°C (30% RH).     

不同腐蚀试验的电化学阻抗谱评价

采用电化学阻抗谱分析了环氧涂层的介质浸泡、ASTM-B117盐雾试验、PROHESION循环试验的性能变化。实验结果表明:介质浸泡更侧重考察涂层的屏蔽作用,对环氧-聚酰胺体系酸性电解质更容易导致涂层失效;而盐雾试验更容易导致涂层吸收水分,干湿交替增加了有机涂层吸水能力;划痕试验表明样板在ASTM-B117和PRO-HESION遵循不同的腐蚀机理。     

Preparation and properties of ~(117m)Sn(Ⅳ)-TTHMP in in-vitro and in small animals

In this work,TTHMP was synthesized and labelled with ~(117m)Sn.The preparation conditions,stability and lipophilicity of ~(117m)Sn(Ⅳ)-TTHMP were investigated.Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the preparation solution had vital effects on the labeling yield of ~(117m)Sn(Ⅳ)-TTHMP.It was also found that ~(117)Sn(Ⅳ)-TTHMP was hydrophilic and stable at room tempera- ture and 37℃in open air.~(117m)Sn(Ⅳ)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals.This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.     

Novel sulfonated poly(oxybenzimidazole) membranes bearing sulfo-napthalimide pendant groups with improved proton conductivity and fuel cell performance

The goal of the present work is to introduce a new aromatic bulky six-membered sulfo-napthalimide pendant groups, specifically 2-(2,5-dicarb-oxyphenyl-1,3-dioxo- 2,3-didihydro-1Hbenzo[de]isoquinoline-6-sulfonate (PDDDBIS), into the poly(oxybenzimidazole) (POBI) main chain. As no sulfo-napthalimide-bearing POBI has been reported yet, this could be a potential strategy to improve the solubility, processability, and proton conductivity of sulfonated POBIs in addition to boosting fuel cell performance. Out of six membranes synthesized, one sulfonated POBI membrane with pendant PDDDBIS groups (SPOBI-100) exhibited a fairly high proton conductivity of 0.172 S/cm, which is higher than Nafion-117 (0.161 S/cm) at 90 °C. Notably, an H₂/O₂ PEM fuel cell fabricated with the SPOBI-100 membrane displayed good performance with the maximum peak power density of 547 mW/cm² and output current density of 1259 mA/cm² in 0.99 V at 90 °C with100% RH, which is higher than the Nafion 117 power density (519 mW/cm²) and current density (1215 mA/cm²) under the same testing conditions.     

反应条件对乙酸仲丁酯合成的影响

采用KC 117型阳离子酸性树脂催化剂,在200 m L固定床反应器上,以乙酸和炼厂碳四(C4)为原料合成乙酸仲丁酯(Sec-BA),考察了反应温度、原料质量空速和酸烯摩尔比对丁烯转化率和Sec-BA选择性的影响。结果表明,在反应温度为60℃,进料质量空速为2.5 h-1,酸烯摩尔比为2.5,反应压力为0.80 MPa的最佳工艺条件下,丁烯转化率大于87%,Sec-BA选择性大于96.5%,产品收率大于83.9%。     

Zul?ssigkeit des Rechtswegs für Ansprüche aus wasserrechtlicher Vereinbarung

Für Ansprüche aus einer durch Bescheid der Wasserrechtsbeh?rde beurkundeten freiwilligen privatrechtlichen Vereinbarung über ein Wasserbezugs- und -leitungsrecht aus einer privaten Quelle gegen Arbeits- und Kostenbeteiligung, sind die Gerichte zust?ndig. ?ffentlich rechtlicher Natur ist der Anspruch nur dann, wenn der Wasserbezug auch von der Beh?rde zwangsweise einger?umt h?tte werden k?nnen oder als kraft Gesetzes einger?umt gelten k?nnte.     

胃肠道间质瘤的光镜、电镜及免疫组化研究

目的：进一步探讨胃肠道间质瘤（GISTs）的组织起源及病理诊断问题。方法：18例手术切除标本常规石蜡切片、电镜制片及免疫组化EnVision法标记，光镜及电镜观察。结果：本组18例光镜下组织学形态均表现为梭形细胞。电镜观察：无明显平滑肌及神经分化者14例，伴有平滑肌分化的3例，伴有神经分化的1例。免疫组化染色：18／18例CD117阳性和15／18例CD34阳性，SMA同时阳性者1例，S－100同时少量阳性者2例，Desmin和NSE均为阴性。18例GISTs被诊断和恶性13例，良性5例。结论：GISTs是一类具有特征性的独立的肿瘤，CD117是GISTs较具特异性的标记物。目前GISTs的良恶性诊断仍需通过包括光镜、电镜观察在内的多种综合指数判断并结合临床随访。     

Adsorption of ^117mSn（IV）—EDTMP on hydroxyapatite and collagen

Some organic phosphines labeled with ^117mSn(IV) have been proved promising for imaging and pain palliation of bone tumor.In this paper,a preliminary investigation on the adsorption characteristics of EDTMP(ethelenediaminetetramethylene phosphoric acid)labeled with ^117Sn(IV) on HA( hydroxyapatitie)and collagen,and an investigation on the adsorption mechanism of ^117mSn(IV)-EDTMP on HA was presented.