关于燃气轮机清吹阀故障处理与分析

结合发生的燃料模块PM4清吹阀出现严重内漏,导致机组无法正常启动和如何排除故障的实例,来说明清吹阀在系统中的重要性。     

Epileptic Mechanisms Shared by Alzheimer’s Disease: Viewed via the Unique Lens of Genetic Epilepsy

Our recent work on genetic epilepsy (GE) has identified common mechanisms between GE and neurodegenerative diseases including Alzheimer’s disease (AD). Although both disorders are seemingly unrelated and occur at opposite ends of the age spectrum, it is likely there are shared mechanisms and studies on GE could provide unique insights into AD pathogenesis. Neurodegenerative diseases are typically late-onset disorders, but the underlying pathology may have already occurred long before the clinical symptoms emerge. Pathophysiology in the early phase of these diseases is understudied but critical for developing mechanism-based treatment. In AD, increased seizure susceptibility and silent epileptiform activity due to disrupted excitatory/inhibitory (E/I) balance has been identified much earlier than cognition deficit. Increased epileptiform activity is likely a main pathology in the early phase that directly contributes to impaired cognition. It is an enormous challenge to model the early phase of pathology with conventional AD mouse models due to the chronic disease course, let alone the complex interplay between subclinical nonconvulsive epileptiform activity, AD pathology, and cognition deficit. We have extensively studied GE, especially with gene mutations that affect the GABA pathway such as mutations in GABA_A receptors and GABA transporter 1. We believe that some mouse models developed for studying GE and insights gained from GE could provide unique opportunity to understand AD. These include the pathology in early phase of AD, endoplasmic reticulum (ER) stress, and E/I imbalance as well as the contribution to cognitive deficit. In this review, we will focus on the overlapping mechanisms between GE and AD, the insights from mutations affecting GABA_A receptors, and GABA transporter 1. We will detail mechanisms of E/I imbalance and the toxic epileptiform generation in AD, and the complex interplay between ER stress, impaired membrane protein trafficking, and synaptic physiology in both GE and AD.     

基于GE PA的卷烟厂制丝线MES的设计

分析了卷烟厂制造执行系统的特点以及发展现状。以PA平台为基础,设计了一套卷烟厂制丝线的制造执行系统,主要由系统管理、生产建模、生产管理、质量管理、设备管理、人员管理等模块组成。该系统的开发大大提高了卷烟厂制丝车间的生产管理水平。     

为谁而战——论新历史小说的战争观念

以《大年》和《回廊之椅》为代表,分析了新历史小说中体现出来的男女作家在战争观念上的差异,指出了男性作家“为美女海伦而战”的传统战争观念与女性作家战争观念的不同,进而探讨了当前存在的性别差异和有待深化的性别平等现状。     

洞库门一维温度模型的建立和解法

为了分析洞库门表观温度及其影响因素,建立了洞库门的一维温度模型,详细讨论了模型的初始和边界条件.通过虚拟网格点法处理边界条件,得出了差分方程GE格式的完整形式.最后,实例表明了模型的合理性.     

应用于100GE高速变速箱设计方法及时序分析

该文介绍了 4 种变速箱设计方法，并对它们进行时序分析。通过对比单元数量(面积)、功耗、速度及稳定性，选择了一种基于轮循存储方式的变速箱应用到 100GE 物理编码子层电路中。该变速箱可以在一段时间范围内开始输出，克服了输入输出时钟相位差的影响，提高了电路的速度和稳定性。经过结构优化及流水线结构设计，该变速箱的时钟速度超过 700 MHz。另外，采用 0.18 μm互补金属氧化物半导体工艺对物理编码子层电路进行流片，测试结果表明该电路能够以 100 Gb/s 速率稳定工作，进一步证明了变速箱设计的正确性。