夯扩桩桩头质量的控制

通过工程实例分析了影响夯扩桩桩头质量的因素,提出了控制夯扩桩桩头质量的措施,以进一步提高夯扩桩的质量.     

Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry for Quantification of Glycyrrhetic Acid in Human Plasma

A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) for the determination of glycyrrhetic acid in human plasma with ginsenoside Rh2 as internal standard was developed and validated. The plasma samples were prepared via liquid-liquid extraction with ethyl acetate. Chromatographic separation was accomplished on a Venusil MP-C18(50 mm×2.1 mm, 5μm i.d.) column at 25℃. The mobile phase consisted of acetonitrile/5 mmol·L-1 ammonium acetate(10:90, volume ratio) at a flow rate of 0.4 mL/min. Negative electrospray ionization was utilized as the ionization source. Glycyrrhetic acid and internal standard were determined via the mutiple reaction monitoring of precursor→production ion transitions at m/z 469→425, 409 and m/z 621→161,respectively. Each sample was chromatographed within 2.5 min. The lower limit of uantification was 0.50 ng/mL for 200 μL of plasma sample and the linear range was from 0.50 ng/mL to 800 ng/mL. The intra-and inter-day precisions were less than 8.76% in terms of relative standard deviation(RSD), and the accuracy was within a range of -3.25%-1.32% in terms of relative error(RE). The method was successfully applied to the pharmacokinetic studies of glycyrrhetic acid in healthy male Chinese volunteers after a single oral administration of 75 mg of glycyrrhizin.     

基于函数插值的柯氏质量流量计信号处理方法

对基于离散傅里叶变换(DFT)信号处理方式的柯氏质量流量计来说,影响其精度的关键问题是如何实现信号的整周期采样。提出了一种全新的方法,用采样率固定不变的采样数据,通过软件实时地确定信号的频率并且实现信号整周期重新采样。实验结果表明该方法在求取相位差时具有极高的精度。     

The improved neutral network and its application for valuing rock mass mechanical parameter

The artificial neutral network（ANN） has the ability that self-study and self-remember, its 3 layers BP network has been applied extensively, but sometimes because of serious multi-correlation between the variables, and a few observations while many variables, there usually will result into paralyzing in study, and the neutral network further development is restricted in the system to some extent. The partial least square regression（PLS） has its advantage of building the calculation model between the variables with strong multi-correlation, especially much effective on a few data and many variables. So a new and effective method-improved neutral network has been introduced-the neutral network based on the PLS. The results of example show the improved method has a few calculations and high accuracy, and provide a new way for valuing the rock mass mechanical parameters.     

深部开采岩体变形分析的双曲函数法

在软岩地层深部厚矿体开采条件下,给出了用于预测分析地下开采岩体移动变形的双曲正切函数模型,采用该模型对国内某地下矿山深部开采岩体移动变形进行了具体的计算分析,并与概率积分法理论分析结果和实测数据进行了对比,结果令人满意.分析结果表明,本文所提出的理论方法适用于预测分析深部矿体开采引起的岩体移动变形问题.     

Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified using double solvents in the extraction of analytes. With the modified method, some of the previously undetectable metabolites were recovered and subtle differences in the metabolic changes upon exposure to a single dose of VPA between males and female rats were identified. In male rats, changes in 2-hydroxybutyric acid, pipecolic acid, tetratriacontane and stearic acid were found between the control and treatment groups at various time points from 2.5 h up to 24 h. In contrast, such differences were not observed in female rats, which could be caused by the vast inter-individual variations in metabolite levels within the female group. Based on the measured DBS drug concentrations, clearance and apparent volume of distribution of VPA were estimated and the values were found to be comparable to those estimated previously from full blood drug concentrations. The current study indicated that DBS is a powerful tool to monitor drug levels and metabolic changes in response to drug treatment.     

高压开关运动系统等效质量的计算

提出用“基本形块”分割法来计算形状复杂构件的转动惯量,这种方法易于写出通用算式,并便于用作图法简化计算.在速度比方面,介绍了作图解法和适于计算机使用的算式.     

斜坡非饱和带低渗透岩石中水气分子的扩散机理

根据分子运动论,对水气分子在低渗透岩石中的扩散模式进行研究,得出水气分子中的主要气体H2O、CO2以及O2在新鲜二长岩和玄武岩中的扩散为过渡型扩散.通过计算得到三者的有效扩散系数.以微砂质细粒长石石英砂岩为研究对象,在电子显微镜下获得砂岩的铸体薄片图像,并对其进行处理,建立砂岩的二维孔隙扩散模型,模拟岩石风化过程中水气分子在砂岩孔隙内的扩散过程,得到砂岩模型内部的速度分布图、压力分布图和雷诺数图.结果表明,天然状态下,水气分子的流动主要出现在胶结物受腐蚀的风化区域.胶结物溶蚀产生的贯通孔隙是水气分子的主要扩散通道和贮存场所.水气分子在砂岩内部孔隙中的流动符合流体流动的基本规律,雷诺数的量级为10-3,流动状态为层流.同时对风化岩石的剖面进行分带,分析了水气分子扩散对岩石风化产生的影响.     

Influence of the additives argon, O2, C4F8, H2, N2 and CO on plasma conditions and process results during the etch of SiCOH in CF4 plasma

Reactive ion etch processes for modern interlevel dielectrics become more and more complex, especially for further scaling of interconnect dimensions. The materials will be damaged within such processes with the result of an increase in their dielectric constants. The capability of selected additives to minimize the low-k sidewall damage during reactive ion etching (RIE) of SiCOH materials in fluorocarbon plasmas was shown in different works in the past. Most of the investigated additive gases alter the fluorine to carbon ratio as well as the dissociation of the parent gas inside the etch plasma. The result is a changed etch rate, a modified polymerization behavior and other characteristics of the process induced SiCOH damage. Heavy inert ions like argon will be accelerated to the sample surface in the cathode dark space and enhance therewith the sputter yield on the SiCOH network [1]. In this paper the additives Ar, O₂, C₄F₈, H₂, N₂ and CO were added to a conventional CF₄ etch plasma. We try to provoke different changes in the plasma conditions and therewith in the process results. Contact angle measurements, spectroscopic ellipsometry, Hg-probe analysis, FTIR measurements and SEM cross-sections were used to overview the additive induced modifications. To understand the influences of the additives gases more exactly, changes in the physical and chemical plasma behavior must be analyzed. Therefore quadrupole mass spectrometry (QMS) and quantum cascade laser absorption spectroscopy (QCLAS) were used.     

Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2

Lysyl oxidase-like 2 (LOXL2) catalyzes the oxidative deamination of peptidyl lysines and hydroxylysines to promote extracellular matrix remodeling. Aberrant activity of LOXL2 has been associated with organ fibrosis and tumor metastasis. The lysine tyrosylquinone (LTQ) cofactor is derived from Lys653 and Tyr689 in the amine oxidase domain via post-translational modification. Based on the similarity in hydrodynamic radius and radius of gyration, we recently proposed that the overall structures of the mature LOXL2 (containing LTQ) and the precursor LOXL2 (no LTQ) are very similar. In this study, we conducted a mass spectrometry-based disulfide mapping analysis of recombinant LOXL2 in three forms: a full-length LOXL2 (fl-LOXL2) containing a nearly stoichiometric amount of LTQ, Δ1-2SRCR-LOXL2 (SRCR1 and SRCR2 are truncated) in the precursor form, and Δ1-3SRCR-LOXL2 (SRCR1, SRCR2, SRCR3 are truncated) in a mixture of the precursor and the mature forms. We detected a set of five disulfide bonds that is conserved in both the precursor and the mature recombinant LOXL2s. In addition, we detected a set of four alternative disulfide bonds in low abundance that is not associated with the mature LOXL2. These results suggest that the major set of five disulfide bonds is retained post-LTQ formation.