A cluster-DEE-based strategy to empower protein design

The Medical and Pharmaceutical industries have shown high interest in the precise engineering of protein hormones and enzymes that perform existing functions under a wide range of conditions. Proteins are responsible for the execution of different functions in the cell: catalysis in chemical reactions, transport and storage, regulation and recognition control. Computational Protein Design (CPD) investigates the relationship between 3-D structures of proteins and amino acid sequences and looks for all sequences that will fold into such 3-D structure. Many computational methods and algorithms have been proposed over the last years, but the problem still remains a challenge for Mathematicians, Computer Scientists, Bioinformaticians and Structural Biologists. In this article we present a new method for the protein design problem. Clustering techniques and a Dead-End-Elimination algorithm are combined with a SAT problem representation of the CPD problem in order to design the amino acid sequences. The obtained results illustrate the accuracy of the proposed method, suggesting that integrated Artificial Intelligence techniques are useful tools to solve such an intricate problem.     

浅析企业员工培训存在的问题和对策

文中主要关注了企业员工培训工作从思考到行动上存在着一定的问题,并对其成因做出了较为深入的分析,为加深理解企业员工培训内涵。坚持以人为本的理念,坚持建立科学有效的激励体系角度。提出了一些切实可行的具体对策。     

弹道方程边值问题中的直射弹道公式

本文探求了属于微分方程边值问题的直射弹道公式,以形简、意明、精确度高、研究方法的多样性和事物规律的不同表现形式为特征。在直射弹道的定义和数学描述之后,先从它的微分方程出发推导出了公式;再从方程的数字解出发探寻并确立了其规律性。     

基于Tikhonov正则化的WSN多边定位算法研究

节点定位是无线传感器网络实现监测和跟踪的一个重要前提.针对多边定位中的不适定问题.提出了一种基于Tikhonov正则化方法的定位算法,研究了定位模型的建立、正则化参数的选取方法以及最优定位参考点数的选取等问题.实验结果表明本算法与典型的极大似然估计法相比,较大幅度地提高了定位精度,当a值选取600,采用5个参考节点时,定位精度可达到1米.     

煤矿竖井井筒装备制定施工方案须注意的问题

通过对煤矿竖井井简装备安装的简要分析,根据井简装备安装工程的特殊性,提出了井筒装备安装工程制定、论证施工方案过程中应注意的问题,对类似井简装备的大型工程施工具有指导意义。     

基于量子布谷鸟搜索的认知无线网络频谱分配

为了有效解决认知无线网络频谱分配的离散优化问题,将量子计算引入布谷鸟搜索算法,提出了一种新的组合优化算法——量子布谷鸟搜索算法。该算法使用量子鸟窝表征问题的多维解,通过Lévy flights随机游动方式和量子突变策略快速搜索到全局最优位置。通过使用基准函数验证了算法的高效性,并提出了一种基于量子布谷鸟搜索的认知无线网络频谱分配方法。然后与经典频谱分配算法在不同的网络效益函数下进行仿真性能比较。结果表明,所提出的频谱分配方法能够较快找到全局最优解,并且在不同网络效益函数下均优于已有的经典频谱分配算法。     

Switching on Fluorescent Emission by Molecular Recognition and Aggregation Dissociation

A generic and effective approach to “switch on” and enhance the two‐photon fluorescence (TPF) emission of quenched TPF molecules, i.e., fluorene derivatives, is reported in terms of molecular recognition with a decoupling medium. Such a medium, in this case Bombyx mori silk, can recognize TPF molecules and inhibit the aggregation of the TPF molecules. The designed TPF molecules are 2,7‐bis[2‐(4‐nitrophenyl)ethenyl]‐9,9‐dibutylfluorene ( 4NF ) and 2,7‐bis[2‐(4‐nitrophenyl)ethenyl]‐9,9‐dioctylfluorene ( 8NF ), which exhibit suppressed TPF emission owing to molecular‐stacking‐led aggregation in the solid form. Due to the specific recognition between –NO₂ in the quenched fluorescent molecules and –NH groups in silk fibroin molecules, the aggregated molecules of 4NF / 8NF molecules are decoupled. This decoupling gives rise to a significant increase in TPF quantum yields. The mechanism is further confirmed by replacing the terminal group –NO₂ in 8NF with –CH₃ (in 2,7‐bis[2‐(4‐methylphenyl)ethenyl]‐9,9‐dioctylfluorene; 8MF ) to eliminate the possibility of molecular recognition. As predicted, in the case of 8MF the switching‐on effect is eliminated. Completely new TPF silk fibers can additionally be applied in real‐time 3D high‐resolution TPF scaffold bioimaging.     

不是问题的问题

概述了我国PCB工业是在资本主义社会包围下发展起来的,资本主义社会发生经济危机带来的问题。我们要看到经济危机过后的新的产品和市场的平台。     

Ku波段螺旋波纹波导回旋行波管色散特性研究

为抑制回旋行波管的自激振荡和增加回旋行波管带宽,俄罗斯G.Denisov等人提出一种新型回旋行波管结构——螺旋波纹波导回旋行波管。通过螺旋波纹波导的特殊结构使通过波导的两种模式发生耦合,耦合出一种新的工作模式,从而改变色散特性,达到抑制自激振荡和增加带宽的目的。通过螺旋波纹波导的色散方程,分析其色散曲线,从而分析螺旋波纹波导作为回旋行波管高频系统的优势。     

一种适用于概率LDPC译码器的双路更新边缘存储器

针对采用传统边缘存储器结构的概率低密度奇偶校验(Low Density Parity Check,LDPC)译码器中仍存在锁存问题的现象,借鉴全并行Turbo译码器中的多路更新策略,提出了一种增强的变量节点和校验节点双路更新边缘存储器结构。利用双路更新结构引入的增强随机选择特性,可以显著降低概率迭代译码过程中的锁存现象。仿真分析表明,相比于单路更新结构,采用双路更新边缘存储器结构的概率LDPC译码器能够在误比特率接近10-4量级处获得0.4 dB左右的译码性能增益,同时也能够显著降低迭代译码周期数量,提升译码速率。