The Bivariate Transmuted Family of Distributions: Theory and Applications

The bivariate distributions are useful in simultaneous modeling of two random variables. These distributions provide a way to model models. The bivariate families of distributions are not much widely explored and in this article a new family of bivariate distributions is proposed. The new family will extend the univariate transmuted family of distributions and will be helpful in modeling complex joint phenomenon. Statistical properties of the new family of distributions are explored which include marginal and conditional distributions, conditional moments, product and ratio moments, bivariate reliability and bivariate hazard rate functions. The maximum likelihood estimation (MLE) for parameters of the family is also carried out. The proposed bivariate family of distributions is studied for the Weibull baseline distributions giving rise to bivariate transmuted Weibull (BTW) distribution. The new bivariate transmuted Weibull distribution is explored in detail. Statistical properties of the new BTW distribution are studied which include the marginal and conditional distributions, product, ratio and conditional momenst. The hazard rate function of the BTW distribution is obtained. Parameter estimation of the BTW distribution is also done. Finally, real data application of the BTW distribution is given. It is observed that the proposed BTW distribution is a suitable fit for the data used.     

X80管线钢焊接热影响区的韧性分析

X80管线钢在焊接过程中,热影响区由于受到焊接过程热的作用,其组织和性能会发生较大的变化.韧性是天然气长输管线的重要性能,采用热模拟技术、现代工程测试手段和显微分析方法,分析了不同热输入参数下X80管线钢焊接热影响区粗晶区(CGHAZ)韧性(夏比冲击功和CTOD)的差异及其原因.在一定范围内,较高焊接热输入下CGHAZ的韧性比较低热输入下CGHAZ的韧性明显高,超过一定范围,随着热输入的增加韧性激剧下降.造成不同热输入下韧性差异的根本原因是由CGHAZ显微组织的差异引起的.较低的热输入下CGHAZ中产生了一定量的低碳马氏体,从而导致韧性较差.     

Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5′ Terminal Regions

Flavivirus genus includes many deadly viruses such as the Japanese encephalitis virus (JEV) and Zika virus (ZIKV). The 5′ terminal regions (TR) of flaviviruses interact with human proteins and such interactions are critical for viral replication. One of the human proteins identified to interact with the 5′ TR of JEV is the DEAD-box helicase, DDX3X. In this study, we in vitro transcribed the 5′ TR of JEV and demonstrated its direct interaction with recombinant DDX3X (K_d of 1.66 ± 0.21 µM) using microscale thermophoresis (MST). Due to the proposed structural similarities of 5′ and 3′ TRs of flaviviruses, we investigated if the ZIKV 5′ TR could also interact with human DDX3X. Our MST studies suggested that DDX3X recognizes ZIKV 5′ TR with a K_d of 7.05 ± 0.75 µM. Next, we performed helicase assays that suggested that the binding of DDX3X leads to the unwinding of JEV and ZIKV 5′ TRs. Overall, our data indicate, for the first time, that DDX3X can directly bind and unwind in vitro transcribed flaviviral TRs. In summary, our work indicates that DDX3X could be further explored as a therapeutic target to inhibit Flaviviral replication     

基于Web services的WebGISVisA体系结构研究与实现*

针对目前网络地理信息系统体系结构难以实现Internet环境下的异构空间信息的互操作问题,深入分析其主要原因,在对现有网络地理信息系统的三层体系结构进行深入分析的基础上,提出一种基于Web services的网络地理信息系统体系结构(Web-based geographical information services visualization architecture,WebGISVisA).WebGISVisA体系结构通过Web services对各个地理信息系统组件进行包装,实现各个组件的跨平台操作,从技术上使得客户端和服务端达到了负载平衡,完成了WebGIS三维的虚拟现实,实现了在Internet下空间数据互操作和跨平台的功能,最大限度地达到数据共享.     

Mn-Nb-Mo系X70级管线钢奥氏体再结晶规律的研究

研究了Mn-Nb-Mo系XT0级管线钢的再结晶规律，分析了变形温度、变形量等工艺参数对变形奥氏体再结晶百分数的影响，为现场控轧工艺的制定提供了理论依据。     

Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7

Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular components, we and explored the anti-thrombogenic efficacy of blockade of the P2X purinoceptor 7 (P2X7). A confocal blood flow videomicroscopy system was performed on cryosections of internal mammary artery (IMA) or carotid plaque (CPL) determining/localizing platelets and fibrin. Blood from healthy donors elicited thrombi over arterial layers. Confocal microscopy associated thrombus with tissue presence of collagen type I, laminin, fibrin(ogen) and tissue factor (TF). The addition of antibodies blocking TF (aTF) or factor XI (aFXI) to blood significantly reduced fibrin deposition, variable platelet aggregation and aTF + aFXI almost abolished thrombus formation, showing synergy between coagulation pathways. A scarce effect of aTF over sub-endothelial regions, more abundant in tissue TF and bundles of laminin and collagen type I than deep intima, may suggest tissue thrombogenicity as molecular structure-related. Consistently with TF-related vascular function and expression of P2X7, the sections from CPL but not IMA tissue cultures pre-treated with the P2X7 antagonist A740003 demonstrated poor thrombogenesis in flow experiments. These data hint to local targeting studies on P2X7 modulation for atherothrombosis prevention/therapy.     

Synthesis and characterization of poly acrylic acid/graphite oxide nanocomposite

1　INTRODUCTIONOrganic intercalatedlayeredsolidshavebeenstudiedbyscientistsindifferentfieldsformanyyearsbecauseoftheirnew physicalandchemicalpropertiessuchaselectricalproperties[1] ,mechanicalproper ties ,thermalbehavior[2 ] ,surfaceandinterfacialproperties[3] .Graphiteoxide (GO)hasbeenstudiedformany years ,itsstructuralmodel[4 6 ] ,formationprocessandkinetics[7,8] havebeenstudiedindetail.IthasbeenreportedthatGOpossessesC OHande poxidefunctionalgroups[9] whichmakegraphiteox ideeasilyabs…     

X80管线钢埋弧焊匹配焊丝试验

通过分析高强度低合金钢焊缝熔敷金属常见显微组织对其力学性能的影响,确定X80管线钢用埋弧焊丝熔敷金属组织应以大量针状铁素体(AF)和少量粒状贝氏体(GB)的复合组织.从相变动力学原理出发,结合针状铁素体(AF)非自发形核机制和微合金组织韧化理论,选择Mn-Ni-Mo-Ti-B合金系进行X80管线钢匹配焊丝的试制.结果表明,合理选择和控制合金元素,可以获得理想的焊缝熔敷金属组织和强韧性以及低温韧性要求,试制的1号焊丝能够满足X80管线钢的使用要求.     

土壤中侵蚀性离子对X70钢的侵蚀作用研究

采用极化曲线并结合E-pH图分析，研究了土壤中主要侵蚀性离子CO2-3、HCO-3、SO2-4、Cl-对管线钢X70钢的侵蚀作用。结果表明：在酸性介质中，SO2-4、Cl-2种离子对X70钢的侵蚀能力无明显差别；X70钢在含有SO2-4、Cl-离子的介质中发生活性溶解，由于含有多种钝性元素以及材料的组织结构较均匀，X70钢在此介质中的耐蚀性优于A3钢。但在含有CO2-3、HCO-3的碱性体系中，X70钢的耐蚀性随pH值变化。在含有HCO-3的弱碱体系（pH=8）中，X70钢具有一定的钝化能力，但A3钢的耐蚀性优于X70钢，在含有CO2-3的中等碱体系（pH=10）中，X70钢的耐蚀性优于A3钢，在含有CO2-3的强碱体系中,A3钢的耐蚀性优于X70钢。 