一种有效的增益误差校准方法

本文针对增益误差对空间谱估计性能的影响，提出了一种基于算术平均值的平滑校准方法，并将它与其它核准方法进行了比较，理论分析和实验仿真均表明了本文提出的方法具有更好的稳健性能和校准效果。     

基于FPGA的QPSK信号解调技术研究

介绍了一种用数字锁相环对QPSK信号解调的方法,并将该算法在FPGA硬件中实现,给出了硬件实现FPGA的解调效果及解调的性能指标。通过解调算法和原理上的分析对QPSK信号解调全过程进行了详细说明。     

非间断软件回归测试模型研究

软件测试是开发过程的重要环节。回归错误在开发过程中严重影响着开发的效率,其隐匿特性也使得测试比较困难。因此,本文提出一种非间断测试的模型,用于加强对回归错误的管理,节约不必要的无谓工作时间,提高软件开发的效率。这种模型对用户开发行为进行模拟和推测,在经过大量的数据训练后,寻找测试行为、错误发生等开发动作的捕获点,从而找到最佳的测试策略。在不影响开发人员工作的前提下,可对当前最新的代码进行测试,最大程度上避免回归错误长期隐藏在前期代码中,保持整个开发过程的稳步前进。     

煤矿工业建筑设计

煤矿工业建筑的设计要满足工艺流程的要求和结构体系本身规范的要求,还要体现人性化设计理念。本文通过对准备车间一个单体建筑的设计过程的总结,呼吁整个行业能重视人性化设计理念。     

成品啤酒的自动统计报表管理

主要介绍了啤酒厂生产与销售中的各种自动统计报表,并简要说明了系统组成、关键编程及工作原理.     

Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis

The extracellular matrix (ECM) is an important regulator of excitability and synaptic plasticity, especially in its highly condensed form, the perineuronal nets (PNN). In patients with drug-resistant mesial temporal lobe epilepsy (MTLE), hippocampal sclerosis type 1 (HS1) is the most common histopathological finding. This study aimed to evaluate the ECM profile of HS1 in surgically treated drug-resistant patients with MTLE in correlation to clinical findings. Hippocampal sections were immunohistochemically stained for aggrecan, neurocan, versican, chondroitin-sulfate (CS56), fibronectin, Wisteria floribunda agglutinin (WFA), a nuclear neuronal marker (NeuN), parvalbumin (PV), and glial-fibrillary-acidic-protein (GFAP). In HS1, besides the reduced number of neurons and astrogliosis, we found a significantly changed expression pattern of versican, neurocan, aggrecan, WFA-specific glycosylation, and a reduced number of PNNs. Patients with a lower number of epileptic episodes had a less intense diffuse WFA staining in Cornu Ammonis (CA) fields. Our findings suggest that PNN reduction, changed ECM protein, and glycosylation expression pattern in HS1 might be involved in the pathogenesis and persistence of drug-resistant MTLE by contributing to the increase of CA pyramidal neurons’ excitability. This research corroborates the validity of ECM molecules and their modulators as a potential target for the development of new therapeutic approaches to drug-resistant epilepsy.     

Novel Systemic Treatment Modalities Including Immunotherapy and Molecular Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in the oral cavity and larynx are usually associated with tobacco and/or alcohol use, whereas human papillomavirus (HPV) infection, particularly HPV16 infection, is increasingly recognized as a cause of oropharyngeal HNSCC. Despite clinical, histologic, and molecular differences between HPV-positive and HPV-negative HNSCCs, current treatment approaches are the same. For recurrent disease, these strategies include chemotherapy, immunotherapy with PD-1-inhibitors, or a monoclonal antibody, cetuximab, that targets epidermal growth factor; these therapies can be administered either as single agents or in combination. However, these treatment strategies carry a high risk of toxic side effects; therefore, more effective and less toxic treatments are needed. The landscape of HNSCC therapy is changing significantly; numerous clinical trials are underway to test novel therapeutic options like adaptive cellular therapy, antibody-drug conjugates, new targeted therapy agents, novel immunotherapy combinations, and therapeutic vaccines. This review helps in understanding the various developments in HNSCC therapy and sheds light on the path ahead in terms of further research in this field.     

基于MATLAB的传动误差测试系统及其模拟实验智能化信号发生器

介绍了机械传动误差测试中数字量计数法的特点,给出了传动误差测量系统FMT的系统框图。PC机程序采用VC调用MATLAB编译后的C函数实现FFT分析,重点介绍所研制的智能脉冲信号发生器,用其产生的两路信号对实际光栅输出信号进行模拟,进而验证FMT系统测试和FFT分析的正确性,并通过实际实验进一步验证了正确性。     

原油标准体积管结蜡造成的后果及解决方法

探讨了原油动态计量中标准体积管结蜡所引起的误差、原因分析和经济损失,提出了解决问题的办法。     

二连盆地气测解释失误层原因剖析

以往人们对气测解释评价成功的范例介绍较多,而对解释结论与试油结果不符合的层公开交流甚少。该文通过对气测解释失误层进行梳理,归纳了六条“认识不到位”等技术因素造成的解释失误和三条非技术因素造成的偏高解释,通过六个失败实例分析,总结、反思应吸取的教训,对今后的油气水层解释评价应有一定的借鉴意义。