城市库废放射源治理工作中的剂量控制

城市放射性废物库废放射源治理过程中影响工作人员受照剂量的因素较多。为实现辐射防护的最优化,本文以全国城市库治理项目统计结果及现场实施经验为依据,分析了城市库废源的特点、辐射风险及剂量控制方法。并对城市库废源治理项目的剂量数据进行统计分析,发现剂量分布规律,为辐射防护工作提供指导和参考。     

硅探测器加工中的离子注入工艺设计与控制

应用离子注入工艺可制备获得线性电流大、窗口死层薄的硅pin辐射探测器。首先简要介绍了离子注入工艺形成pn结的原理,重点根据技术要求进行了离子注入工艺设计和计算,分别得到了注入能量为40 keV和注入剂量为4×1014/cm2的两个重要控制参数。同时分析了在离子注入工艺中存在的影响因素和相应处理方法,对生产具有良好的指导作用。采用所设计的工艺参数制备获得的硅pin辐射探测器各项技术指标均满足要求,验证了离子注入工艺设计与参数控制的有效性。     

深亚微米nMOSFET器件的总剂量电离辐射效应

选取了采用0.25μm工艺的两组器件进行研究.通过对这两种器件关态泄漏电流、跨导和栅电流等电学参数进行分析,得出当器件发展到深亚微米阶段时,影响其辐射效应的主要原因是场氧化层中的陷阱电荷.并对相关机理进行了分析和仿真验证.     

CMOS/SOI 4Kb SRAM总剂量辐照实验

研究了CMOS/SOI 4Kb静态随机存储器的抗总剂量辐照性能.CMOS/SOI 4Kb静态随机存储器采用1K×4的并行结构体系,其地址取数时间为30ns,芯片尺寸为3.6mm×3.84mm;在工作电压为3V时,CMOS/SOI 4Kb静态随机存储器抗总剂量高达5×105Rad(Si),能较好地满足军用和航天领域的要求.     

Current Therapies and Technological Advances in Aqueous Aerosol Drug Delivery

Recent advances in aerosolization technology have led to renewed interest in pulmonary delivery of a variety of drugs. Pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs) have experienced success in recent years; however, many limitations are presented by formulation difficulties, inefficient delivery, and complex device designs. Simplification of the formulation process as well as adaptability of new devices has led many in the pharmaceutical industry to reconsider aerosolization in an aqueous carrier. In the acute care setting, breath-enhanced air-jet nebulizers are controlling and minimizing the amount of wasted medication, while producing a high percentage of respirable droplets. Vibrating mesh nebulizers offer advantages in higher respirable fractions (RFs) and slower velocity aerosols when compared with air-jet nebulizers. Vibrating mesh nebulizers incorporating formulation and patient adaptive components provide improvements to continuous nebulization technology by generating aerosol only when it is most likely to reach the deep lung. Novel innovations in generation of liquid aerosols are now being adapted for propellant-free pulmonary drug delivery to achieve unprecedented control over dose delivered and are leading the way for the adaptation of systemic drugs for delivery via the pulmonary route. Devices designed for the metered dose delivery of insulin, morphine, sildenafil, triptans, and various peptides are all currently under investigation for pulmonary delivery to treat nonrespiratory diseases. Although these devices are currently still in clinical testing (with the exception of the Respimat®), metered dose liquid inhalers (MDLIs) have already shown superior outcomes to current pulmonary and systemic delivery methods.     

Physicochemical stability,pharmacokinetic, and biodistribution evaluation of paclitaxel solid dispersion prepared using supercritical antisolvent process

Aim: To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process.

Methods: Physicochemical stability was performed in accelerated (40°C 70?±?5% RH) and stress (60°C) storage conditions for a period of 6 months and 4 weeks, respectively. PK and biodistribution studies were performed in rats following i.v. administration of PTX equivalent to 6 and 12?mg/kg formulations.

Results: Physical stability of PSD showed excellent stability with no recrystallization of the amorphous form. Chemical stability of PSD in terms of % PTX remaining was 98.2?±?0.6% at 6 months and 97.9?±?0.3% at 4 weeks of accelerated and stress conditions, respectively. The PK study showed a nonlinear increase in AUC with increasing dose, that is, 100% increase in dose (from 6 to 12?mg/kg) resulted in 405.90% increase in AUC. Unlike PK study, the organ distribution study of PTX from PSD showed linear relationship with dose escalation. The order of organ distribution of PTX from highest to lowest for both PSD and Taxol^® was liver>kidney>lung>brain.

Conclusions: This study demonstrated excellent physicochemical stability with insight information on the PK and biodistribution of PTX from PSD prepared by SAS process.     

A semi‐adaptive control approach to closed‐loop medication infusion

This paper presents a semi‐adaptive control approach to closed‐loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control‐oriented model for this purpose is derived via system identification and sensitivity analysis of a low‐order model capturing the direct dose‐response relationship Using the model thus derived, a model‐reference adaptive controller and a composite adaptive controller are designed and compared with each other. In‐silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points. Copyright © 2016 John Wiley & Sons, Ltd.     

油气减震支柱磨合试验台的机械原理设计

以油气减震支柱磨合试验的任务要求为输入,介绍了用减速机驱动平面四杆机构同时实现对两件产品进行磨合试验的设备的机械设计原理,该原理对其它相似产品试验台的机械设计有一定的借鉴和参考价值。     

低醇半干白葡萄酒的酵母菌耐受性研究

为了考察低醇半干白葡萄酒的酵母菌稳定性,进行山梨酸钾和游离二氧化硫不同浓度的梯度实验,以确定该产品酵母菌的安全耐受浓度.实验结果表明低醇半干白葡萄酒的山梨酸钾的适宜添加浓度为150mg/L,游离二氧化硫浓度为30mg/L～35mg/L,在此基础上酵母菌的安全耐受浓度为酵母菌数＜50个/100mL酒样.