Proliferation to Apoptosis Tumor Cell Ratio as a Biomarker to Improve Clinical Management of Pre-Malignant and Symptomatic Plasma Cell Neoplasms

Proliferation and apoptosis of neoplastic cells are prognostic biomarkers in plasma cell neoplasms (PCNs). The prognostic capacity of proliferation to apoptosis ratio (Ratio-PA) in the era of immunomodulatory treatments is re-evaluated in 316 gammopathy of undetermined significance (MGUS), 57 smoldering multiple myeloma (SMM), and 266 multiple myeloma (MM) patients. Ratio-PA of 0.77 ± 0.12, 1.94 ± 0.52, and 11.2 ± 0.7 (p < 0.0001) were observed in MGUS, SMM, and MM patients. Ten-year overall survival (10y-OS) rates for patients with low/high Ratio-PA were 93.5%/77.3% p < 0.0001) for MGUS, 82.5%/64.7% (p < 0.05) for SMM, and 62.3%/47.0% (p < 0.05) for MM. For patients with low, intermediate, and high risk, 10y-OS for low/high Ratio-PA were 95.5%/72.9% (p < 0.0001), 74.2%/50.4% (p < 0.0001), and 35.3%/20.0% (p = 0.836), respectively. Ratio-PA was an independent prognostic factor for OS (HR = 2.119, p < 0.0001, Harrell-C-statistic = 0.7440 ± 0.0194) when co-analyzed with sex, age, and standard risk. In patients with Ratio-PA^high, only first-line therapy with VRd/VTd, but not PAD/VCD, coupled with ASCT was associated with high 10y-OS (82.7%). Tumor cell Ratio-PA estimated at diagnosis offers a prognostic biomarker that complements standard risk stratification and helps to guide the clinical management of pre-malignant and symptomatic PCNs. Every effort should be made to provide first-line therapies including VTd or VRd associated with ASCT to patients with Ratio-PA^high at higher risk of progression and death.     

智能材料和智能结构——形状记忆材料

研究了形状记忆材料,如形状记忆合金、陶瓷和聚合物的结构、生产方法、特性和应用。形状记忆材料具有许多优秀的智能特性,例如传感（热、应力和场）、大行程执行器、高阻尼、自适应响应、形状记忆、超弹性等,可用于各种智能系统。形状记忆材料中的激励感应相变导致了材料的许多独特的性能,支配着材料性质的显著变化。讨论了改进目前材料系统和研发新的形状记忆材料所面临的技术障碍和挑战。     

Study of plasma-based stable and ultra-wideband electromagnetic wave absorption for stealth application

A plasma-based stable,ultra-wideband electromagnetic (EM) wave absorber structure is studied in this paper for stealth applications.The stability is maintained by a multi-layer structure with several plasma layers and dielectric layers distributed alternately.The plasma in each plasma layer is designed to be uniform,whereas it has a discrete nonuniform distribution from the overall view of the structure.The nonuniform distribution of the plasma is the key to obtaining ultra-wideband wave absorption.A discrete Epstein distribution model is put forward to constrain the nonuniform electron density of the plasma layers,by which the wave absorption range is extended to the ultra-wideband.Then,the scattering matrix method (SMM) is employed to analyze the electromagnetic reflection and absorption of the absorber structure.In the simulation,the validation of the proposed structure and model in ultra-wideband EM wave absorption is first illustrated by comparing the nonuniform plasma model with the uniform case.Then,the influence of various parameters on the EM wave reflection of the plasma are simulated and analyzed in detail,verifying the EM wave absorption performance of the absorber.The proposed structure and model are expected to be superior in some realistic applications,such as supersonic aircraft.     

FSC工作原理及其与DCS的通讯

在介绍FSC结构和通讯设置的基础上，从FSC的工作原理及其与DCS的通讯机理来详细地说明FSC控制及其与DCS通讯过程中数据管理和传输的通道。为正确理解和高水平应用FSC，确保装置事故状态下的安全提供了保证。     

二甲基硫的形成与控制

啤酒中过高的二甲基硫（DMS）含量会影响啤酒的风味。简术DMS的形成途径和影响DMS其前驱物质形成的因素,并提出控制啤酒中DMS含量的措施。     

《工业互联网安全成熟度模型:从业者指南》对我国的启示

为加速推动安全成熟度模型在工业互联网重要领域的应用落地,2019年2月25日,美国工业互联网产业联盟发布《工业互联网安全成熟度模型:从业者指南》,构建了完备的安全成熟度模型,形成了动态的工业互联网安全评估流程,并成功应用该模型开展安全实践评估工作。对此,我国应充分重视,加快开展重点领域安全评估管理实践,提速安全评测标准的研制,加快推动重点领域安全实践应用,强化安全态势感知能力建设,发挥我国产业联盟桥梁纽带作用,构建完备可靠的工业互联网安全评估体系。     

Self‐Assembly of TbPc2 Single‐Molecule Magnets on Surface through Multiple Hydrogen Bonding

The complexation between 2‐ureido‐4[1H]‐pyrimidinone (UPy) and 2,7‐diamido‐1,8‐naphthyridine (NaPy) is used to promote the mild chemisorption of a UPy‐functionalized terbium(III) double decker system on a silicon surface. The adopted strategy allows the single‐molecule magnet behavior of the system to be maintained unaltered on the surface.     

抑制闪烁噪声的SMM-IUKF目标跟踪算法

针对末制导被动雷达跟踪测量的闪烁噪声问题,在分析多模型滤波及其简化算法的基础上,采用迭代不敏卡尔曼滤波(IUKF),设计了一种简化的多模型滤波器(SMM-IUKF),并以一个典型三维目标跟踪问题为例进行了蒙特卡洛仿真验证.该算法具有与SMM算法同阶的计算量,估计精确度高、收敛速度快,较好地解决了闪烁噪声滤波问题.     

控制系统通信技术的应用

介绍海洋石油二期项目的DCS、PLC系统,以DCS为核心,各PLC作为子系统,DCS通过EPLCG、SI通信卡、SMM通信模块与PLC之间通信的原理及应用,通讯技术的应用给事故分析带来的益处.     

Analysis of the flow pattern and periodicity of gas–liquid–liquid three-phase flow in a countercurrent mixer-settler

In contrast to the concurrent mixer-settler, the interaction between the mixing and settling chambers have to be taken into account in the simulation of the countercurrent mixer-settler, and no work has been reported for this equipment. In this work, a three-phase flow model based on the Eulerian multiphase model, coupled with a sliding mesh model is proposed for a countercurrent mixer-settler. Based on this, the dispersed phase distribution, flow pattern, and pressure distribution are investigated, which can help to fill the gap in the operation mechanism. In addition, the velocity vector distribution at the phase port shows an intriguing phenomenon that two types of vectors with opposite directions are distributed on the left and right sides of the same plane, which indicates that the material exchange in the mixing and settling chambers is simultaneous. Analysis of this variation at this location by a fast Fourier transform (FFT) method reveals that it is mainly influenced by the mixing chamber and is consistent with the main period of the outlet flow fluctuations. Therefore, by monitoring the fluctuation of the outlet flow and then analyzing it by the FFT method, the state of the whole tank can be determined, which makes it promising for the design of control systems for countercurrent mixer-settlers.