Mechanical procedure for proof construction via closed terms in typed λ calculus

In this paper is presented an algorithm for constructing natural deduction proofs in the propositional intuitionistic and classical logics according to the analogy relating intuitionistic propositional formulas and natural deduction proofs, respectively, to types and terms of simple type theory. Proofs are constructed as closed terms in the simple typed calculus. The soundness and completeness of this method are proved.     

Sex pheromones of male yellowfin Baikal sculpin (Cottocomephorus grewingki): Isolation and chemical studies

Three components of the male yellowfin Baikal sculpin pheromonal signal have been isolated from urine by diethyl ether extraction, thinayer chromatography (TLC), and high-performance liquid chromatography (HPLC). Using mass spectrometry, we have identified two of them as testosterone (T) and 11-hydroxytestosterone (11HT). These steroids are synthesized in testes during full spermatogenesis, and they are excreted in male urine with milt. The third component is not a steroid. It is more likely to be a polyene alcohol (farnesol). 2Z,6E-Farnesol possesses behavioral activity.     

基于OWASP的WEB应用安全检测与防范

Web应用发展迅速,但多数开发人员安全意识差,导致Web应用漏洞百出。针对web开发时的安全风险,提出了基于OWASP的统计和文档的WEB应用安全检查和防范的方法,来降低Web应用的安全风险,并通过银行项目中的实际应用,表明该方法不但能提高Web应用安全性,同时增强了开发人员的安全意识。     

Aluminum. II. Derivation of C v0from C p and comparison to C v0 calculated from anharmonic models

The specific heat at constant pressure, C _p, of aluminum measured by Ditmars, Plint, and Shukla has been reduced to the volume V ₀ appropriate for 0 K employing the Murnaghan equation. The C _v0 thus obtained is compared with the theoretical C _v0 calculated in the harmonic and the lowest-order anharmonic approximation from three different pseudopotentials (Harrison, Ashcroft, and Dagens-Rasolt-Taylor) as well as a phenomenological Morse potential. The higher-order ( ⁴) anharmonic contributions are calculated from the same nearest-neighbor Morse potential as in the lowest-order anharmonic theory. The role of the vacancy and the higher-order anharmonic contributions to C _v0 has been examined and we conclude that the ⁴ contributions to C _v0 are much smaller than the vacancy contribution. After removal of the vacancy contribution, the reduced C _v0 is found to be in excellent agreement with the Ashcroft and Harrison pseudopotentials as well as the Morse potential including the ² and ⁴ contributions to C _v0.     

Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells

Hormone-specific anticancer drugs for breast cancer treatment can cause serious side effects. Thus, treatment with natural compounds has been considered a better approach as this minimizes side effects and has multiple targets. 6-Gingerol is an active polyphenol in ginger with various modalities, including anticancer activity, although its mechanism of action remains unknown. Increases in the level of reactive oxygen species (ROS) can lead to DNA damage and the induction of DNA damage response (DDR) mechanism, leading to cell cycle arrest apoptosis and tumorsphere suppression. Epidermal growth factor receptor (EGFR) promotes tumor growth by stimulating signaling of downstream targets that in turn activates tumor protein 53 (p53) to promote apoptosis. Here we assessed the effect of 6-gingerol treatment on MDA-MB-231 and MCF-7 breast cancer cell lines. 6-Gingerol induced cellular and mitochondrial ROS that elevated DDR through ataxia-telangiectasia mutated and p53 activation. 6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c. It also exhibited a suppression ability of tumorsphere formation in breast cancer cells. EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells. Therefore, 6-gingerol may be used as a candidate drug against hormone-dependent breast cancer cells.     

TEM and DFT investigation of CVD TiN/κ-Al2O3 multilayer coatings

This paper investigates the interfacial structure in hot-wall CVD TiN/κ-Al₂O₃ multilayer coatings using both HREM and DFT modeling. Two multilayers with different thicknesses of the TiN layers (50 and 600 nm) separating the κ-Al₂O₃ layers are analyzed. The general microstructure of the two multilayers is relatively similar. The TiN layer in the thicker TiN/κ-Al₂O₃ coating is thick enough to be several TiN grains high. This means that epitaxial columns, which are often found in the thinner TiN/κ-Al₂O₃ coatings, are not present. However, the orientation relationships at the TiN/κ-Al₂O₃ interfaces are the same in both multilayers. The HREM investigations show that κ-Al₂O₃ (001) planes can grow directly on flat (111) TiN faces, without any other phases or detectable amounts of impurities, such as sulphur, present. Where the TiN layers are more curved, γ-Al₂O₃ can be grown, at least partly stabilized by the cube-on-cube orientation relationship between γ-Al₂O₃ and the underlying TiN. The DFT calculations show very similar adsorption strengths for an O monolayer positioned on Ti-terminated TiC(111) and TiN(111) surfaces, with preferred adsorption in the fcc site. O adsorption on N-terminated TiN(111) is much weaker, with preferred adsorption in the top site. Calculated elastic-energy contributions yield a higher stability for κ-Al₂O₃ on TiN(111) than on TiC(111) and a higher stability for κ-Al₂O₃ than for α-Al₂O₃ on both TiC and TiN. This indicates that the observed higher stability of κ-Al₂O₃ on TiC(111) than on TiN(111) is not due to the lattice mismatch, while the preferred epitaxial growth of κ-Al₂O₃ over α-Al₂O₃ can be partly attributed to the mismatch.     

00Crl8Nil0N奥氏体不锈钢200 - 600℃高温疲劳性能的研究

试验用00Cr18Ni10N钢（/%:0.018C,0.41Si,1.68Mn,18.18Cr,10.38Ni,0.16N）经1t EAF-AOD-ESR冶炼,锻成Φ30 mm材和1 050℃固溶处理,进行了00Cr18Ni10N钢200～600℃光滑（K_t=1）、缺口（K_t=3）的轴向高周疲劳性能研究,绘制了疲劳S-N曲线、计算了疲劳极限,并对疲劳试样的典型断口进行了SEM观察。结果表明,光滑试样的疲劳极限随试验温度升高而降低,缺口试样的疲劳极限对试验温度变化不敏感。当应力集中系数由K_t=1提高到K_t=3时,00Cr18Ni10N钢的200、400、600℃下10⁷周次条件疲劳极限分别从530、506、410 MPa,降低到323、370、392 MPa。表明在高温下00Cr18Ni10N钢存在疲劳极限对应力集中敏感,且应力集中敏感性随着试验温度的升高而降低。疲劳试样的断口形貌由疲劳源区、疲劳裂纹扩展区和瞬断区组成,疲劳起源于表面加工刀痕的不连续位置,呈韧性断裂特征。     

反应堆A0纯铝的点蚀模拟

测量A0纯铝在去离子水中的极化曲线用来模拟反应堆池壳的点蚀.研究表明A0纯铝在去离子水中很容易钝化.实验中用美国EG&G普林斯顿应用研究公司生产的273型恒电位/恒电流仪测量模拟孔电位,极化曲线表明模拟腐蚀坑处于钝化状态,即便是氧化膜破裂,腐蚀坑也发展得很慢.用pH计测量孔中pH的变化,并得到其工作曲线,此曲线表明带有氧化膜的点蚀坑坑内存在明显的酸化现象.并对A0铝池壳的服务寿命进行了估计.     

锡磷青铜合金水平连铸工艺参数的优化

铸造锡磷青铜合金组织中存在显微缩松、枝晶偏析和反偏析是冷加工报废的主要原因.通过连铸工艺参数的正交实验,建立了轧制成材率与主要工艺参数之间的神经网络描述,网络模型与遗传算法结合对工艺参数的组合进行了优化,改善了铸坯的组织,提高了轧制带材成材率.