人群头发元素分布及某些特征研究

本文介绍用堆中子活化分析法测定人群头发中I、Br、Mg、Mn、Cu、Na、V、Cl、Al、Ca、S等11种元素。研究人发中元素分布特征、相关性特征、性别年令分布特征。方法学中还从法庭科学应用角度介绍同一性识别中差异率和重合几率的双判据方法。     

The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia mainly due to pancreatic β cell death and/or dysfunction, caused by several types of stress such as glucotoxicity, lipotoxicity and inflammation. Different patho-physiological mechanisms driving β cell response to these stresses are tightly regulated by microRNAs (miRNAs), a class of negative regulators of gene expression, involved in pathogenic mechanisms occurring in diabetes and in its complications. In this review, we aim to shed light on the most important miRNAs regulating the maintenance and the robustness of β cell identity, as well as on those miRNAs involved in the pathogenesis of the two main forms of diabetes mellitus, i.e., type 1 and type 2 diabetes. Additionally, we acknowledge that the understanding of miRNAs-regulated molecular mechanisms is fundamental in order to develop specific and effective strategies based on miRNAs as therapeutic targets, employing innovative molecules.     

Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors

The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms governing these processes is, thus, extremely valuable for managing the disease progression. Extracellular glucose is known to influence cell identity by impacting the redox balance. Here, we use global proteomics and pathway analysis to map the response of differentiating human pancreatic progenitors to chronically increased in vitro glucose levels. We show that exogenous high glucose levels impact different protein subsets in a concentration-dependent manner. In contrast, regardless of concentration, glucose elicits an antipodal effect on the proteome landscape, inducing both beneficial and detrimental changes in regard to achieving the desired islet cell fingerprint. Furthermore, we identified that only a subgroup of these effects and pathways are regulated by changes in redox balance. Our study highlights a complex effect of exogenous glucose on differentiating pancreas progenitors characterized by a distinct proteome signature.     

基于MMS替代协议的变电站安全通信技术研究及应用

目前,绝大多数变电站基于IEC61850标准建设,站内通信协议主要包括制造报文规范(MMS)、面向通用对象的变电站事件(GOOSE)、采样测量值(SMV)等,在工程应用实践中逐渐暴露出一些不足与安全隐患.为此,基于MMS替代协议,重点介绍了其实现的功能与安全防护技术.在功能方面,MMS替代协议增加了多个服务,并优化了现有MMS协议的不足;在安全防护技术方面,MMS替代协议的应用层实现了基于SM2算法与调度证书的双向身份认证,杜绝未授权设备的非法接入、攻击,从协议源头杜绝设备连接的不安全性;MMS替代协议的传输层实现了基于SM2算法与调度证书的全链路加密、认证,确保传输数据报文防伪造、防抵赖、防窃取,保护数据报文的机密性、完整性.测试结果表明MMS替代协议在工程应用中具有一定的参考意义.     

PXI总线幅相一致性测试模块设计

幅相一致性是单脉冲体制相控阵雷达的重要指标,其对雷达测角精度影响很大。采用虚拟仪器技术、自适应处理技术设计了基于PXI总线的幅相一致性测试模块,实现了幅相一致性的快速同步自动测试。试验结果表明,该模块在测试精度、测试方便性和实用性方面与专业矢量电压表测试结果相当。对雷达性能测试能力的提高具有很大的实用价值和指导意义。     

车联网中基于雾计算和多TA的条件隐私保护认证方案

车联网在生活中扮演着越来越重要的角色,它可以有效地防止交通拥堵从而减少交通事故。然而,在车联网中总是有非法车辆试图接入车联网并发布虚假消息。此外,现有方案多数存在计算效率低下的问题。针对上述存在的问题进行了研究,提出了一种车联网中基于雾计算和多TA的条件隐私保护认证方案。在保护车辆用户身份的条件下实现了车辆、雾节点、TA三者之间的身份认证,且在车辆追踪阶段可以还原车辆用户的真实身份,从而实现条件隐私保护。雾计算的使用降低了方案的计算和通信开销,同时多TA模型的使用也解决了单TA单点故障的问题。安全性证明和性能分析的结果表明该方案是安全且高效的。最后对当前方案进行了总结以及对未来研究作出了展望。     

Investigating Modern‐Day Talaria: Mobile Phones and the Mobility‐Impaired in Singapore

Revisiting the medical and social models of disability, this study adopted the integrated biopsychosocial approach to examine experiences of 25 mobility‐impaired respondents in Singapore with using mobile phones. We found that mobile phones provided respondents a greater degree of mobility, a sense of control, and opportunities to escape the stigma of disability, thus challenging the boundaries between the able‐bodied and the disabled. Mobile phone appropriation allowed the management of personal identities and social networks, leading to a sense of empowerment. However, mobile phone usage might act as a double‐edged sword for disabled people, creating mobile dependencies and a spatial narrowing of social connections. Theoretical and practical implications are discussed.     

公式分层的谓词模态逻辑

由于必然模态词□的引入,谓词模态逻辑的公式在一个可能世界中的真假值可能依赖于其可达的可能世界.在谓词模态逻辑中存在个体跨可能世界相等问题.针对这一问题,Lewis提出了对应物理论,并且在对应物理论中用对应物关系来表示个体跨可能世界相等.但是,当一个对象具有一个以上的对应物时,谓词模态逻辑中的跨可能世界相等关系无法与对应物关系建立一一对应.通过限制谓词模态逻辑中全称量词∀的范围,给出了一种公式分层的谓词模态逻辑.它是谓词模态逻辑的一个子逻辑,并且其语言与谓词模态逻辑的语言是相同的.但其公式是分层定义的,使得∀可以出现在□的范围内,并且□不能出现在∀的范围内.由于任意形如∀x□φ（x）的表达式都不是该逻辑的公式,以量词开头的公式在一个可能世界w中的真假值只依赖于w,该逻辑避免了个体跨可能世界相等问题.给出了该逻辑的语言、语法和语义,并证明了该逻辑是可靠的和完备的.     

基于生物加密的认证机制

为克服传统认证技术在保护安全和隐私方面的不足,提出了一种基于生物加密的身份认证模型。运用生物加密技术对用户脸部特征和密钥进行保护,防止非授权用户的访问和非授权资源的使用。实验结果表明,尽管人的面部表情变化多端,基于生物加密技术的认证系统仍能正确区分真正的用户与仿冒用户,起到很好的认证效果,保证了安全通信。     

虚拟实验平台信息安全架构设计

依托＂十一五＂国家科技支撑计划重点项目《虚拟实验教学环境关键技术研究与应用示范》,构建一个开放、共享、高安全性的虚拟实验共享平台,使用户对实验的使用从传统的分散小群体模式提升到按需使用跨区域第三方运营的共享模式。本文提出了基于USB Key的CA认证体系,设计了虚拟实验网络的安全结构和试验平台的身份认证系统。用户通过USB Key认证登录后,即可使用本域内或远程的并行计算环境,按照系统提供的标准服务规范,与实验系统远程交互。