磨机负荷检测系统无线数据采集装置的研制

针对球磨机振动信号采集及数据传输,研制了一套低功耗无线采集传输系统。通过对电路系统的降噪设计,提高了处理精度,使其完全满足数据采集的需要,解决了在线检测球磨机桶壁振动装置的连续使用问题。     

The effect of triangular shutter type flow deflector perforated baffle plate on the thermofluid performance of a heat exchanger

The study aimed to investigate the heat transfer (HT) properties of a tubular heat exchanger (HX) by using innovative baffle plate arrangements. The newly designed baffle plate was circular with triangular openings and adjustable triangular flow deflectors. These deflectors were strategically placed at the inlet of the HX to create a swirling flow downstream. Three baffle plates were installed along the flow direction with different length-to-diameter ratios (pitch ratios) to assess their impact on HT, pressure drop, and thermal enhancement factor. The study compared these results with a smooth channel under varying Reynolds numbers (16,500–29,500). The findings revealed that both the pitch ratio (0.6–1.2) and the inclination angle of the deflectors (30⁰–50⁰) significantly affected the HX's performance. Notably, the baffle plate with a deflector inclination angle of 30° and a pitch ratio of 1 showed a remarkable average improvement of 36.5% compared to other angles and ratios.     

排式双翼布局低雷诺数气动特性计算研究

作为一种新型的气动布局形式,排式布局对低雷诺数流动具有较高的气动效率,适用于柔性可充气飞行器,比如充气式飞机或是高空飞艇。但是,由于前、后翼之间强烈的气动干扰现象,目前对此类布局的气动特性认识还十分有限。为了充分理解这种布局的气动特点,在前期风洞试验的基础上,开展了数值模拟工作,详细地研究了低雷诺数情况下翼型厚度、表面波纹状外形及后翼偏转角度等几何因素对此类飞行器气动特性的影响规律。计算结果表明,在计算的迎角范围内,排式布局能通过前后翼之间的气动干扰延缓或抑制机翼后缘处的流动分离,从而提高整体气动效率,因此排式布局在未来很适合应用于小型无人机或是飞艇等可充气式飞行器构型上。     

基于热流场仿真的井状通路暖气垫的结构优化

路面结冰易于导致交通事故的发生,因此提出一种路面暖气垫融冰法。为了获得最佳的融冰效果,以固定体积暖气垫为研究对象,将暖气垫工作表面的融冰速率和融冰均匀度作为评估指标,以暖气垫长度、厚度和通路间距为优化参数,通过热流场仿真分析,采用均匀设计响应面法得到优化目标与结构参数间的函数关系,运用遗传算法进行多目标优化得到非劣解集,采用理想点法TOPSIS从中选出最优解,得出结论:当通路直径取20 mm时,最佳参数组合为通路间距48 mm、暖气垫厚度68 mm,横向边长可根据工程应用确定。     

Quantifying the Detrimental Effects of Multiple Freeze/Thaw Cycles on Primary Human Lymphocyte Survival and Function

The use of cryopreserved peripheral blood mononuclear cells is common in biological research. It is widely accepted that primary cells are rendered unusable by several freezing cycles, although this practice might be very helpful when the biological material is valuable and its re-collection is impractical. To determine the extent to which primary cells undergoing repeated freezing cycles are comparable to one another and to fresh samples, we evaluated overall lymphocyte viability, their proliferation and cytokine production capabilities, as well as the levels of 27 cell subtypes in ten human peripheral blood mononuclear cells frozen for five years and repeatedly thawed. As expected, we observed a progressive increase in cell death percentages on three rounds of thawing, but the frequency of the main lymphocyte subsets was stable across the three thawings. Nevertheless, we observed a significant reduction of B cell frequency in frozen samples compared to fresh ones. On repeated thawings and subsequent conventional stimulation, lymphocyte proliferation significantly decreased, and IL-10, IL-6, GM-CSF, IFN-gamma, and IL-8 showed a trend to lower values.     

GSK3β Inhibition by Phosphorylation at Ser389 Controls Neuroinflammation

The inhibition of Glycogen Synthase Kinase 3 β (GSK3β) by Ser⁹ phosphorylation affects many physiological processes, including the immune response. However, the consequences of GSK3β inhibition by alternative Ser³⁸⁹ phosphorylation remain poorly characterized. Here we have examined neuroinflammation in GSK3β Ser³⁸⁹ knock-in (KI) mice, in which the phosphorylation of Ser³⁸⁹ GSK3β is impaired. The number of activated microglia/infiltrated macrophages, astrocytes, and infiltrated neutrophils was significantly higher in these animals compared to C57BL/6J wild-type (WT) counterparts, which suggests that the failure to inactivate GSK3β by Ser³⁸⁹ phosphorylation results in sustained low-grade neuroinflammation. Moreover, glial cell activation and brain infiltration of immune cells in response to lipopolysaccharide (LPS) failed in GSK3β Ser³⁸⁹ KI mice. Such effects were brain-specific, as peripheral immunity was not similarly affected. Additionally, phosphorylation of the IkB kinase complex (IKK) in response to LPS failed in GSK3β Ser³⁸⁹ KI mice, while STAT3 phosphorylation was fully conserved, suggesting that the NF-κB signaling pathway is specifically affected by this GSK3β regulatory pathway. Overall, our findings indicate that GSK3β inactivation by Ser³⁸⁹ phosphorylation controls the brain inflammatory response, raising the need to evaluate its role in the progression of neuroinflammatory pathologies.     

基于隐函数模型的光学微腔传输光谱拟合算法

光学微腔品质因子高、灵敏度高,在精密生物传感方面有广阔的应用前景。针对洛伦兹拟合算法不能很好地拟合光学微腔输出端非对称波形和劈裂模式波形的问题,提出了隐函数模型算法。该算法首先建立模板波形,然后经平移、放缩理论实现模板波形操作,利用Levenberg-Marquardt (LM)算法优化参数值,能够实现对称波形、非对称波形和劈裂模式波形数据拟合。通过搭建光学微腔数据采集系统,采用高斯、洛伦兹和隐函数模型算法对不同折射率溶液的实验数据进行拟合。结果表明：隐函数模型算法比前两种算法的MSE低1个数量级,且拟合优度(R2)达到了0.99,拟合效果较好;隐函数模型算法谐振频率误差最小,谐振频率偏移量最大,对应的灵敏度最高,有利于提高光学微腔灵敏度。     

基于多网融合及联动的煤矿安全监控系统设计

分析了目前煤矿安全监控系统的结构和应用中存在的主要问题,提出了监控系统全数字化传输的解决方案。在全数字化传输系统中对监控分站的功能,以及断电器、多系统融合的工作流程进行了重新定义,使多网融合和系统间的联动在煤矿安全监控系统中的实现变得简单易行,可为煤矿实现信息共享及协同处理提供新的解决思路。     

细长铜管内壁化学流镀镍-磷合金工艺的研究

介绍了细长铜管内壁化学流镀镍-磷合金工艺。探讨了铜及其合金化学镀镍触发时间的影响因素。研究了铜管内壁溶液流速与沉积速率的关系。     

缝洞型油藏剩余油分布预测及挖潜技术对策

塔河油田缝洞型油藏非均质性强,油井开发递减较快,油藏采收率较低.在缝洞型油藏地质特征和开发特征分析的基础上,提出在缝洞单元内部划分单井流动单元的概念,同时结合油藏开发方式,在地质认识上对剩余油富集区进行预测.物性相对较差能量相对较弱局部充填封隔部位,水淹部位侧翼和局部构造高位置,注水开发后油藏中低效替油部位,水驱死角区域以及各个单井流动单元之间连通程度较差部位是剩余油富集区.这些剩余油的开采,对于供液能力和能量下降油井,注水采油和可控性大型压裂仍是有效手段;针对水淹井或者初期注水失效井,实施排水采油或者水力扩容技术;注入N₂或CO₂是进行三次采油的经济且有效手段;部署侧钻和加密井可精确挖潜剩余油.