Nonalcoholic Fatty Liver: A Possible New Target for Type 2 Diabetes Prevention and Treatment

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Several lines of evidence have indicated a pathogenic role of insulin resistance, and a strong association with type 2 diabetes (T2MD) and metabolic syndrome. Importantly, NAFLD appears to enhance the risk for T2MD, as well as worsen glycemic control and cardiovascular disease in diabetic patients. In turn, T2MD may promote NAFLD progression. The opportunity to take into account NAFLD in T2MD prevention and care has stimulated several clinical studies in which antidiabetic drugs, such as metformin, thiazolidinediones, GLP-1 analogues and DPP-4 inhibitors have been evaluated in NAFLD patients. In this review, we provide an overview of preclinical and clinical evidences on the possible efficacy of antidiabetic drugs in NAFLD treatment. Overall, available data suggest that metformin has beneficial effects on body weight reduction and metabolic parameters, with uncertain effects on liver histology, while pioglitazone may improve liver histology. Few data, mostly preclinical, are available on DPP4 inhibitors and GLP-1 analogues. The heterogeneity of these studies and the small number of patients do not allow for firm conclusions about treatment guidelines, and further randomized, controlled studies are needed.     

Non-Coding RNAs in Muscle Dystrophies

ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches. Important data come from the field of hereditary muscle dystrophies, like Duchenne muscle dystrophy and Myotonic dystrophies, rare diseases affecting 1 in 7000–15,000 newborns and is characterized by severe to mild muscle weakness associated with cardiac involvement. Novel therapeutic approaches are now ongoing for these diseases, also based on splicing modulation. In this review we provide an overview about ncRNAs and their behavior in muscular dystrophy and explore their links with diagnosis, prognosis and treatments, highlighting the role of regulatory RNAs in these pathologies.     

在DM642EVM平台上实现H.263视频编解码

本文详细介绍了在DM642EVM平台上实现H．263标准的实时编解码的过程，根据自己提出的测试方法得到峰值信噪比．时延等数据，证明我们的编解码软件达到了很高的效率，最后总结了在进行DSP系统开发的过程中得到的优化经验．并提出改进效率的方案。     

基于多深度概念树与遗传算法的数据挖掘技术研究

在改进传统意义上的概念树的基础上，提出构建多深度概念树的思想。并发挥遗传算法的优势，进行多深度数据挖掘，可以同时得到针对某一类产品销售与进货的规则。这在非自选式（非超市型）商品（需专家经验）的销售行业有着良好的应用前景。     

基于数据仓库的经济监测与管理决策支持系统

数据仓库技术是在充分地开发信息资源的迫切要求下产生并迅速发展起来的一个国际前沿研究新领域。介绍了数据仓库、数据挖掘、联机分析处理技术,同时给出了基于数据仓库的经济监测与管理决策支持系统的体系结构与实现方法。     

基于AVS—M和DM642视频服务器的研究

本文完成了视频服务器的硬件设计，针对如何充分发挥DM642硬件平台的处理能力，提出了关于AVS-M算法的编码优化方案．该方案是对软件框架流程进行仔细考虑后提出的，避免了冗余操作，针对存储系统对各部分的数据结构进行了设计．而且通过DMA实现了计算与数据传输的并行处理。     

计算机集成制造系统的概念、发展及结构改进

阐述了管理信息系统MIS(ManagementInformationSystem)计算机集成制造系统CIMS(ComputerIntegratedManufactureSystem)概念、内涵 ,结合数据挖掘DM(DataMining)提出了未来CIMS发展的可能结构     

证券公司数据仓库解决方案

介绍了数据仓库、联机分析处理和数据挖掘技术。在对我国证券公司应用需求和信息系统现状进行了详细分析的基础上，提出了证券公司数据仓库的整体构架，并对其逻辑设计、数据抽取与转换、前端展现程序设计方案进行了探讨。     

基于TMS320DM642的图像采集和处理系统的研究

本文介绍一种基于定点DSP芯片TMS320DM642的视频图像采集和处理系统，其主要功能是从CCD摄像头输出的模拟视频信号中提取实时图像，数字化后送入处理器作后继图像处理和分析。本系统具有良好的通用性和可扩展性，可以被应用于视频图像采集和处理的各种场合中。本文给出了该系统较完整的硬件和软件设计方案。